The effect of surface modification of dendronized gold nanoparticles on activation and release of pyroptosis-inducing pro-inflammatory cytokines in presence of bacterial lipopolysaccharide in monocytes

Kuc-Ciepluch, Dorota; Gorzkiewicz, Micha; Pedziwiatr-Werbicka, Elzbieta; Barrios-Gumiel, Andrea; Lasak, Magdalena; Mariak, Aleksandra; Sztandera, Krzysztof; Gómez, Rafael; Mata, F. Javier de la; Lankoff, Anna; Klajnert‐Maculewicz, Barbara; Bryszewska, Maria; Arabski, Michał; Ciepluch, Karol

doi:10.1016/j.colsurfb.2022.112652

Cited by 3 publications

(2 citation statements)

References 39 publications

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“…In a Polish–German–Spanish study [ 88 ], the researchers aimed to investigate the induction of pyroptosis, an inflammatory form of programmed cell death, in immune cells, particularly macrophages, by combining dendronized AuNPs with bacterial lipopolysaccharides (LPSs) known for their pro-inflammatory properties. The results demonstrated that the decorated AuNPs promoted caspase-1 activity (3–4 times higher than the control) and enhanced the release of interleukin (IL)-18 and IL-1β, which are pro-inflammatory cytokines.…”

Section: Covalent Dendrimers Self-assembling Dendrimers and Dendrimer...mentioning

confidence: 99%

The Spicy Science of Dendrimers in the Realm of Cancer Nanomedicine: A Report from the COST Action CA17140 Nano2Clinic

Pricl

2023

Pharmaceutics

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COST Action CA17140 Cancer Nanomedicine—from the bench to the bedside (Nano2Clinic,) is the first, pan-European interdisciplinary network of representatives from academic institutions and small and medium enterprises including clinical research organizations (CROs) devoted to the development of nanosystems carrying anticancer drugs from their initial design, preclinical testing of efficacy, pharmacokinetics and toxicity to the preparation of detailed protocols needed for the first phase of their clinical studies. By promoting scientific exchanges, technological implementation, and innovative solutions, the action aims at providing a timely instrument to rationalize and focus research efforts at the European level in dealing with the grand challenge of nanomedicine translation in cancer, one of the major and societal-burdening human pathologies. Within CA17140, dendrimers in all their forms (from covalent to self-assembling dendrons) play a vital role as powerful nanotheranostic agents in oncology; therefore, the purpose of this review work is to gather and summarize the major results in the field stemming from collaborative efforts in the framework of the European Nano2Clinic COST Action.

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Section: Covalent Dendrimers Self-assembling Dendrimers and Dendrimer...mentioning

confidence: 99%

The Spicy Science of Dendrimers in the Realm of Cancer Nanomedicine: A Report from the COST Action CA17140 Nano2Clinic

Pricl

2023

Pharmaceutics

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“…A wide range of potential applications for dendritic structures have been proposed based on the unique molecular symmetry structures and multitude of outstanding properties. − Poly-amidoamine (PAMAM) has the advantages such as a highly branched molecular structure, a high functional groups density, a controllable molecular size, etc. Based on these advantages, the PAMAM dendrimer has been extended to various fields including carriers, membrane materials, flocculants, and so forth. − Although the PAMAM dendrimer exhibits a profound impact in numerous fields, its utilization as a flame retardant has been rarely reported.…”

Section: Introductionmentioning

confidence: 99%

Poly(amidoamine) Dendrimers: An Excellent Intrinsic Flame Retardant and Curing Agent for Epoxy Resins

Yang

et al. 2023

ACS Appl. Polym. Mater.

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Considerable efforts have been made to fabricate the intrinsic epoxy resin (EP) with excellent flame retardancy and mechanical properties. However, conventional single molecule flame retardants have met the bottleneck after the massive research studies of the past decade, and with the development of the polymer technology, dendritic flame retardants have been studied due to their versatility and more efficient flame retardancy. Herein, poly-amidoamine (PAMAM) dendrimer flame retardants of different generations were synthesized and utilized as a curing agent and a flame retardant to fabricate the intrinsic EP materials. Their impacts on integrated properties of an EP matrix were studied thoroughly. As expected, the thermal stability, the fire safety, and the flexural capacity of EP/PAMAM thermosets were highly strengthened. The results showed that with 20 wt % loading content of the third-generation PAMAM(G3) dendrimer in the EP matrix (named as EP/20G3), its limited oxygen index value reached up to 26.4% and passed the UL-94 V-0 level. The peak heat release rate and the total heat release data decreased by 51.1 and 60.3%, respectively. Furthermore, the values of T g , flexural strength, and flexural modulus of EP/20G3 were also promoted comparing with that of the pure EP. At the same time, as an amino-abundant compound, PAMAM dendrimers with different generations can also be served as a curing agent for EP instead of the commonly used diethylenetriamine. It means that PAMAM dendrimers play a dual role in the preparation of flame retardant EP in this system.

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Cellular uptake of rose bengal is mediated by OATP1B1/1B3 transporters

Sztandera

Gorzkiewicz

Zizzi

et al. 2023

Bioelectrochemistry

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The effect of surface modification of dendronized gold nanoparticles on activation and release of pyroptosis-inducing pro-inflammatory cytokines in presence of bacterial lipopolysaccharide in monocytes

Cited by 3 publications

References 39 publications

The Spicy Science of Dendrimers in the Realm of Cancer Nanomedicine: A Report from the COST Action CA17140 Nano2Clinic

The Spicy Science of Dendrimers in the Realm of Cancer Nanomedicine: A Report from the COST Action CA17140 Nano2Clinic

Poly(amidoamine) Dendrimers: An Excellent Intrinsic Flame Retardant and Curing Agent for Epoxy Resins

Cellular uptake of rose bengal is mediated by OATP1B1/1B3 transporters

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