The effect of stimulus strength on the jaw-jerk response in man.

Lewis, George L.; Pilcher, Robin; Yemm, R.

doi:10.1136/jnnp.43.8.699

Cited by 11 publications

(3 citation statements)

References 11 publications

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“…Additional OME items were added based on our previous findings of abnormal articulator range of motions and speeds in bulbar disease (37)(38)(39)(40)(41). A "jaw jerk reflex" item was also added based on high relevance to ALS, despite previous concerns about the reliability of this item (42,43). A total of 16 OME items were included in the first draft of ALS-BDI: 14 of those items assessed the tongue, lips/face (combined) and jaw for weakness, range of motion, speed, atrophy, and fasciculation (excluding jaw fasciculations), and the remaining two items assessed facial and jaw jerk reflexes.…”

Section: Resultsmentioning

confidence: 99%

Face and content validation of the amyotrophic lateral sclerosis—Bulbar dysfunction index (ALS-BDI)

et al. 2023

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PurposeEarly detection and tracking of bulbar dysfunction in amyotrophic lateral sclerosis (ALS) are critical for directing management of the disease. Existing physiological assessments of bulbar dysfunction are often inaccessible and cost-prohibitive for clinical application. Existing clinical assessments are limited. The overall goal of our research is to develop a brief and reliable, clinician-administered assessment tool, the ALS Bulbar Dysfunction Index (ALS-BDI) to evaluate bulbar dysfunction. The aim of this study was to establish content and face validity of the ALS-BDI through item generation and reduction, including item scoring.MethodsThe design of the ALS-BDI followed guidelines outlined by the COnsensus-based Standards for the selection of health Measurement INstruments (COSMIN). The design stage of the ALS-BDI involved two steps: (Step 1) the generation of candidate items from a literature review of commonly used clinical tools, and selection of items following a review of item reliability and item relevance and expert consensus; (Step 2) the assessment of their content and face validity via online survey feedback from experts (n = 35). The initial design was followed by a semi-structured cognitive interview with Speech-Language Pathologists (n = 5) to finalize a testable draft of the instrument.ResultsTwo drafts of the ALS-BDI were developed. The first draft contained 48 items, after a review of existing clinical tools for their relevance to bulbar dysfunction in ALS. Of the 48 items, 35 items were retained after surveying experts and clinician users for their relevance, feasibility, interpretability, and appropriateness. The second draft of the ALS-BDI contained 37 items, due to one item splitting, based on users cognitive interviews.ConclusionsThe ALS-BDI described in this study aims to provide a brief and reliable, clinician-administered assessment tool to evaluate bulbar dysfunction in patients with ALS. Future research will evaluate the psychometric properties of this tool including its reliability, validity, and responsiveness to change over time.

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Section: Resultsmentioning

confidence: 99%

Face and content validation of the amyotrophic lateral sclerosis—Bulbar dysfunction index (ALS-BDI)

et al. 2023

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“…The masseteric silent period is extensively studied [1]. The set-ups for the jaw-jerk studies examining the duration of the masseteric spindle -induced silent period necessitates the pre-existing clenching-activation of jaw muscles prior to the chin tapping, which is the actual stretch-stimulus [ [42]]. Studies examining the duration of masseteric silent period employ pre-existing masseteric activity before the controlled tap-or push-stimulus [35,36] produced consistent and repeatable measurements of the duration of the silent period.…”

Section: During the Forceful Compressive Phase Of MMM The Inhibitory ...mentioning

confidence: 99%

The Neurophysiology of Jaw-Closing Kinematics – a Mandible-Meets-Maxilla Narrative

Vaahtoniemi

2023

Preprint

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A stable match, an intercuspated maxilla-mandible relation is the universally accepted goal for dental restorative interventions, yet the underlying sensorimotor mechanisms to achieve this goal in the natural jaw closure remains to be elucidated. Dentists have intuitively regarded peripheral sensory innervation from tooth contacts as a significant control element for jaw muscle actions, both in the state of health and in cases of pathological dysfunction. However, therapeutical interventions for reshaping the dental arch anatomy and jaw relations have not always been successful. Repetitive masticatory chewing cycles, swallowing, talking, as well as volitional jaw-opening and -closing involve stereotyped neural commands from the central nervous system that are modulated in reaction to the sensory afferent feedback from the peripheral neurons and their sensor organs. The aim of this article is to describe, on a fraction of a second time-scale, the minuscule tilts and kinematic events of mandible during the making of a stable match with maxilla. Evidence of the importance of tooth contacts as the sensorimotor motivation of each of the successive kinematic steps of the “mandible-meets-maxilla-narrative” are discussed.

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“…The study recognized the major target proteins including lipoprotein metabolism, nuclear transport and ribonucleoprotein, followed by the possible binding interfaces. To the end, a network study showed 332 human proteins interacting with SARS-CoV-2 viral genes and developed a first interactome model for SARS-CoV-2 and human protein interactions (Gordon et al 2020 ). Still at present, scientific community struggling with proper knowledge of the molecular basis of SARS-CoV-2 disease prevents a complete assessment of small lead candidates for host-directed therapies.…”

Section: Systems Biology-based Approaches For Identification Of Targementioning

confidence: 99%

Molecular targets and system biology approaches for drug repurposing against SARS-CoV-2

2020

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Background COVID-19, a pandemic declared by WHO, has infected about 39.5 million and killed about 1.1 million people throughout the world. There is the urgent need of more studies to identify the novel drug targets and the drug candidates against it to handle the situation. Main body To virtually screen various drugs against SARS-CoV-2, the scientists need the detail information about the various drug targets identified till date. The present review provides the information about almost all the drug targets, including structural and non-structural proteins of virus as well as host cell surface receptors, that can be used for virtual screening of drugs. Moreover, this review also focuses on the different network analysis tools that have been used for the identification of new drug targets and candidate repurposable drugs against SARS-CoV-2. Conclusion This review provides important insights of various drug targets and the network analysis tools to young bioinformaticians and will help in creating pace to the drug repurposing strategy for COVID-19 disease.

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The effect of stimulus strength on the jaw-jerk response in man.

Cited by 11 publications

References 11 publications

Face and content validation of the amyotrophic lateral sclerosis—Bulbar dysfunction index (ALS-BDI)

Face and content validation of the amyotrophic lateral sclerosis—Bulbar dysfunction index (ALS-BDI)

The Neurophysiology of Jaw-Closing Kinematics – a Mandible-Meets-Maxilla Narrative

Molecular targets and system biology approaches for drug repurposing against SARS-CoV-2

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