1982
DOI: 10.1016/0014-5793(82)80932-0
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The effect of superoxide generation on the ability of mitochondria to take up and retain Ca2+

Abstract: When heart or liver mitochondria are exposed to superoxide radicals generated from xanthine + xanthine oxidase their ability to take up and to retain Ca 2+ is impaired. The rate of oxidation of pyruvate + malate as substrates is diminished and the appearance of thiol groups when the mitochondria are supplied with these substrates is abolished. These inhibitory effects are offset if respiration is supported by succinate in presence of rotenone provided that a substrate (fl-hydroxybutyrate) is provided to mainta… Show more

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Cited by 66 publications
(17 citation statements)
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“…The time course of these effects varied depending on the free radical-generating system used, probably as a result of different rates of production of free radical species with the different systems. (6,(39)(40)(41)(42). In the septum, the transient increase followed by a decrease in developed tension and rise in rest tension are consistent with a progressive rise in cytosolic calcium.…”
Section: Resultsmentioning
confidence: 60%
“…The time course of these effects varied depending on the free radical-generating system used, probably as a result of different rates of production of free radical species with the different systems. (6,(39)(40)(41)(42). In the septum, the transient increase followed by a decrease in developed tension and rise in rest tension are consistent with a progressive rise in cytosolic calcium.…”
Section: Resultsmentioning
confidence: 60%
“…Exogenous free radicals would be expected to enhance cellular calcium loading by the known inhibition ofNa'-K+ ATPase in the surface membrane and of Ca2+-ATPase in both the sarcolemma and the sarcoplasmic reticulum (20,22,23,(62)(63)(64)(65). Free radicals are also capable ofinjuring mitochondrial Ca2+-ATPase (34). These various effects may be direct consequences of the oxidant species, or they may be mediated through end products oflipid peroxidation which could in turn react with integral membrane proteins.…”
Section: Discussionmentioning
confidence: 99%
“…These various effects may be direct consequences of the oxidant species, or they may be mediated through end products oflipid peroxidation which could in turn react with integral membrane proteins. Disruption ofcell integrity has been argued not to be necessary (17,34 (9,17,24,68). During ischemia, it has been proposed that glucose produces ATP in proximity to the sarcolemma at a critical rate to maintain calcium homeostasis, thus delaying calcium overload (24 (33).…”
Section: Discussionmentioning
confidence: 99%
“…Since antipyrylazo III does not elicit such side reactions, its use should be preferred. In addition, experiments in which the effect of xanthine-xanthine oxidase on Ca2+ transport by intact mitochondria was measured by changes in arsenazo III absorbance [22] should be re-evaluated in view of the reduction of this dye by that system.…”
Section: Discussionmentioning
confidence: 99%