The effect of starvation on tissue adenosine 3′–5′ monophosphate levels

Selawry, Helena; Gutman, R.; Fink, Gloria; Recant, Lillian

doi:10.1016/0006-291x(73)90528-7

Cited by 61 publications

(28 citation statements)

References 21 publications

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“…A role for islet cyclic AMP has been implied by recent studies (18)(19)(20). Contrary to the findings of Selawry et al (19) and in agreement with Capito and Hedeskov (20), the basal content of cyclic AMP was not significantly reduced in islets of starved animals (Table III). However, in agreement with the latter authors (20), glucose stimulated a lesser increase of cyclic AMP in islets of 48 h starved than fed animals.…”

Section: Discussionsupporting

confidence: 79%

“…Howell et al (18) have shown that basal as well as glucagon-stimulated adenylate cyclase activity is decreased in islets of 48-h starved rats, and these authors have suggested that glucose, or a glucose metabolite, may exert long-term effects on this enzyme. Selawry et al (19) found a decreased content of cyclic AMP in islets of rats starved for 48-72 h, and Capito and Hedeskov (20) observed that glucose Perifusion experiments. For each experiment 40 islets were transferred into each of two perifusion chambers in parallel, and the insulin content of two groups of 40 islets was also measured after acid-ethanol extraction (23).…”

Section: Introductionmentioning

confidence: 98%

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Insulin release and cyclic AMP accumulation in response to glucose in pancreatic islets of fed and starved rats.

Rabinovitch¹,

Grill²,

Renold³

et al. 1976

J. Clin. Invest.

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A B S T R A C T The dose as well as the time kinetics of insulin and adenosine-3',5'-monophosphate (cyclic AMP) responses to glucose were compared in pancreatic islets of fed and starved rats. There was a preferential impairment of the early phase of glucose-induced insulin release in perifused islets of rats starved for 16 and 48 h. Similarly, the accumulation of 3H cyclic AMP in islets prelabeled with 3H-2-adenine was less in islets of 48 h starved than fed rats, during the first 10-min of stimulation with 26.7 mM glucose in the presence of 0.1 mM of the phosphodiesterase inhibitor, 3-isobutyl-1-methylxanthine, whereas at 30 and 60 min 3H cyclic AMP responses to glucose were similar in fed and starved islets. Also, in 10-min incubations with glucose 3.3, 6.7, 10.0, 13.3, and 26.7 mM without and with 0.1 mM and 1.0 mM 3-isobutyl-1-methylxanthine, insulin release correlated strongly with the accumulation of 3H cyclic AMP in the islets of fed as well as starved rats. The thresholds for glucose-induced insulin and 3H cyclic AMP responses were higher and the maximal responses were lower in starved than fed islets. Preincubation of islets of 48-h starved rats with 16.7 mM glucose for 60 min corrected the impaired insulin and 3H cyclic AMP responses to glucose. Starvation-induced impairment of insulin Part of this work was previously reported in abstract form, Rabinovitch, A. 1975. Adenosine 3',5'-monophosphate (cAMP) and insulin responses to glucose in isolated pancreatic islets from fed and fasted rats. Diabetologia.

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Section: Discussionsupporting

confidence: 79%

Section: Introductionmentioning

confidence: 98%

Insulin release and cyclic AMP accumulation in response to glucose in pancreatic islets of fed and starved rats.

Rabinovitch¹,

Grill²,

Renold³

et al. 1976

J. Clin. Invest.

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“…Although addition of cyclic AMP analogues to intact hepatocytes or the elevation of endogenous cyclic AMP concentrations does not appear to affect either the phosphorylation or the membrane association of CT with the membrane [164], it has been suggested that the effects of increased cellular cyclic AMP could be mediated through a decrease in membrane content of DAG [158]. Therefore, it may be relevant that in starved-rat liver the activity of cyclic AMP-dependent protein kinase and the concentration of cyclic AMP are increased, and that during refeeding they are both rapidly decreased [68,165]. Evidently experiments need to be conducted, on liver samples obtained in situ, to find out directly whether changes in membrane DAG content and translocation of CT are involved in the acute increase in the partitioning of TAG towards phospholipids.…”

Section: Partitioning Of Dag Between Phospholipid and Tag Synthesismentioning

confidence: 99%

Role of insulin in hepatic fatty acid partitioning: emerging concepts

Zammit

1996

Biochemical Journal

115

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“…The factors responsible for the altered insulin secretion seen following a glucose stimulus in starved rats are not known, though decreased content of cyclic AMP [18] and decreased adenylate cyclase [19] activity have been reported in isolated pancreatic islets of starved animals. Other factors may well be involved in starvation, such as alterations in glucose-inducible enzymes participating in the metabolism and recognition of glucose as an insulinotropic agent, tIowever, at the present time, there are no definitive data to support these speculations as they relate to patterns of insulin response in starvation.…”

Section: Time (Minutes)mentioning

confidence: 99%

Glucose-induced insulin release patterns: Effect of starvation

et al. 1974

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Summary. Continuous glucose infusions over a 60 rain period were carried out in 24 human subjects. A priming dose of 0.33 gm glueose/kg was followed by a constant infusion of 20 mg glueose/kg/min. The glucose-stimulated insulin release curves were biphasic (Phase I and II) in all subjects. The diabetics, compared with normal controls, showed decreased total insulin release with a greater decrement in phase I. Starvation of normal subjects for 48 h resulted in decreased insulin release, though Phases I and II were equivalently diminished. Rats were starved for 48 h and their panereata studied in the isolated panereas perfusion system. Following glucose stimuli, insulin release showed a pattern similar to that of diabetics, namely, decreased total insulin and a greater decrease in phase I than II. It is postulated that this period of starvation for a small animal was far more pronounced than that in man. The altered insulin secretory pattern in prolonged starvation is an additional manifestation of "starvation diabetes" and suggests the possibility of similar defects in starvation and diabetes.

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The effect of starvation on tissue adenosine 3′–5′ monophosphate levels

Cited by 61 publications

References 21 publications

Insulin release and cyclic AMP accumulation in response to glucose in pancreatic islets of fed and starved rats.

Insulin release and cyclic AMP accumulation in response to glucose in pancreatic islets of fed and starved rats.

Role of insulin in hepatic fatty acid partitioning: emerging concepts

Glucose-induced insulin release patterns: Effect of starvation

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