The Effect of Splenectomy on Circulatory Adjustments to Hypoxaemia in the Anaesthetized Dog

Ffoulkes-Crabbe, D. J. O; Creighton, R. E.; Volgyesi, G. A.; Steward, David J.; Nisbet, H. I. A.

doi:10.1093/bja/48.7.639

Cited by 4 publications

(1 citation statement)

References 7 publications

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“…Interestingly, the latent linkages among spleen, hemodynamic and cardiac function had been explored but the complete insights were not yet elucidated. In splenectomized dogs, they may encounter with the anemic situation, high blood viscosity, temporary thrombocytosis and augmentations of heart rate and left ventricular systolic pressure (Elenes et al, 1964;Hirsh and Dacie, 1966;Ffoulkes-Crabbe et al, 1976;Robertson et al, 1981). Besides, arrhythmia is a serious complication in splenectomized dogs (Slatter, 2002).…”

Section: Cardiovascular Complication After Splenectomymentioning

confidence: 99%

Alterations in dispersion of cardiac repolarization and autonomic balance in the splenectomized dog

Pastarapatee

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Ventricular premature contraction (VPC) in the splenectomized dogs remains a major concern during post-operative period since it may progress to fatal arrhythmia, ventricular fibrillation (VF). Twelve splenectomized dogs were recruited in the present study and further divided into 2 groups according to the number of VPC/24 hours, low VPC (n=6) and high VPC groups (n=6). None of the dogs received antiarrhythmic drug or digoxin prior to the study. Holter device was attached for 30 minutes in pre-operative period and 9 days after surgery while during the post-operative period, ECG signals were continuously recorded throughout 72 hours. Blood samples were collected at both pre-operative and post-operative (day 2 and 9) for complete blood count (RBC, Hct, platelet, WBC), blood chemical profiles (ALT, ALP, BUN, creatinine, total protein, Na+, K+) and concentrations of norepinephrine (NE) and epinephrine (E). The results revealed that the number of VPC was highest at day 3 (p<0.05) then declined at day 9. The HR in all dogs and low VPC group were decreased (p<0.05) compared with pre-operative period whereas SBP was unchanged. The Tp-Te was significantly increased on day 2 and day 1 (p<0.05) in low and high VPC groups, respectively. For time domain analysis of HRV, SDANN, SDNN index, SDNN, pNN50 and RMSSD tended to enhance after surgery compared with pre-operative period. In frequency domain analysis, HF and TP in all dogs increased having the decreased LF/HF after operation when comparing with pre-operative period. Nonetheless, lower HF and higher LF/HF were observed in high VPC group on day 2 (p<0.05) compared with low VPC group. NE and E increased significantly on day 2 after surgery in all dogs with the statistical significance of NE in high VPC group (p<0.05) compared with pre-operation. Additionally, concentrations of NE and E obtained from pre-operative, day 2 and day 9 after surgery were related to the number of VPC in all dogs and high VPC group (p<0.05). This study demonstrated that the splenectomized dogs had VPC after surgery. The catecholamine and Tp-Te were enhanced postoperatively along with enhanced cardiac ANS activity, particularly parasympathetic modulation. However, parasympathetic modulation in low VPC group was more dominant than high VPC group.

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Section: Cardiovascular Complication After Splenectomymentioning

confidence: 99%

Alterations in dispersion of cardiac repolarization and autonomic balance in the splenectomized dog

Pastarapatee

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Preliminary investigation into change in packed cell volume (PCV) after administration of two premedication protocols followed by induction and maintenance of anaesthesia in goats

Fernández¹,

Labberté²,

Lacey³

et al. 2022

Emerging Animal Species

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Successful derotation of a splenic torsion in a racing greyhound

Goldsmid

Davis

Pechman

1994

J of Small Animal Practice

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A two‐year‐old male racing greyhound was presented to the Sydney University Veterinary Hospital with a six‐week history of intermittent gastric dilatation. Abdominal radiography and ultrasonography were suggestive of splenic torsion without gastric dilatation. Exploratory ceoliotomy confirmed a 540° clockwise rotation of the spleen. Derotation of the spleen was performed and thrombosis was not present in the splenic vessels. Epinephrine was injected into the splenic parenchyma to aid in splenic contraction. The spleen was left in situ. The greyhound made an uneventful recovery and has won several races in the 10‐month follow‐up period without further problems.

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The Effect of Splenectomy on Circulatory Adjustments to Hypoxaemia in the Anaesthetized Dog

Cited by 4 publications

References 7 publications

Alterations in dispersion of cardiac repolarization and autonomic balance in the splenectomized dog

Alterations in dispersion of cardiac repolarization and autonomic balance in the splenectomized dog

Preliminary investigation into change in packed cell volume (PCV) after administration of two premedication protocols followed by induction and maintenance of anaesthesia in goats

Successful derotation of a splenic torsion in a racing greyhound

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