The effect of surface poly(ethylene glycol) length on in vivo drug delivery behaviors of polymeric nanoparticles

Wang, Jilong; Du, Xiao-Jiao; Yang, Jinxian; Shen, Song; Li, Hongjun; Luo, Ying-Li; Iqbal, Shoaib; Xu, Cong; Ye, Xiaodong; Cao, Jie; Wang, Jun

doi:10.1016/j.biomaterials.2018.08.022

Cited by 84 publications

(55 citation statements)

References 44 publications

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“…Proper modification of GO, using polymers, noble-metal nanoparticles and molecules, improves its fluorescence emission for definite detection/biosensing purposes 41,42 . For targeting delivery purposes, the modification with polymers increases the hydrophilicity and circulation of GO through the biological environment and reduces the steric hindrance between the targeting ligand and biomarker 43,44 . There are some reports on several polymers, including polyethyleneimine-polylactide (PEI-PLA) and polyethylene glycol (PEG), with bright and multi-color auto-fluorescence properties for theranostic systems 45,46 .…”

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confidence: 99%

Graphene oxide and its derivatives as promising In-vitro bio-imaging platforms

Esmaeili

Bidram

Zarrabi

et al. 2020

Sci Rep

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Intrinsic fluorescence and versatile optical properties of Graphene Oxide (GO) in visible and near-infrared range introduce this nanomaterial as a promising candidate for numerous clinical applications for early-diagnose of diseases. Despite recent progresses in the impact of major features of GO on the photoluminescence properties of GO, their modifications have not yet systematically understood. Here, to study the modification effects on the fluorescence behavior, poly ethylene glycol (PEG) polymer, metal nanoparticles (Au and Fe3O4) and folic acid (FA) molecules were used to functionalize the GO surface. The fluorescence performances in different environments (water, DMEM cell media and phosphate buffer with two different pH values) were assessed through fluorescence spectroscopy and fluorescent microscopy, while Fourier-transform infrared spectroscopy (FTIR) and X-ray diffraction (XRD) and Scanning electron microscopy (SEM) were utilized to evaluate the modifications of chemical structures. The modification of GO with desired molecules improved the photoluminescence property. The synthesized platforms of GO-PEG, GO-PEG-Au, GO-PEG-Fe3O4 and GO-PEG-FA illustrated emissions in three main fluorescence regions (blue, green and red), suitable for tracing and bio-imaging purposes. Considering MTT results, these platforms potentially positioned themselves as non-invasive optical sensors for the diagnosis alternatives of traditional imaging agents.

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mentioning

confidence: 99%

Graphene oxide and its derivatives as promising In-vitro bio-imaging platforms

Esmaeili

Bidram

Zarrabi

et al. 2020

Sci Rep

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“…Some polymers can escape from the identification of the immune system and thereby extending circulation time. 39 In addition, in order to avoid accelerated blood clearance, 40 many efforts have been made to produce biomimetic systems suitable for drug delivery in vivo, such as cell membrane coating technology. 41 However, certain coating materials could be toxic, which limits their applications in the biomedical field.…”

Section: Coatingmentioning

confidence: 99%

Superparamagnetic Iron Oxide Nanoparticles: Cytotoxicity, Metabolism, and Cellular Behavior in Biomedicine Applications

Wu¹,

Hu²,

Wang³

et al. 2021

IJN

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Superparamagnetic iron oxide nanoparticles (SPIONs) have been widely investigated and applied in the field of biomedicine due to their excellent superparamagnetic properties and reliable traceability. However, with the optimization of core composition, shell types and transfection agents, the cytotoxicity and metabolism of different SPIONs have great differences, and the labeled cells also show different cellular behaviors. Therefore, a holistic review of the construction and application of SPIONs is desired. This review focuses the advances of SPIONs in the field of biomedicine in recent years. After summarizing the toxicity of different SPIONs, the uptake, distribution and metabolism of SPIONs in vitro were discussed. Then, the regulation of labeled-cells behavior is outlined. Furthermore, the major challenges in the optimization process of SPIONs and insights on its future developments are proposed.

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“…Two primary obstacles may explain this discrepancy between scientific and clinical findings: (1) the ability of organisms to recognize and remove foreign substances via NP uptake by the reticuloendothelial system (RES), and (2) a complex circulatory environment with high levels of proteins and circulating immune cells in vivo, leading to interactions that further promote NP clearance [11]. Poly(ethylene glycol) (PEG) has been extensively employed as the gold standard means of modifying NP surfaces, allowing for a reduction in NP recognition by the immune system and thereby extending circulation time [12]. The PEGylated polymers used for coating NPs are able to create a hydration layer, which is known to markedly reduce rates of nonspecific interactions in the bloodstream and to suppress RES uptake, thus increasing NP uptake time in vivo from minutes (for uncoated particles) to hours (for PEG-coated particles) [13,14].…”

Section: Introductionmentioning

confidence: 99%

“…Poly(ethylene glycol) (PEG) has been extensively employed as the gold standard means of modifying NP surfaces, allowing for a reduction in NP recognition by the immune system and thereby extending circulation time [ 12 ]. The PEGylated polymers used for coating NPs are able to create a hydration layer, which is known to markedly reduce rates of nonspecific interactions in the bloodstream and to suppress RES uptake, thus increasing NP uptake time in vivo from minutes (for uncoated particles) to hours (for PEG-coated particles) [ 13 , 14 ].…”

Section: Introductionmentioning

confidence: 99%

Cell Membrane Coating Technology: A Promising Strategy for Biomedical Applications

et al. 2019

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Cell membrane coating technology is an approach to the biomimetic replication of cell membrane properties, and is an active area of ongoing research readily applicable to nanoscale biomedicine. Nanoparticles (NPs) coated with cell membranes offer an opportunity to unite natural cell membrane properties with those of the artificial inner core material. The coated NPs not only increase their biocompatibility but also achieve effective and extended circulation in vivo, allowing for the execution of targeted functions. Although cell membrane-coated NPs offer clear advantages, much work remains before they can be applied in clinical practice. In this review, we first provide a comprehensive overview of the theory of cell membrane coating technology, followed by a summary of the existing preparation and characterization techniques. Next, we focus on the functions and applications of various cell membrane types. In addition, we collate model drugs used in cell membrane coating technology, and review the patent applications related to this technology from the past 10 years. Finally, we survey future challenges and trends pertaining to this technology in an effort to provide a comprehensive overview of the future development of cell membrane coating technology.

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The effect of surface poly(ethylene glycol) length on in vivo drug delivery behaviors of polymeric nanoparticles

Cited by 84 publications

References 44 publications

Graphene oxide and its derivatives as promising In-vitro bio-imaging platforms

Graphene oxide and its derivatives as promising In-vitro bio-imaging platforms

Superparamagnetic Iron Oxide Nanoparticles: Cytotoxicity, Metabolism, and Cellular Behavior in Biomedicine Applications

Cell Membrane Coating Technology: A Promising Strategy for Biomedical Applications

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