The effect of streptozotocin-induced diabetes mellitus on substance P and calcitonin gene-related peptide expression in the rat trigeminal ganglion

Troger, Josef; Humpel, Christian; Kremser, B.; Kralinger, Martina; Teuchner, Barbara; Kunze, Christian; Philipp, Wolfgang; Kieselbach, G.

doi:10.1016/s0006-8993(99)01837-5

Cited by 21 publications

(23 citation statements)

References 41 publications

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“…And, a diabetes-associated depletion of neuropeptides in the trigeminal ganglion (TG) has already been confirmed. Diabetic corneal abnormalities may reflect a loss of trophic influences from the trigeminal nerve10. So, target delivery to the trigeminal nerve may be beneficial for the treatment of the diabetic keratopathy.…”

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confidence: 99%

Intranasal delivery of nanomicelle curcumin promotes corneal epithelial wound healing in streptozotocin-induced diabetic mice

Guo

et al. 2016

Sci Rep

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Corneal nerves are mainly derived from the ophthalmic branch of the trigeminal ganglion (TG). Corneal neuropathy contributes to epithelial degenerative changes in diabetic keratopathy. Efficient drug delivery to TG may be beneficial for the treatment of diabetic keratopathy. This article described intranasal delivery of nanomicelle curcumin to correct pathophysiological conditions in TG to promote corneal epithelial/nerve wound healing in streptozotocin-induced diabetic mice. A diabetic mice model with corneal epithelium abrasion was established. Ocular topical and/or intranasal nanomicelle curcumin treatments were performed, and treatment efficacy and mechanisms of action were explored. Results showed that intranasal nanomicelle curcumin treatment promoted corneal epithelial wound healing and recovery of corneal sensation. Enhanced accumulation of reactive oxygen species, reduced free radical scavengers, increased mRNA expressions of inflammatory cytokines, and decreased mRNA expressions of neurotrophic factors in the cornea and TG neuron were observed in diabetic mice with corneal epithelium abrasions. Intranasal nanomicelle curcumin treatment effectively recovered these pathophysiological conditions, especially that of the TG neuron, and a strengthened recovery was observed with ocular topical combined with intranasal treatment. These findings indicated that intranasal curcumin treatment effectively helped promote diabetic corneal epithelial/nerve wound healing. This novel treatment might be a promising strengthened therapy for diabetic keratopathy.

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confidence: 99%

Intranasal delivery of nanomicelle curcumin promotes corneal epithelial wound healing in streptozotocin-induced diabetic mice

Guo

et al. 2016

Sci Rep

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“…The presence of a response to capsaicin could also be arising from a functional antagonism / interaction between neuropathyevoked reduction of tachykinin release and an increase in smooth muscle sensitivity to these released agents. Alternatively, as has been demonstrated in rat trigeminal ganglia (Troger et al, 1999) and bladder (Santicioli et al, 1987), it seems more likely that the depletion of SP and CGRP in the UUT of STZ-induced diabetic rats was only transient so that sensory nerve function was little altered after 6-8 weeks.…”

Section: Discussionmentioning

confidence: 91%

“…Chronic urine retention and bladder fibrosis can lead to Correspondence to: Dr. Richard J. Lang, Department of Physiology, Monash University, Clayton 3800, Victoria, Australia Phone: +61-3-9905-2517 Fax: +61-3-9905-2547 e-mail: rick.lang@med.monash.edu.au ureterovesical junction obstruction, hydronephrosis and urinary tract infection which if untreated can lead to acute pyelonephritis and corticomedullary abscesses and other kidney pathologies. Both sensory neuropathy (Kamata et al, 1993;Pinna et al, 1994;Troger et al, 1999) and alterations in the physical properties and pharmacological responsiveness of the remodelled detrusor smooth muscle (Santicioli et al, 1987;Kolta et al, 1985) have been postulated to underlie these alterations in bladder function.…”

Section: Introductionmentioning

confidence: 99%

Pelviureteric peristaltic contractions in diabetic rats

Davidson

Lang

2007

J. Smooth Muscle Res.

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The effects of strepozotocin (STZ)-induced diabetes on the spontaneous peristaltic contractions in the upper urinary tract (UUT) of the rat were examined by simultaneously recording the tension in the proximal and distal regions of the renal pelvis and the proximal ureter. All regions of the UUT of diabetic rats contracted at a frequency similar to the contraction frequency of age-matched control rats. In contrast, contraction amplitudes in the proximal and distal renal pelvis and ureter of diabetic rats were 36%, 135% and 121% larger than the equivalent contractions recorded in control rats resulting in a significant increases in the motility index (MI amplitude x frequency) in all 3 regions. Capsaicin (10 µM), substance P (SP 2 µM) and neurokinin A (NKA 2 µM) caused a transient increase in MI in both control and STZ-induced diabetic rats. The rise in basal tension in the proximal and distal renal pelvis evoked by capsaicin, SP or NKA was also significantly greater in the diabetic rats when compared with controls. In contrast, human calcitonin-gene related peptide (hCGRP) produced a relatively small transient inhibition of UUT motility which was little affected by STZ treatment. These results suggest that capsaicin predominantly releases tachykinins from intrinsic sensory nerves in both non-diabetic and STZ-induced diabetic rats. We speculate that the supersensitivity of the diabetic UUT to capsaicin, NKA and SP 8-10 weeks after STZ treatment could be arising from an earlier development of sensory neuropathy.

