The effect of steatosis and fibrosis on blunt force vulnerability of the liver

Simon, Gábor; Poór, Viktor Soma; Heckmann, Veronika; Kozma, Zsolt; Molnár, Tamás

doi:10.1007/s00414-019-02245-4

Cited by 5 publications

(3 citation statements)

References 30 publications

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“…The first, mechanical approach might be based on an increased resilience against pressure trauma as the dominance of the fibrotic elements. A similar pattern was recently identified in blunt liver trauma ( 22 ).…”

Section: Discussionsupporting

confidence: 85%

Pneumothorax/pneumomediastinum and pre-existing lung pathology in ventilated COVID-19 patients: a cohort study

Kecskes¹,

Szabo²,

Sutori³

et al. 2022

J Thorac Dis

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Background: There is an increasing number of reports on developing pneumothorax/pneumomediastinum among severe acute respiratory syndrome coronavirus disease 2019 (SARS-COVID-19) patients. The aim of our study was whether pre-existing diffuse lung pathology increases visceral pleural vulnerability resulting in pneumomediastinum and pneumothorax among mechanically ventilated COVID-19 patients? Methods: A total of 138 consecutive COVID-19 patients admitted to the Intensive Care Unit of Petz Aladár University Teaching Hospital between 1st March 2020 and 1st February 2021 were included.Sixty/138 (43.48%) patients had one or more computer tomography scans of the chest. Analysis was focused on the image defined lung conditions during artificial ventilation.Results: Thirteen out of 60 ventilated patients developed pneumothorax or pneumomediastinum proven by computer tomography (9.42%). Three/13 patients suffered from pre-existing lung parenchyma pathology, while 10/13 had only COVID-19 infection-related image abnormality. Forty-three/60 patient had healthy lung pre-COVID. Kruskal-Wallis test, Spearman correlation and Cox regression calculations did not reveal any statistically significant result proving increased vulnerability during pressure support therapy and visceral pleural breakdown in patients with pre-existing lung pathologies.Conclusions: Pre-existing lung pathology does not increase the risk of onset of pneumothorax or pneumomediastinum in comparation with previously healthy lungs of ventilated COVID-19 patients.

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Section: Discussionsupporting

confidence: 85%

Pneumothorax/pneumomediastinum and pre-existing lung pathology in ventilated COVID-19 patients: a cohort study

Kecskes¹,

Szabo²,

Sutori³

et al. 2022

J Thorac Dis

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show abstract

“…Somewhat counterintuitively, it has previously been demonstrated that diseases of the liver parenchyma such as steatosis or fibrosis correlate with resistance to blunt force injury in vitro and in vivo. 5,6 Further, it has been established that chronic cholecystitis results in fibrosis of the gallbladder wall and subserosal layer of the cystic plate. 7 Therefore, we postulate that the fibrosed attachment of the gallbladder to the cystic plate was able to withstand greater force than the hepatic parenchyma, resulting in preferential avulsion of the latter.…”

Section: Discussionmentioning

confidence: 99%

“…Regarding our case, histologic examination revealed an acalculous gallbladder and chronic cholecystitis, as well as hepatic steatosis. Somewhat counterintuitively, it has previously been demonstrated that diseases of the liver parenchyma such as steatosis or fibrosis correlate with resistance to blunt force injury in vitro and in vivo 5,6 . Further, it has been established that chronic cholecystitis results in fibrosis of the gallbladder wall and subserosal layer of the cystic plate 7 .…”

Section: Discussionmentioning

confidence: 99%