Objective: The current study aims to know the strategic renewal and its impact on organizational brilliance, the mediating role of the strategic response through a survey of the opinions of a sample of employees at working in private universities in the Middle Euphrates region. Design/Methodology: A variety of questions were used to identify the study's problem, the most essential of which are (Is the low level of organizational brilliance attributable to inadequate strategic innovation or a lack of investment in effective strategic response?) and its significance to them, as well as the form and amount of benefit in the banking industry among the institutions questioned. The study population in (the governorates of the Middle Euphrates), where the number of questionnaires disseminated reached (135), and the number of questionnaires acceptable for analysis reached (124) out of a total of (135) questionnaires recovered. The current study aimed to investigate a variety of primary and sub-hypotheses about correlation and effect connections among the variables under consideration. Many statistical methods (normal distribution, arithmetic mean, exploratory and confirmatory factor analysis, and structural equation modeling) were used to answer the study problem's questions and achieve the set objectives, as well as to process the data, using the statistical program SPSS V25 and the program Amos V.25. Theoretical results: There is a knowledge gap in interpreting the nature of the link between the variables of the current study, which are represented by the independent variable, strategic renewal, the mediating variable, strategic reaction, and the dependent variable, organizational brilliance. Practical results: The study produced a number of findings, the most significant of which is that, by mediating the strategic response variable, the organizational brilliance variable affects and is connected to the strategic renewal variable.