The effect of solifenacin on postvoid dribbling in women: results of a randomized, double-blind placebo-controlled trial

Ablove, Tova; Bell, Lauren N.; Liang, Hong; Chappell, Richard J.; Toklu, Hale Z.; Yale, Steven H.

doi:10.1007/s00192-018-3594-6

Cited by 3 publications

(3 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Antibiotics, the most common therapy used in clinical practice, may help symptomatic remission, but the efficacy is not durable. Alpha blockers or anticholinergics are effective for treating LUTS associated with benign prostatic hyperplasia, but they cannot play a similar role in treating women with LUTS . New treatments are being explored.…”

Section: Discussionmentioning

confidence: 99%

Transurethral resection in women with symptomatic keratinizing squamous metaplasia of urinary bladder: A retrospective study of 92 cases

Wang

Chong

Tang

et al. 2019

LUTS

View full text Add to dashboard Cite

Objectives: To investigate the efficacy of transurethral resection (TUR) on relieving urinary symptoms in patients with keratinizing squamous metaplasia (KSM) of the urinary bladder.Methods: Data were analyzed from a retrospective study of patients receiving transurethral bipolar plasma resection (bi-TUR) treatment for symptomatic KSM. Urinary symptoms were assessed by the International Prostate Symptom Score (IPSS) and a numeric rating scale pain score. Efficacy was assessed using the IPSS to determine changes from baseline in lower urinary tract symptoms (LUTS). Self-reported quality of life (QoL) was assessed by the last question of the IPSS questionnaire.Results: A total of 92 female patients were included in the analysis. The median age was 42 years. LUTS, pain, and hematuria were the most common symptoms that affected patients. The median follow-up duration was 51 months. There were significant improvements in LUTS from baseline IPSS after TUR (P < .001). The percentage of the patients with moderate to severe LUTS went down from 52.2% to 18.5%. The median Numeric Rating Scale (NRS)-11 pain score reduced from 3 at baseline to 0 at the last visit. Twentyone out of 40 patients reported that the pain symptoms disappeared completely. No patients reported hematuria symptoms at the final follow-up. Improvement of selfreported QoL was significant (P < .001). A total of 57.6% of patients reported an improvement, 26.1% of patients reported no improvement, and 16.3% reported deterioration.Conclusions: Bi-TUR therapy significantly relieved urinary symptoms in women with KSM. Improvement of QoL was acceptable with a success rate of 57.6%. Considering the very low complication rate, our study supported bi-TUR as an alternative treatment for patients who are resistant to medical therapy. K E Y W O R D S female, LUTS, squamous metaplasia, transurethral resection

show abstract

Section: Discussionmentioning

confidence: 99%

Transurethral resection in women with symptomatic keratinizing squamous metaplasia of urinary bladder: A retrospective study of 92 cases

Wang

Chong

Tang

et al. 2019

LUTS

View full text Add to dashboard Cite

show abstract

“…One trial found that, for patients with UUI plus more severe/common postvoid dribbling, anticholinergics resulted in greater reduction of postvoid dribbling episodes compared with placebo. 6 In Ablove's postmenopausal patients, postvoid dribbling also showed an association with age, body mass index, and the length of the genital hiatus. 5 Although some have speculated that postvoid dribbling may result from pelvic floor weakness, indicating a presumed increase with age, 2 Ablove 5 actually suggested a decreased incidence of postvoid dribble with increasing age.…”

Section: Discussionmentioning

confidence: 98%

“…Similar to our study's findings, in Ablove's premenopausal and perimenopausal patients, postvoid dribbling was associated with UUI. One trial found that, for patients with UUI plus more severe/common postvoid dribbling, anticholinergics resulted in greater reduction of postvoid dribbling episodes compared with placebo 6 . In Ablove's postmenopausal patients, postvoid dribbling also showed an association with age, body mass index, and the length of the genital hiatus 5 .…”

Section: Discussionmentioning

confidence: 99%

Prevalence and Bother of Postvoid Dribbling and Urine Spraying or Splitting: Survey of a General Gynecology Population

