The Effect of<sup>131</sup>I on the Aberration-rate of Chromosomes from Chinese Hamster Thyroids

Moore, Wellington; Colvin, M.

doi:10.1080/09553006614550491

Cited by 5 publications

(3 citation statements)

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“…Therefore abnormalities were expected to persist in thyroid cells, which divide infrequently. The results confirm this, and Moore & Colvin (1966) have also described persistent effects of radioactive iodine on the thyroid chromosomes of the Chinese hamster.…”

Section: Discussionsupporting

confidence: 85%

“…Chu (1963) thought that they are probably attributable to the tissue culture conditions, which vary in different laboratories, and to the subjectivity of chromo¬ some analysis. Thyroidal chromosomes of untreated animals have been reported as containing no structural abnormalities (Al-Saadi & Beierwaltes, 1965; Moore & Colvin, 1966). This is surprising in view of previous evidence, but these authors do not state the precautions that were taken to eliminate bias in examining preparations from control and treated animals.…”

Section: Discussionmentioning

confidence: 99%

“…Al-Hindawi & Wilson (1965) also found that irradiation of thyroids with 131I further shortened cellular lifespan, as would be expected since radiation alone may diminish survival. 131I presumably caused direct chromosome damage and this has been demonstrated in the thyroid of Chinese hamsters (Moore & Colvin, 1966). Abnormalities of rat thyroid chromosomes have been reported to follow goitrogenesis caused by iodine deprivation for periods greater than one month (Al-Saadi & Beierwaltes, 1965).…”

Section: Introductionmentioning

confidence: 93%

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The Effect of Propylthiouracil and 131i on Rat Thyroid Chromosomes

Speight¹,

Baba²,

Wilson³

1968

Journal of Endocrinology

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SUMMARY Rat chromosomes prepared from thyroid cells grown in culture did not differ from those described for other tissues of this species. The incidence of thyroid cells with abnormal chromosomes was not increased by giving propylthiouracil to rats for 15 weeks. The thyroid chromosomes were damaged by injection of 1–25 μc of 131I. The damage persisted in the unstimulated thyroid for 15 weeks. Administration of propylthiouracil to rats after 131I caused significant reduction in the frequency of thyroid cells with radiation-damaged chromosomes.