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“…We cannot exclude the possibility that STZ-induced increase in collagenous tissue in the renal pelvic wall (9) may have impaired the PGE 2 -induced activation of EP4 receptors. Although, the similar baseline renal pelvic release of substance P in sham STZ and STZ rats may argue against the idea that the decreased responsiveness of the renal sensory nerves in STZ rats is due to reduced substance P content, there is evidence in other tissues, e.g., trigeminal ganglion and retina, for substance P content being reduced in STZ rats even before morphological changes are present in peripheral nerves (53,54). The decrease in substance P content in the sciatic nerve in the absence of changes in the expression of lumbar dorsal root ganglia in STZ rats would suggest that the changes in the neuropeptide content are posttranscriptional (7,53,54).…”

Section: Discussionmentioning

confidence: 99%

“…Although, the similar baseline renal pelvic release of substance P in sham STZ and STZ rats may argue against the idea that the decreased responsiveness of the renal sensory nerves in STZ rats is due to reduced substance P content, there is evidence in other tissues, e.g., trigeminal ganglion and retina, for substance P content being reduced in STZ rats even before morphological changes are present in peripheral nerves (53,54). The decrease in substance P content in the sciatic nerve in the absence of changes in the expression of lumbar dorsal root ganglia in STZ rats would suggest that the changes in the neuropeptide content are posttranscriptional (7,53,54). Taken together, we hypothesize that the mechanisms involved in the decreased responsiveness of renal sensory nerves in STZ-induced diabetes are multifactorial and involve activation of the renin angiotensin system and possibly also reduced substance P content, the increased activity of the renin angiotensin system being the dominant mechanism in early stage diabetes type 1.…”

Section: Discussionmentioning

confidence: 99%

Impaired responsiveness of renal sensory nerves in streptozotocin-treated rats and obese Zucker diabetic fatty rats: role of angiotensin

Kopp¹,

Cicha²,

Yorek³

2008

American Journal of Physiology-Regulatory, Integrative and Comp

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Increasing afferent renal nerve activity decreases efferent renal nerve activity and increases urinary sodium excretion. Activation of renal pelvic mechanosensory nerves is impaired in streptozotocin (STZ)-treated rats (model of type 1 diabetes). Decreased activation of renal sensory nerves would lead to increased efferent renal nerve activity, sodium retention, and hypertension. We examined whether the reduced activation of renal sensory nerves in STZ rats was due to increased renal angiotensin activity and whether activation of the renal sensory nerves was impaired in obese Zucker diabetic fatty (ZDF) rats (model of type 2 diabetes). In an isolated renal pelvic wall preparation from rats treated with STZ for 2 wk, PGE2 failed to increase the release of substance P, from 5 ± 1 to 6 ± 1 pg/min. In pelvises from sham STZ rats, PGE2 increased substance P release from 6 ± 1 to 13 ± 2 pg/min. Adding losartan to the incubation bath increased PGE2-mediated release of substance P in STZ rats, from 5 ± 1 to 10 ± 2 pg/min, but had no effect in sham STZ rats. In pelvises from obese ZDF rats (22–46 wk old), PGE2 increased substance P release from 12.0 ± 1.2 to 18.3 ± 1.2 pg/min, which was less than that from lean ZDF rats (10.3 ± 1.6 to 22.5 ± 2.4 pg/min). Losartan had no effect on the PGE2-mediated substance P release in obese or lean ZDF rats. We conclude that the mechanisms involved in the decreased responsiveness of the renal sensory nerves in STZ rats involve activation of the renin angiotensin system in STZ but not in obese ZDF rats.

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The effect of streptozotocin-induced diabetes mellitus on substance P and calcitonin gene-related peptide expression in the rat trigeminal ganglion

Cited by 21 publications

References 41 publications

Intranasal delivery of nanomicelle curcumin promotes corneal epithelial wound healing in streptozotocin-induced diabetic mice

Intranasal delivery of nanomicelle curcumin promotes corneal epithelial wound healing in streptozotocin-induced diabetic mice

Pelviureteric peristaltic contractions in diabetic rats

Impaired responsiveness of renal sensory nerves in streptozotocin-treated rats and obese Zucker diabetic fatty rats: role of angiotensin

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