The Effect of Streptomycin and Colistin on Myasthenic Patients

Herishanu, Y.

doi:10.1159/000103501

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1971

2008

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Cited by 5 publications

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“…Patients suffering from Myasthenia Gravis showed aggravation of their condition after receiving antibiotics such as streptomycin and colistin sul fate [8,9].…”

Section: Discussionmentioning

confidence: 99%

The Electromyographic Changes Induced by Antibiotics

Herishanu¹,

Taustein²

1971

Stereotact Funct Neurosurg

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Thirthy patients who were not suffering from any neuromuscular disease received therapeutic doses of ampicillin, erythromycin and tetracycline hydrochloride; electromyographic recordings were performed before, during and after the administration of these antibiotics. An electromyographic myasthenic-like picture was obtained during ampicillin and erythromycin administration; this picture normalized after the discontinuation of the antibiotics. A marked facilitation in the size of the muscle action potential during supramaximal repetitive nerve stimulation was observed in control patients from the first 2 groups. This finding points to a presynaptic effect of erythromycin and ampicillin. Tetracycline hydrochloride did not alter the electromyographic recording.

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“…Patients suffering from Myasthenia Gravis showed aggravation of their condition after receiving antibiotics such as streptomycin and colistin sul fate [8,9].…”

Section: Discussionmentioning

confidence: 99%