The Effect of Steroidal Extract of Nerium oleander on the Liver Tissue Structure of Albino Mice

Al-Saadi, Sahar A. A. Malik; Derawi, Karim H. Al; Alrasool, Shiama Abd

doi:10.9790/3008-1202015255

Cited by 2 publications

(2 citation statements)

References 4 publications

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“…One of the mechanisms of plant extracts is the process of inhibiting the synthesis of purine and pyrimidine [46,47]. Under a microscope, liver sections were examined for histological alterations such as When compared to the control, there was greater inflammation and damage of the liver architecture [48].…”

Section: B Histopathology Of the Livermentioning

confidence: 99%

Phytochemical constituents of bark essential oils of Cinnamomum zeylanicum Blume and effects on liver tissue of rats

Duaa Abd Alazem Amran,

Karim H. Al-Derawi,

Al-Saadi

2023

UTJsci

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Cinnamomum zeylanicum Blume is an evergreen tropical tree belonging to the Lauraceae family; it is a useful plant in traditional and modern medicines. Essential oils of Cinnamomum zeylanicum were prepared and identified using gas chromatography–mass spectrometry (GC-MS). For histological study 80 adult male rats were employed in this study. It is the same weight (30 ±5 gm) and 75 days in age. The animals were divided into 4 groups, with ten rats in each group. The results indicated that C. zeylanicum bark contained 27 different phytochemical components. The main components included Cinnamaldehyde (2-Propenal, 3-phenyl-) (46.46%), 9-Methoxybicyclo, [6.1.0] nona-2,4,6-triene (31.31%), alpha-, Muurolene (7.14%) and Copaene (1.63%). Sections of livers were examined for histological abnormalities, such as the breakdown of the liver architecture and increased inflammation, in comparison to control samples, some hepatocytes were swollen with pyknotic, large nuclei and dilated sinusoids. As well as in the rats treated with noticed sever congestion of central vein (CV), degeneration and sluggish of endothelial lining larger, Bile ducts hyperplasia and necrotic hepatocytes. It can be deduced that the main component of cinnamon bark oil is cinnamaldehyde and the liver displayed some tissue changes, including hepatocyte necrosis and the existence of steatosis foci. Histological and cellular changes in liver tissue were dramatically attenuated by C. zeylanicum essential oil.

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Section: B Histopathology Of the Livermentioning

confidence: 99%

Phytochemical constituents of bark essential oils of Cinnamomum zeylanicum Blume and effects on liver tissue of rats

Duaa Abd Alazem Amran,

Karim H. Al-Derawi,

Al-Saadi

2023

UTJsci

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“…Z. officinale is one of these plants. Furthermore, medicinal plants can be very effective at preventing the spread of antibiotic resistance, both directly and indirectly through their antibacterial, antiviral, antifungal, and antiparasitic properties and indirectly by reducing antibiotic resistance (Jawad, 1997;Al-Malak, 2004;Al-Saadi et al 2017;Castronovo, 2021).…”

Section: Introductionmentioning

confidence: 99%

The protective effects of <em>Zingiber officinale</em> essential oils extract against Atenolol induced adrenal gland in rats (<em>Rattus norvigicus</em>)

Amran,

Al- Derawi,

Al-Saadi

2024

Multidiscip. Sci. J.

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Zingiber officinale Roscoe is a perennial herb belonging to the Zingiberaceae family. The chemical compounds were identified by Gas chromatography‒mass spectrometry, the results showed that 38 components found in Z. officinale, beta-Sesquiphellandrene had the highest percentage was (28.94%), followed by 2- Butanone, 4-(2,6,6-trimethyl-2-cyclohexen-1-yl)-, (R)- (16.82%), alpha.-Farnesene (14.45%). The rest of the compounds constituted a smaller percentage, they were represented by Zingiberene, beta.-Phellandrene, Camphene, 1,8-Cineole, Alpha-Cedrene, Elemol, and Shogaol. Histological sections of the adrenal gland treated with atenolol drug showed that the cortex composed of atrophied zona granulosa, vascularized and inflamed zona fasciculate and sever inflammation of zona reticularis, the medulla appear with mild hemorrhage extended between the chromaffin cells, the parenchyma of the medulla consist of loosely, disorganized into clusters and cords resemble the epithelial, the cells large is size, polyhedral shape and appear empty in sections separated by sinusoidal capillaries while the deep layer is zona reticularis formed by pink stained cells and irregular arrangement. While in adrenal gland treated with Z. officinale showed more normal histological sections, so that treated with (atenolol and Z. officinale) showed mild moderate changes in different adrenal zona, the zona glomerulosa showed normal structure, small cluster beneath the capsule with crowded nuclei, mild hemorrhage area and the cells appeared resemble the lipoblasts.

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The Effect of Steroidal Extract of Nerium oleander on the Liver Tissue Structure of Albino Mice

Cited by 2 publications

References 4 publications

Phytochemical constituents of bark essential oils of Cinnamomum zeylanicum Blume and effects on liver tissue of rats

Phytochemical constituents of bark essential oils of Cinnamomum zeylanicum Blume and effects on liver tissue of rats

The protective effects of <em>Zingiber officinale</em> essential oils extract against Atenolol induced adrenal gland in rats (<em>Rattus norvigicus</em>)

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