The Effect of Submucosal Injection of Corticosteroids on Pain Perception and Quality of Life after Root Canal Treatment of Teeth with Irreversible Pulpitis: A Randomized Clinical Trial

Yavari, Hamid Reza; Jafari, Farnaz; Jamloo, Helen; Hallaj‐Nezhadi, Somayeh; Jafari, Sanaz

doi:10.1016/j.joen.2019.01.005

Cited by 23 publications

(35 citation statements)

References 26 publications

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“…Experimental work considers rat successful animal model is for being easily manipulated and a for obtaining similar tissues to the human body 15 and different researches on dexamethasone effect used rats as the model of choice. 2,16 The use of dexamethasone periodontal tissue was studied in different in vitro experiments [17][18] and in vivo available research work dealt with the drug action as repeated injectable doses or as a topical application. 4,19,20 Tooth luxation can be induced by trauma, infection, periodontitis, malocclusion or undue orthodontic force application.…”

Section: Discussionmentioning

confidence: 99%

Effect of Dexamethasone Infiltration on Periodontal Ligament After Experimental Molar Luxation in Rats

Hakam¹

2020

Egyptian Dental Journal

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Aim of the study:Dexamethasone is a popular corticosteroid in dental practice. Submucosal infiltration of dexamethasone proved to be effective to relief post-operative symptoms in different clinical and research application. This study was conducted to evaluate the effect of submucosal dexamethasone single injection on the healing of injured periodontal ligament fibers after molar luxation in rats via histological and gene expression studies. Materials and methods:24Wistar rats were selected for the study. Luxation injuries were performed for all first mandibular molars of both mandibular sides, right & left. Immediately after luxation, the right sides of the mandibles received submucosal injections of dexamethasone sodium phosphate (0.4mg/ml), while left sides were not dexamethasone injected. Follow up periods were 1, 3 & 7 days. Mandibular specimens were studied by routine histology, and quantitative gene expression analysis was done for fibroblast growth factor (FGF2), caspase-3 & alkaline phosphatase (ALP). Results:Histological features revealed superior results of the dexamethasone group with better regeneration and organization of fibers. Gene expression results revealed significant increase in the expression of both FGF2 and alkaline phosphatase (ALP) and a significant decrease in the expression of caspase-3 in the study side when compared to the control side.Conclusion: histologically dexamethasone enhanced the regeneration of torn periodontal ligament fibers with noticeable reduction in inflammation and rise in cellular proliferation. Gene expression reflected the possible benefit of dexamethasone single local injection in the management of periodontal ligament injuries.

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Section: Discussionmentioning

confidence: 99%

Effect of Dexamethasone Infiltration on Periodontal Ligament After Experimental Molar Luxation in Rats

Hakam¹

2020

Egyptian Dental Journal

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“…20 For this it has drawn the attention of research workers on quality of life. 21 Consequently, it has widely been used by the scholars in the field of oral medicine to evaluate the effect of different therapeutic methods on quality of life. 22 A randomized control trial was done in 2012 in which postoperative pain was checked after giving treatment by conventional files and mechanical glide path files.…”

Section: Disscussionmentioning

confidence: 99%

Efficacy of different endodontic procedure with post-operative pain and Quality of Life (QoL) using (OHIP-14).

Abrar

Baig

Maryam

et al. 2021

TPMJ

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To assess efficacy of different Endodontic Procedure with Post-operative Pain and Quality of Life (QoL) using (OHIP-14). Study Design: Longitudinal study. Setting: Dow International Dental College and Dr Ishrat Ul-Ibad Khan Institute Karachi, Pakistan. Period: March 2019 till September 2019. Material & Methods: A convenient sampling was used. Conventional and hand protaper root canal technique were used. Both techniques were separately performed by house officers and Post graduate trainees. Study instrument was a structured questionnaire. There were 3 visits. Patients were recalled after 3 days to ask about the post-operative pain and treatments impact on oral health related quality of life. Data analysis was done using SPSS*20 software. Result: There is a significant association existing between the type of treatment provided to the patient and post-operative pain. Patients who underwent manual protaper RCT felt less pain as compared to those treated with conventional RCT. (p=0.00). Patients who were treated by house officer had experienced more pain (p=0.000) also patients who were treated by house officers take more medication. (p=0.001). Their oral health (OHIP-14) was improved after the endodontic treatment. (P=0.000). Conclusion: Effect of root canal therapy on QoL is apparent in both the groups. Experience level impacts improvement as the postoperative pain complaints were less when treated by postgraduate trainee.

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“…Some clinical assays have been carried out to determine the effect of dexamethasone on the success of dental anesthesia in patients with SIP, and interesting results have been found [ 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 ]. The main aim of this systematic review and meta-analytical assessment was to evaluate the effects of the systemic and local administration of dexamethasone on the anesthetic success rate, pain intensity, and adverse effects in patients with SIP.…”

Section: Introductionmentioning

confidence: 99%

Dexamethasone Increases the Anesthetic Success in Patients with Symptomatic Irreversible Pulpitis: A Meta-Analysis

et al. 2022

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Inferior alveolar nerve block (IANB) has a high failure rate in subjects with symptomatic irreversible pulpitis (SIP). It has been suggested that drugs with anti-inflammatory activity could improve the efficacy of the anesthetic used for IANB. The aim of this study was to assess the effect of dexamethasone on the success of dental anesthesia in patients with SIP. An information search was performed using PubMed and Google Scholar. The risk of bias of the included studies was evaluated with the Cochrane Collaboration’s risk-of-bias tool. The anesthetic success rate, pain intensity (VAS), and adverse effects were extracted. Data were analyzed using the Mantel–Haenszel test and odds ratio or the inverse variance and standardized mean difference. Dexamethasone increased the anesthetic success in comparison with placebo (n = 502; p < 0.001; OR = 2.59; 95% CIs: 1.46 to 4.59). Moreover, patients who were given dexamethasone had lower pain scores at 6 h (n = 302; p < 0.001; MD= −1.43; 95% CIs: −2.28 to −0.58), 12 h (n = 302; p < 0.0001; MD = −1.65; 95% CIs: −2.39 to −0.92), and 24 h (n = 302; p < 0.0008; MD = −1.27; 95% CIs: −2.01 to −0.53) when compared with placebo. In conclusion, the systemic administration of dexamethasone increases the anesthetic success rate and improves pain management in patients with SIP.

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The Effect of Submucosal Injection of Corticosteroids on Pain Perception and Quality of Life after Root Canal Treatment of Teeth with Irreversible Pulpitis: A Randomized Clinical Trial

Cited by 23 publications

References 26 publications

Effect of Dexamethasone Infiltration on Periodontal Ligament After Experimental Molar Luxation in Rats

Effect of Dexamethasone Infiltration on Periodontal Ligament After Experimental Molar Luxation in Rats

Efficacy of different endodontic procedure with post-operative pain and Quality of Life (QoL) using (OHIP-14).

Dexamethasone Increases the Anesthetic Success in Patients with Symptomatic Irreversible Pulpitis: A Meta-Analysis

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