The Effect of Solvation on Electron Attachment to Pure and Hydrated Pyrimidine Clusters

Neustetter, Michael; Aysina, Julia; Silva, F. Ferreira da; Denifl, Stephan

doi:10.1002/anie.201503733

Cited by 53 publications

(47 citation statements)

References 28 publications

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“…The behavior of fragmentation induced by energetic particles may change substantially from isolated molecules to molecular clusters that represent the condensed phase [16][17][18]. The excess energy deposited by the projectile in the presence of other molecules or a solvent may be transferred to the surrounding species and lead to buffering effects in dissociation.…”

Section: Introductionmentioning

confidence: 99%

Ion formation upon electron collisions with valine embedded in helium nanodroplets

et al. 2016

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Abstract. We report here experimental results for the electron ionization of large superfluid helium nanodroplets with sizes of about 10 5 atoms that are doped with valine and clusters of valine. Spectra of both cations and anions were monitored with high-resolution time-of-flight mass spectrometry (mass resolution >4000). Clear series of peaks with valine cluster sizes up to at least 40 and spaced by the mass of a valine molecule are visible in both the cation and anion spectra. Ion efficiency curves are presented for selected cations and anions at electron energies up to about 40 eV and these provide insight into the mode of ion formation. The measured onset of 24.59 eV for cations is indicative of valine ionization by He + whereas broad resonances at 2, 10 and 22 eV (and beyond) in the formation of anions speak to the occurrence of various modes of dissociative electron attachment by collisions with electrons or He* − and the influence of droplet size on the relative importance of these processes. Comparisons are also made with gas phase results and these provide insight into a matrix effect within the superfluid helium nanodroplet.

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Section: Introductionmentioning

confidence: 99%

Ion formation upon electron collisions with valine embedded in helium nanodroplets

et al. 2016

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“…[1,2] Low-energy electrons (LEEs) belong to the most important intermediates,since they are produced in significant quantities [2,3] and can directly attach to DNA and other biomolecules to form transient negative ions,which are unstable towards dissociation. [4] In DNA, dissociative electron attachment (DEA) can result in effective single and double strand breaks. [5,6] In radiation therapy,r adiosensitizers are used as therapeutics to enhance the radiation damage to the tumor tissue.…”

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confidence: 99%

Sensitizing DNA Towards Low‐Energy Electrons with 2‐Fluoroadenine

et al. 2016

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2-Fluoroadenine ((2F) A) is a therapeutic agent, which is suggested for application in cancer radiotherapy. The molecular mechanism of DNA radiation damage can be ascribed to a significant extent to the action of low-energy (<20 eV) electrons (LEEs), which damage DNA by dissociative electron attachment. LEE induced reactions in (2F) A are characterized both isolated in the gas phase and in the condensed phase when it is incorporated into DNA. Information about negative ion resonances and anion-mediated fragmentation reactions is combined with an absolute quantification of DNA strand breaks in (2F) A-containing oligonucleotides upon irradiation with LEEs. The incorporation of (2F) A into DNA results in an enhanced strand breakage. The strand-break cross sections are clearly energy dependent, whereas the strand-break enhancements by (2F) A at 5.5, 10, and 15 eV are very similar. Thus, (2F) A can be considered an effective radiosensitizer operative at a wide range of electron energies.

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“…As was shown in recent years, the radiation damage induced by the high‐energy primary radiation is mostly due to the effect of low‐energy secondary particles generated along the ionization track . Low‐energy electrons (LEEs) belong to the most important intermediates, since they are produced in significant quantities and can directly attach to DNA and other biomolecules to form transient negative ions, which are unstable towards dissociation . In DNA, dissociative electron attachment (DEA) can result in effective single and double strand breaks …”

Section: Figurementioning

confidence: 99%

Sensitizing DNA Towards Low‐Energy Electrons with 2‐Fluoroadenine

et al. 2016

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2-Fluoroadenine ( 2F A) is atherapeutic agent, which is suggested for application in cancer radiotherapy. The molecular mechanism of DNAr adiation damage can be ascribed to as ignificant extent to the action of low-energy (< 20 eV) electrons (LEEs), which damage DNAbydissociative electron attachment. LEE induced reactions in 2F Aa re characterized both isolated in the gas phase and in the condensed phase when it is incorporated into DNA. Information about negative ion resonances and anion-mediated fragmentation reactions is combined with an absolute quantification of DNAstrand breaks in 2F A-containing oligonucleotides upon irradiation with LEEs.T he incorporation of 2F A into DNAresults in an enhanced strand breakage.The strandbreak cross sections are clearly energy dependent, whereas the strand-break enhancements by 2F Aa t5 .5, 10, and 15 eV are very similar.T hus, 2F Ac an be considered an effective radiosensitizer operative at awide range of electron energies.Radiation therapy using high-energy photons,e lectrons,o r ions belongs to the most important methods used to treat cancer. As was shown in recent years,t he radiation damage induced by the high-energy primary radiation is mostly due to the effect of low-energy secondary particles generated along the ionization track. [1,2] Low-energy electrons (LEEs) belong to the most important intermediates,since they are produced in significant quantities [2,3] and can directly attach to DNA and other biomolecules to form transient negative ions,which are unstable towards dissociation. [4] In DNA, dissociative electron attachment (DEA) can result in effective single and double strand breaks. [5,6]

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The Effect of Solvation on Electron Attachment to Pure and Hydrated Pyrimidine Clusters

Cited by 53 publications

References 28 publications

Ion formation upon electron collisions with valine embedded in helium nanodroplets

Ion formation upon electron collisions with valine embedded in helium nanodroplets

Sensitizing DNA Towards Low‐Energy Electrons with 2‐Fluoroadenine

Sensitizing DNA Towards Low‐Energy Electrons with 2‐Fluoroadenine

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