The Effect of Sun Exposure in Determining Nevus Density in UK Adolescent Twins

Wachsmuth, Rachel C.; Turner, Faye; Barrett, Jennifer; Gaut, Rupert; Randerson-Moor, Juliette; Bishop, D. Timothy; Newton-Bishop, Julia

doi:10.1111/j.0022-202x.2004.23548.x

Cited by 64 publications

(53 citation statements)

References 28 publications

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“…Bauer et al found that German children who wore the most number of clothes at the beach or pool had whole-body nevus counts 24% lower than those who wore the fewest clothes (7). In contrast, a third study of twins in the United Kingdom found no association between nevi on the trunk and wearing shirts while on the beach during a ''hot holiday'' (13).…”

Section: Discussionmentioning

confidence: 85%

“…Australia, with generally high UV radiation, has much higher incidence of melanoma than the United Kingdom, with generally low levels, and children in Australia have more nevi than children in the United Kingdom (14)(15)(16). Two European studies found that wearing clothing during vacations was associated with fewer nevi (7,12), whereas a third found no association (13). In a study of 6-to 7-year-old children, exposure was measured during vacations away from home (12).…”

Section: Discussionmentioning

confidence: 99%

“…The analysis was restricted to nevi on the back because they are common on this site and can be counted with high reliability using slide photographs (11), and assessment of the back's coverage by clothing is relatively simple. Only a few studies have addressed sun protection (as opposed to sun exposure) in relation to nevi (7,12,13), and none has addressed the timing of outdoor activity.…”

Section: Introductionmentioning

confidence: 99%

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Sun Protection and the Development of Melanocytic Nevi in Children

English

Milne

Simpson

2005

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Childhood sun exposure causes nevi (and melanoma), but there is little evidence regarding the effectiveness of sun protection strategies on the number of nevi. We previously found that boys but not girls receiving a school-based sun protection program had fewer nevi on their backs than controls. Here, we investigated whether specific program components (encouraging children to stay indoors in the middle of the day during summer, to wear clothing while outdoors, and to use sunscreen) were associated with fewer nevi. An observational analysis was done on data from a sun protection trial in 1,623 children in Perth, Australia. The outcome was number of nevi on the back 6 years after baseline, when the children were 12 years old. Information on sun protection was obtained by questionnaires 4 and 6 years after baseline. The data were analyzed by mixed-effects linear regression. The time spent outdoors between 11 a.m. and 2 p.m. and the proportion of total time outdoors that was between these hours were positively associated with number of nevi. Ratios of mean counts for doubling the respective measures were 1.09 [95% confidence interval (95% CI), 1.05-1.12] and 1.10 (95% CI, 1.05-1.14). Children whose backs were covered <70% of the time while outdoors had 1.53 (95% CI, 1.34-1.75) times more nevi than children whose backs were always covered. Using sunscreen on the back when it was uncovered was not associated with number of nevi (P = 0.59). Children who stayed indoors in the middle of the day and wore clothing while outdoors had fewer nevi. (Cancer Epidemiol Biomarkers Prev 2005;14(12):2873 -6)

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Section: Discussionmentioning

confidence: 85%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Sun Protection and the Development of Melanocytic Nevi in Children

English

Milne

Simpson

2005

Cancer Epidemiology, Biomarkers &Amp; Prevention

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“…[3][4][5] An alternative hypothesis was that sunscreen use could encourage sun exposures of longer duration, possibly leading to increased risk of melanoma and of BCC. In this article, we review observational and randomized studies that examined sunscreen use and sun exposure duration, according to the sun exposure type associated with sunscreen use.…”

mentioning

confidence: 99%

Sunscreen use and increased duration of intentional sun exposure: Still a burning issue

Autier

Boniol

Doré

2007

Intl Journal of Cancer

195

144

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Sunscreen use is often proposed for sun protection because of their ability to block UV-induced sunburns (the sun protection factor -SPF). Among suntan seekers, however, risk of cutaneous melanoma may be increased because of extended sun exposure duration. We made a systematic review of the evidence linking sunscreen use to sun exposure duration. Five observational studies found that when sun exposure was associated with willingness to get a tan or to stay longer in the sun (i.e., intentional sun exposure), sunscreen use was associated with duration of sun exposure 13-39% longer. Paradoxically, sunburns tend to be more frequent among sunscreen users, probably because of greater natural sun sensitivity. When sun exposure was not intentional, sunscreen use did not increase time spent in the sun. Two European double-blind randomized trials conducted among young sun seekers found daily sun exposure duration, especially sunbathing, 19-25% longer with use of SPF 30 than with use of SPF 10 sunscreens. One randomized trial in a holiday resort in France found a 3-13% increase in sun exposure duration with use of SPF 12 versus SPF 40 sunscreen. But, the SPF 12 groups used 3.6-4.2 more sunscreen than the SPF 40 group, and thus the actual SPF in the SPF 12 group was higher than in the SPF 40 groups. In conclusion, sunscreen use leads to longer duration of sun exposure when sun exposure is intentional, but not when sun exposure is non intentional. ' 2007 Wiley-Liss, Inc.

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“…Some patients present with few lesions, while others have hundreds. Melanocytic naevi develop through childhood and twin studies provide good evidence that naevus number is predominantly genetically determined [3] with a smaller effect of sun exposure [4]. Melanocytic naevi can be broadly divided into congenital and acquired types.…”

Section: Discussionmentioning

confidence: 99%

Classical fusiform excision of melanocytic nevi: our experience

Hassan¹,

Jeelani²,

Keen³

et al. 2013

Our Dermatol Online

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Introduction: Facial melanocytic nevi whether acquired or congenital may pose an aesthetic problem for many patients, especially women. There are many methods of removal of melanocytic nevi including surgical and non-surgical. However, surgical excision by classical fusiform excision remains the most widely used and one of the best methods taking all perspectives into consideration. Aim: To evaluate efficacy of classical fusiform excision for the removal of facial melanocytic nevi. Methods: In a prospective study, 55 facial melanocytic nevi were removed by fusiform excision technique. Incision was given around the nevus in an elliptical pattern, three times as long as it was wide and along the relaxed skin tension lines. Dissection was carried down to midsubcutaneous tissue to remove the nevus down to its full depth. Wound was closed by simple interrupted sutures using 5-0 prolene with adequate undermining of the wound edges. Sutures were removed on 7 th postoperative day. Results: Complete removal of nevi was achieved in all patients with good to excellent cosmetic results. The scar mark if any, would fade in 3-4 months and were imperceptible in 6-9 months. Conclusions: Fusiform excision is one of the best, most widely used and time-tested procedure for complete surgical excision of melanocytic nevi. IntroductionMelanocytic naevi are common lesions that can be found on the integument of almost all individuals. Some patients present with few lesions, while others have hundreds. The number on a given individual increases in rough proportion to the degree of skin pigmentation. Facial melanocytic naevi whether acquired or congenital may pose an aesthetic problem for many patients especially women. There are many methods of removal of melanocytic naevi including surgical and non-surgical. However, surgical excision by classical fusiform excision remains the most widely used and one of the best methods taking into consideration all perspectives. We have found good cosmetic result and complete removal of naevus with no recurrence while removing the facial naevus by means of fusiform excision and here by report our findings.

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The Effect of Sun Exposure in Determining Nevus Density in UK Adolescent Twins

Cited by 64 publications

References 28 publications

Sun Protection and the Development of Melanocytic Nevi in Children

Sun Protection and the Development of Melanocytic Nevi in Children

Sunscreen use and increased duration of intentional sun exposure: Still a burning issue

Classical fusiform excision of melanocytic nevi: our experience

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