Hicks¹,

Hare²,

Pruszynski³

et al. 2022

UROGC

View full text Add to dashboard Cite

Importance Postvoid dribbling is described well for men in urologic literature but is poorly defined for women, especially in those not presenting for urogynecologic care. Objective The objective was to assess prevalence and bother of postvoid dribbling, urine spraying (ie, deviation of the urine stream), and other bothersome voiding/storage symptoms in a general gynecology population. Study Design This was an anonymous cross-sectional survey study of women presenting to academic general gynecology practices for benign gynecologic care or well-woman visits; patients were not presenting for urinary incontinence or voiding dysfunction. A questionnaire was used to assess the presence and perceptions of voiding behavior and urinary symptoms with an emphasis on postvoid dribbling and urine spraying. The questionnaire included both the validated Questionnaire for Urinary Incontinence Diagnosis and nonvalidated questions. Results Nonpregnant adult women (N = 355) were surveyed. The median age was 43 years (interquartile range, 33-51 years). The sample was 45% White, 23% Black, 3% Asian, and 13% other. Furthermore, 39% were Latina; 68%, parous; and 28%, postmenopausal. The prevalence (95% confidence interval) of immediate postvoid dribbling was 186 of 327 or 57% (51-62%), and of these, it was at least somewhat bothersome in 37% but moderately-toquite-a-bit bothersome in 8%. Urine spraying occurred in 222 of 333 or 67% (61-72%), and of these, it was at least somewhat bothersome in 53% but moderately-to-quite-a-bit bothersome in 17%. Approximately 20% reported stress and/or urgency urinary incontinence; both postvoid dribbling and urine spraying were highly associated with these symptoms. Conclusions This study of women seeking benign gynecologic care shows a high prevalence of postvoid dribbling and urine spraying symptoms. However, moderate-or-greater bother was relatively uncommon.

show abstract

Oral anticholinergic drugs versus placebo or no treatment for managing overactive bladder syndrome in adults

Stoniute

Madhuvrata

Still

et al. 2023

Cochrane Database of Systematic Reviews

View full text Add to dashboard Cite

BackgroundAround 16% of adults have symptoms of overactive bladder (OAB; urgency with frequency and/or urge incontinence), with prevalence increasing with age. Anticholinergic drugs are commonly used to treat this condition. This is an update of a Cochrane Review first published in 2002 and last updated in 2006. ObjectivesTo assess the e ects of anticholinergic drugs compared with placebo or no treatment for treating overactive bladder syndrome in adults. Search methodsWe searched the Cochrane Incontinence Specialised Register, which contains trials identified from the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE, MEDLINE In-Process, MEDLINE Epub Ahead of Print, ClinicalTrials.gov, WHO ICTRP and handsearching of journals and conference proceedings (searched 14 January 2020), and the reference lists of relevant articles. We updated this search on 3 May 2022, but these results have not yet been fully incorporated. Selection criteriaWe included randomised or quasi-randomised trials in adults with overactive bladder syndrome that compared an anticholinergic drug alone with placebo treatment. Data collection and analysisTwo review authors independently assessed eligibility and extracted data from the included studies, including an assessment of the risk of bias. We assessed the certainty of the body of evidence using the GRADE approach. We processed data as described in the Cochrane Handbook for Systematic Reviews of Interventions. Main resultsWe included 104 studies, 71 of which were new or updated for this version of the review. Although 12 studies did not report the number of participants, there were 47,106 people in the remainder of the included studies. The majority of the studies had insu icient information to Oral anticholinergic drugs versus placebo or no treatment for managing overactive bladder syndrome in adults (Review)

show abstract

The effect of solifenacin on postvoid dribbling in women: results of a randomized, double-blind placebo-controlled trial

Abstract: There were no differences in PVD outcomes between the solifenacin and placebo groups. Solifenacin may play a role in treating women with the most severe symptoms. Because of the powerful placebo response seen in this study, behavior-based interventions may be useful for treating PVD.

Cited by 3 publications

References 27 publications

Transurethral resection in women with symptomatic keratinizing squamous metaplasia of urinary bladder: A retrospective study of 92 cases

Transurethral resection in women with symptomatic keratinizing squamous metaplasia of urinary bladder: A retrospective study of 92 cases

Prevalence and Bother of Postvoid Dribbling and Urine Spraying or Splitting: Survey of a General Gynecology Population

Oral anticholinergic drugs versus placebo or no treatment for managing overactive bladder syndrome in adults

Contact Info

Product

Resources

About