The chapter explores the broad implications of automation and artificial intelligence (AI) on e-commerce logistics. It discusses how these technologies are altering supply chains through automated warehousing, order processing, and artificial intelligence-driven demand forecasting and personalization. Despite their transformational potential, the chapter highlights issues such as data security, integration, workforce adaptation, and ethical considerations. It also includes real-world case studies demonstrating the successes of businesses that have embraced automation and artificial intelligence, as well as glimpses into the future of e-commerce logistics, stressing emerging technology and projected trends. Finally, the chapter serves as a comprehensive guide for businesses wishing to harness the potential of automation and artificial intelligence in the ever-changing world of e-commerce logistics.