The effect of surgery and radiotherapy on outcome of anaplastic thyroid carcinoma

Pierie, Jean-Pierre E. N.; Muzikansky, Alona; Gaz, Randall D.; Faquin, William C.; Ott, Mark J.

doi:10.1245/aso.2002.9.1.57

Cited by 177 publications

(142 citation statements)

References 16 publications

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“…Surgical excision is rarely feasible and ATC is the least radiosensitive among all thyroid tumors and is nonresponsive to I-131 therapy (14,15). Chemotherapy is used if the tumor has characteristics of no response to I-131, nonoperability, and no effect to external radiotherapy.…”

Section: Discussionmentioning

confidence: 99%

Efficacy on anaplastic thyroid carcinoma of valproic acid alone or in combination with doxorubicin, a synthetic chenodeoxycholic acid derivative, or lactacystin

Kim

Yoo²,

Kang³

et al. 2009

Int J Oncol

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Abstract. The present study investigated the mechanism underlying the antitumor activity of the histone deacetylases inhibitor valproic acid (VPA), alone and in combination with doxorubicin, a synthetic chenodeoxycholic acid derivative (HS-1200), or the proteasome inhibitor lactacystin on cultured anaplastic thyroid carcinoma KAT-18 cells. Cell viability was evaluated by trypan-blue exclusion. Western blotting determined caspase and histone deacetylase activities and expression of poly(ADP)-ribose polymerase. Induction of apoptosis was identified by Hoechst staining, DNA electrophoresis, DNA hypoploidy and cell cycle phase analysis, and measurement of mitochondrial membrane potential. Subcellular translocation of apoptosis inducing factor and caspase-activated DNase after treatment was determined by confocal microscopy following immunofluorescent staining. VPA treatment increased apoptotic death of KAT-18 cells. VPA treatment was also associated with degradation of procaspase-3, procaspase-7, and poly(ADP)-ribose polymerase; induction of histone hyperacetylation; condensation of peripheral chromatin; decreased mitochondrial membrane potential and DNA content; and decreased translocation of apoptosis inducing factor and caspase-activated DNase. VPA in combination with doxorubicin, HS-1200, or lactacystin, applied at the highest concentrations that did not induce KAT-18 cell death, efficiently induced apoptosis in KAT-18 cells. The results suggest VPA combination therapy may represent an alternative therapeutic strategy for anaplastic thyroid carcinoma.

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Section: Discussionmentioning

confidence: 99%

Efficacy on anaplastic thyroid carcinoma of valproic acid alone or in combination with doxorubicin, a synthetic chenodeoxycholic acid derivative, or lactacystin

Kim

Yoo²,

Kang³

et al. 2009

Int J Oncol

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“…In accordance, we demonstrated that surgery significantly improved survival (p=0.034) only by univariate analysis. Pierie et al treated 44 out of 67 ATC patients surgically and reported 1 and 3 year OS rates of 92% and 83%, respectively after complete resection; 35% and 0%, respectively, after debulking; and 4% and 0%, respectively, after no resection 35 . In the current study surgery was carried out in 46.7% of the patients whether as single treatment or combined with other modality.…”

Section: Discussionmentioning

confidence: 99%

Treatment Outcome and Prognostic Factors of Anaplastic Thyroid Carcinoma: A Single Institution Experience in Egypt

Ibrahim

Askoura

2018

Kasr-Al-Aini J.of Clin. Onc. and Nuc. Med.

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Introduction: Anaplastic thyroid carcinoma (ATC) is a rare lethal malignancy. It is one of the most aggressive human malignancies with limited progress in finding effective therapies. Aim: We aimed to study the treatment outcome and prognostic factors of ATC patients treated at our institution. Methods: We retrospectively analyzed charts of 30 ATC patients, treated at the Clinical Oncology Department, AinShams University from 2006 to 2017. The clinical characteristics and factors affecting survival were studied. Kaplan-Meier survival curve was used to analyze the overall survival (OS) of the patients. Results: The median age of patients was 60 years and males represented 63% of them. Almost half of patients (47%) had stage IVA disease. Equal number of patients received combined modality treatment versus single modality treatment (37% each). The median OS was 3 months (95% Confidence interval: 1.429-4.571). Variables associated with significantly better OS in univariate analysis included male sex (p=0.04), stage IVA disease (p=0.012), surgical treatment (p=0.034), radiotherapy (p=0.003), and combined modality treatment (p=0.005). However, only female sex was identified as significant poor prognostic variable of OS (p=0.043) by multivariate analysis. Conclusion: Our results of treatment outcome and prognosis of ATC agree with most of the literature. Multimodality treatment is currently the standard of care. While still there is no successful treatment of this rapidly fatal disease, exploration of novel therapies and approaches are warranted to help improve the outcome.

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“…One-year survival was almost doubled with fosbretabulin, when compared to chemotherapy alone (23% versus 9%). OS was objectively longer in patients less than 60 years of age, increasing from a median of 3.1 months to 10.9 months (HR of 0.38, 95% CI: 0.16, 0.88) [46][47][48][49][50].…”

Section: Emerging Therapiesmentioning

confidence: 98%

Rapid Recurrence of Anaplastic Carcinoma: Advocacy towards Non-Surgery

Habra¹

2017

EMIJ

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DiscussionThe majority of anaplastic cancers are revealed by the rapid transformation of an old goitre: increase in volume, pain, dysphonia, dyspnea by tracheal compression and dysphagia thereafter. The nodal invasions, the repercussion on the general state, immediately sign the gravity of the situation. The cervical ultrasound is not specific but allows suspecting a malignant AbstractAnaplastic carcinoma of the thyroid (ATC) is a rare but aggressive tumor, its prognosis is dark. Most patients diagnosed with this disease are 65 years of age or older, treatment is based on the combined action of radiotherapy, chemotherapy and surgical removal when possible. We report a case of anaplastic carcinoma of the thyroid which has been thundering in postoperative surgery after total thyroidectomy, this case highlights the ineffectiveness of surgery in the reduction of tumor mass. Surely contribute to a historical recurrence and aggravate the prognosis. We will study through a review of the literature the clinical aspects and discuss the therapeutic modalities of this cancer.Keywords: Anaplastic thyroid carcinoma; Therapeutic modalities

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The effect of surgery and radiotherapy on outcome of anaplastic thyroid carcinoma

Abstract: Candidates for surgery with curative intent for ATC are patients < or = 70 years, tumors < or = 5 cm, and no distant disease. Radiotherapy >45 Gy improves outcome.

Cited by 177 publications

References 16 publications

Efficacy on anaplastic thyroid carcinoma of valproic acid alone or in combination with doxorubicin, a synthetic chenodeoxycholic acid derivative, or lactacystin

Efficacy on anaplastic thyroid carcinoma of valproic acid alone or in combination with doxorubicin, a synthetic chenodeoxycholic acid derivative, or lactacystin

Treatment Outcome and Prognostic Factors of Anaplastic Thyroid Carcinoma: A Single Institution Experience in Egypt

Rapid Recurrence of Anaplastic Carcinoma: Advocacy towards Non-Surgery

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