The effect of steroids on the circulating lymphocyte population — VI. Studies of the thoracic duct T- and B-lymphocyte populations after neonatal thymectomy and prednisolone treatment. An immunofluorescence

Hedman, L; Röckert, L; Lundin, Per

doi:10.1016/0192-0561(84)90055-9

Cited by 7 publications

(5 citation statements)

References 28 publications

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“…Anti-inflammatory effects are postulated but it remains unclear to what extent inflammation contributes to this disease. Similarly, while it is demonstrated that moderate doses of corticosteroids result in profound decreases in circulating peripheral blood lymphocytes, 54 as well as thoracic duct lymphocyte number and overall thoracic duct flow, 55 it is unclear if the magnitude and duration of these effects are sufficient to affect clinical response in protein-losing enteropathy. Unfortunately, as with heparin therapy, the side effects of corticosteroid use can be prohibitive.…”

Section: Discussionmentioning

confidence: 99%

Protein-losing enteropathy: integrating a new disease paradigm into recommendations for prevention and treatment

Meadows

Jenkins

2011

Cardiol Young

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Protein-losing enteropathy is a relatively uncommon complication of Fontan procedures for palliation of complex congenital cardiac disease. However, the relative infrequency of protein-losing enteropathy belies the tremendous medical, psychosocial and financial burdens it places upon afflicted patients, their families and the healthcare system that supports them. Unfortunately, because of the complexity and rarity of this disease process, the pathogenesis and pathophysiology of protein-losing enteropathy remain poorly understood, and attempts at treatment seldom yield long-term success. The most comprehensive analyses of protein-losing enteropathy in this patient population are now over a decade old, and re-evaluation of the prevalence and progress in treatment of this disease is needed. This report describes a single institution experience with the evaluation, management, and treatment of protein-losing enteropathy in patients with congenital cardiac disease in the current era, follows with a comprehensive review of protein-losing enteropathy, focused upon what is known and not known about the pathophysiology of protein-losing enteropathy in this patient population, and concludes with suggestions for prevention and treatment.

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Section: Discussionmentioning

confidence: 99%

Protein-losing enteropathy: integrating a new disease paradigm into recommendations for prevention and treatment

Meadows

Jenkins

2011

Cardiol Young

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“…Schuyler, et al 16 found that in rats, prednisone caused a non-selective depletion of all T-cell subclasses from the pool of circulating lymphocytes but did not affect the helper: suppressor ratio. In contrast, Hedman et al 17 found that while the T and B-cells were reduced, there was a greater reduction in the subset defined by the 0X8 antibody (suppressor/cytotoxic) than in the W3/25-defined group (helper/inducer). In humans, steroids produce generalized lymphocytopenia but there is apparently a greater decrease in the helper subset (T4) than in the suppressor subset (T8), causing a decrease in the helpensuppresser ratio.…”

Section: Discussionmentioning

confidence: 85%

Treatment of Experimental Allergic Neuritis With Prednisolone

Feasby¹,

Gilbert

Hahn³

et al. 1987

Can. j. neurol. sci.

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Abstract:Experimental allergic neuritis (EAN) in Lewis rats was treated with prednisolone given prophylactically or therapeutically. Rats treated from the time of immunization with myelin or after the establishment of clinical disease improved more rapidly than controls. Treatment at the onset of clinical signs resulted in less severe disease and more rapid recovery. Rats treated just prior to the onset of clinical signs (day 10) did not develop significant clinical disease and appeared to have less inflammation in their nerves and nerve roots on microscopic examination.

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“…Although early evidence suggested that glucocorticoids induce lysis of blood lymphocytes in certain species (eg mouse, rat 31), several studies indicated that glucocorticoids alter cell distribution rather than increase destruction 36, 37. Since leukocyte trafficking between the various body compartments is critical for the efficiency of the immune response, the reduction in peripheral blood leukocytes could simply be due to redistribution within other immune compartments and does not necessarily reflect compromised immune function.…”

Section: Discussionmentioning

confidence: 99%

The long‐term effects of perinatal glucocorticoid exposure on the host defence system of the respiratory tract

Theogaraj

John

Dewar

et al. 2006

The Journal of Pathology

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Glucocorticoids are used to mature the fetal lung at times of threatened premature delivery. These drugs modify leukocyte profiles when administered in adulthood, but their effects on the mature host defence system following administration during the perinatal period are incompletely understood. In this study, the long-term effects of perinatal dexamethasone exposure on rodent host defence cells in the pulmonary airspaces, the perivascular compartment of the lung, and the blood were investigated. Rats were treated prenatally (gestational days 16-19) or neonatally (postnatal days 1-7) by inclusion of dexamethasone in the mothers' drinking water (1 microg/ml). The pups were then allowed to develop to adulthood (P60-80), at which time respiratory tissues were collected for light and electron microscopy and bronchoalveolar lavage (BAL), and blood for cell count and fluorescent activated cell-sorting (FACS) analysis. Prenatal treatment had no effect on any parameter examined. Following neonatal dexamethasone exposure, light microscopy of the lung tissue revealed a significant reduction in the number of cells in the perivascular space in both the central and the peripheral regions of the adult lung, but no differences in the number of cells in the airspaces. Neonatal dexamethasone exposure was also characterized by a significant reduction in the total number of white cells in the peripheral blood in adulthood and in particular, the number of lymphocytes relative to neutrophils was significantly reduced at maturity in these animals. The results show that neonatal, but not prenatal, dexamethasone exposure significantly alters the distribution of host defence cells in the blood and lung at maturity compared with control animals. The early neonatal period is characterized by the stress hyporesponsive period in the rat, when endogenous glucocorticoid levels are very low. Therefore, exogenous glucocorticoids administered during this time are likely to have marked "programming" effects on glucocorticoid-sensitive tissues.

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The effect of steroids on the circulating lymphocyte population — VI. Studies of the thoracic duct T- and B-lymphocyte populations after neonatal thymectomy and prednisolone treatment. An immunofluorescence

Cited by 7 publications

References 28 publications

Protein-losing enteropathy: integrating a new disease paradigm into recommendations for prevention and treatment

Protein-losing enteropathy: integrating a new disease paradigm into recommendations for prevention and treatment

Treatment of Experimental Allergic Neuritis With Prednisolone

The long‐term effects of perinatal glucocorticoid exposure on the host defence system of the respiratory tract

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