The effect of spirulina gel on fibroblast cell number after wound healing

Rahmitasari, Fitria; J, Wisnu Setyari; Rachmat, Ester Arijani

doi:10.20473/j.djmkg.v44.i4.p192-195

Cited by 1 publication

(1 citation statement)

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“…5 Gel concentration of 12% spirulina most effectively to increase the number of fibroblast cells after tooth extraction guinea pig (Cavia cobaya). 6 Chitosan, product of chitin derivatives with the formula N-acetyl-D Glucosamine, is a cationic polymer that has number of monomers around 2000-3000 monomeric, non-toxic and molecular weight about 800 kD. Chitosan is produced from chitin deacetylation under alkaline conditions.…”

Section: Kata Kunci: Spirulina Kitosan Penyembuhan Luka Pembentukan T...mentioning

confidence: 99%

Spirulina chitosan gel induction on healing process of Cavia cobaya post extraction socket

Rostiny

Kuntjoro

Sitalaksmi

et al. 2014

Dent. J. (Majalah Kedokteran Gigi)

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Background: Prominent residual ridge is necessary to gain retention and stabilility for succesful prosthodontic treatment such as removable, fixed or implant. Spirulina is a natural substance that can help tissue healing and chitosan also a natural substance that reported to have the ability to help bone remodelling. The combination gel of spirulina and chitosan could be considered as an alternative material to maintain residual ridge height after tooth extraction. Purpose: The aim of study was to examine the effect of combination gel of Spirulina and chitosan on healing process of Cavia cobaya post tooth extraction socket by counting the amount of osteoclast, osteoblast and colagen as an indicator. Methods: Twenty eight cavia cobaya were divided into 4 groups. Insisive mandible extraction was done and the sockets were filled with 3% CMCNa for control groups, 3% spirulina chitosan 200 mg for group 1, 6% spirulina chitosan 200 mg for group 2, 12% spirulina chitosan 200 mg for group 3. After 30 days, histopathology examination was done by using microscope to count the amount of osteoclast, osteoblast and collagen. results: Data was analyzed by using Anova and Tukey HSD. For osteoclast, there was no significant different between every groups, while for osteoblast and collagen there was significant different between groups. The results showed that induction of combination gel spirulina chitosan was able to accumulate collagen fiber and resulting faster wound healing. Conclusion: Combination 12% gel spirulina chitosan 200 mg could be used as an alternative material for better bone remodeling after tooth extraction.

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Section: Kata Kunci: Spirulina Kitosan Penyembuhan Luka Pembentukan T...mentioning

confidence: 99%