The Effect of Steroid Treatment on Corrosive Oesophageal Burns in Children*

Abstract

A retrospective study was done on corrosive oesophageal burns to ascertain the preventive effect of corticosteroids on stricture development. Within the last 12 years 351 children were admitted to our medical centre with a history of corrosive agent ingestion. In 235 of these the diagnosis of oesophageal burn was confirmed by means of oesophagoscopy. Children admitted within the first 48 hours received steroid, antibiotic and fluid therapy while fluid and antibiotics were given, if needed, in the rest. Forty-six of the children were lost to follow-up. The type of corrosive agent, the admission period, the degree of the burn and the stricture development were used as parameters. Stricture development was found statistically significant in late admitted patients vs. early admissions. This retrospective study suggests the effectiveness of corticosteroid treatment in preventing the stricture development.

Inhibition of iNOS with S-methylisothiourea was impaired in wound healing in caustic esophageal burn

“…However, none of the treatment modalities are effective for severe caustic esophageal burns [3]. Several researchers tried various substances such as were steroids, Vitamin C and E, heparin, caffeic acid phenethyl ester (CAPE), epidermal growth factor, interferon gamma, penicillamine, estradiol, and progesterone, in order to reduce the risk of stricture formation [2][3][4][5][6][7][8]. However, there is a paucity of data about the pathopysiology of caustic esophageal burn.…”

“…Several types of nonsurgical management have been proposed for the strictures [1][2][3][4][5]. These are dilatation, esophageal stent placement, total parenteral nutrition, steroids, and antibiotic therapy.…”

Role of caffeic acid phenethyl ester, an active component of propolis, against NAOH-induced esophageal burns in rats

“…However, none of the treatment modalities are effective for severe caustic esophageal burns [24]. Several researchers tried various substances such as were steroids, Vitamins C and E, heparin, CAPE, epidermal growth factor, interferon gamma, penicillamine, estradiol, and progesterone, in order to reduce the risk of stricture formation [13,14,21,22,24,25]. However, there is a paucity of data about the pathopysiology of caustic esophageal burn.…”

“…Several types of nonsurgical management have been proposed for the strictures [8,13,24,25]. These are dilatation, esophageal stent placement, total parenteral nutrition, steroids, and antibiotic therapy.…”

The use of mitomycin C in caustic esophagitis in rats

“…In the study of Keskin et al 10 , sodium hydroxide (NaOH) was the only caustic agent involved in all patients with esophageal stenosis requiring surgical replacement of the organ. Thus, in the experimental studies, NaOH has been used as a caustic agent [8][9] .…”