The Effect of Succinylcholine on Intraocular Pressure in Adults, Infants and Children During General Anesthesia

Craythorne, N. W. B.; Rottenstein, H. S.; Dripps, Robert D.

doi:10.1097/00000542-196001000-00011

Cited by 43 publications

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“…Contracture of extraocular muscle is not the only effect of suxamethonium, as section of the muscles does not completely abolish the rise in IOP (Craythorne et al, 1960;Adams and Barnett, 1966). Suxamethonium probably increases the blood flow in the choroid, resulting in raised blood volume and increased IOP (Wahlin, 1960;Adams and Barnett, 1966;Wilson et al, 1974).…”

Section: Discussionmentioning

confidence: 99%

Normocapnic anaesthesia for intraocular surgery.

Adams¹,

Freedman²,

Henville³

1979

British Journal of Ophthalmology

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Section: Discussionmentioning

confidence: 99%

Normocapnic anaesthesia for intraocular surgery.

Adams¹,

Freedman²,

Henville³

1979

British Journal of Ophthalmology

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“…Other substances, such as succinylcholine [29], used as a myorclaxant to facilitate en dotracheal intubation, produce a transitory increase in intraocular pressure up to 18 mm Hg more than the baseline pressure. This tensional response varies according to the type of drug association [30][31][32] and occurs between the 10th and the 40th seconds after intrave nous injection.…”

Section: Ocular Tension Effect O F Anestheticsmentioning

confidence: 99%

Normal Intraocular Pressure in Man

1992

Ophthalmologica

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Whereas the values of 120/70 mm Hg are universally recognized as being normal for the parameter of systemic blood pressure, the value for ‘normal intraocular pressure’ remains very vague. Indeed, values between 7 and 21 mm Hg are often considered normal. However, a careful review of the literature and original data reported here suggest that the intraocular pressure in normal subjects, although dynamic, is a more accurate parameter than is generally expected. The normal value during the day in healthy, young adults is about 12 ± 2 mm Hg, and it increases by 1mm Hg per decade after 40 years of age.

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“…Thus, cerebrospinal fluid pressure-which is considered to vary with changes of the cerebral blood flow (175, 246, 253)-increases temporarily (134) ; the diameter of the conjunctival vessels (135) and the intra-ocular pressure (67,75,153,189,195,259,284) also increase, the latter in consequence of a rise of the intra-ocular blood pressure (194,259) combined with intra-ocular vasodilatation (259). A biphasic reaction of the blood flow in the mesenteric artery of the cat has also been shown to occur with a similar latency (281).…”

Section: A C I R C U L a T O R Y E F F E C T S O F S C Hmentioning

confidence: 99%

Circulatory Effects of Succinylcholine in Man

Gräf

Ström

Wåhlin

1963

Acta Anaesthesiol Scand

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SUMMARY The effects of intravenous (standard apnoeic) and intra‐arterial doses of succinylcholinc chloride (SCh) on peripheral circulation (forearm, hand, skeletal musculature, skin, mucosa of the sigmoid colon), arterial blood pressure and heart rate were studied in 15 unanaesthetized and 17 anaesthetized subjects. Standard apnoeic doses of SCh injected intravenously in anaesthetized subjects produced circulatory changes usually of a biphasic character, a sudden initial decrease in peripheral blood flow and heart rate followed by an increase throughout The apnoeic period; there was also a rise in arterial blood pressure. The initial decrease occurred synchronously with the preparalytic activity of the skeletal musculature (twitchings), but unlike the latter also after repeated injections of SCh. The magnitude of the initial decrease was, on an average, 16 per cent for the peripheral circulation, and 7 per cent for heart rate. The subsequent average increase amounted to 16 per cent above the initial control value for the peripheral circulation, 8 per cent (5 mm Hg) for the systolic, 21 per cent (6 mm Hg) for the diastolic and 9 per cent (4 mm Hg) for the mean arterial blood pressures. Doses of SCh which caused local muscular relaxation on continuous infusion into the brachial artery of unanaesthetized subjects also caused an average blood flow increase in forearm and hand of 43 per cent. This blood flow response remained only during the first few minutes, and then gradually decreased to the control level during the course of the next 10–15 minutes. After the second or third repeated intravenous injection of SCh, but not after further injections, a sudden and marked bradycardia sometimes occurred, with a duration of up to 3 minutes. With repeated intravenous injections of SCh in a standard apnoeic dose, the size and duration of both the circulatory reactions and the duration of the apnoeic period gradually decreased (‘tachyphylaxis’). The individual sensitivity to SCh was rather variable. This was particularly evident in patients with a labile and hyperkinetic circulation (‘vasoregulatory asthenia’) in whom the average blood flow increase during continuous intra‐arterial infusion of SCh was considerably higher than in the control group. The circulatory changes after an intravenous injection of an apnoeic SCh dose should be evaluated in relation to the various interfering factors, such as anaesthesia, atropine premedication, endotracheal intubation, positive‐pressure ventilation, hypoxia, hypercapnia, hypothermia during anaesthesia, and acidosis. The possible mechanisms by which SCh exerts its circulatory effects are discussed, especially the direct effects on the vessels and heart and the indirect effects via nervous or humoral mediators. It is concluded that SCh seems to be a general vasodilator substance. A review of the literature shows that the vasodilator effect of SCh also exists in circulatory areas of the body not directly studied in the present investigation. The vasodilatation is partially caused by a ...

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The Effect of Succinylcholine on Intraocular Pressure in Adults, Infants and Children During General Anesthesia

Cited by 43 publications

References 0 publications

Normocapnic anaesthesia for intraocular surgery.

Normocapnic anaesthesia for intraocular surgery.

Normal Intraocular Pressure in Man

Circulatory Effects of Succinylcholine in Man

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