The Effect of Surgical Treatment for Secundum Atrial Septal Defect in Patients More Than 30 Years Old

Erkut, Bilgehan; Becit, Necip; Ünlü, Yahya; Ceviz, Münacettin; Koçoğulları, Cevdet Uğur; Ateş, Azman; Karapolat, Bekir Sami; Kayğın, Mehmet Ali; Koçak, Hikmet

doi:10.1532/hsf98.20071059

Cited by 3 publications

(1 citation statement)

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“…This table also shows the ‘quality score’ assigned, based on the number of factors matched. Ten studies matched ≥4 factors scoring 3 points for quality 13 16 17 20 21 23 25 27 34 35. In this group the OR for prevalence of post-closure AT was 0.70 (95% 0.51 to 0.97).…”

Section: Resultsmentioning

confidence: 99%

Atrial septal defect closure is associated with a reduced prevalence of atrial tachyarrhythmia in the short to medium term: a systematic review and meta-analysis

Vecht

Saso

Rao

et al. 2010

Heart

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Atrial tachyarrhythmias are a common complication of atrial septal defects. The objective was to determine the effect of atrial septal defect closure on pre-existing atrial tachyarrhythmias and to investigate if such an effect is present after either surgical or percutaneous closure. Medline, EMBASE, Cochrane Library, and Google Scholar databases were searched between 1967 and 2009. The search was expanded using the 'related articles' function and reference lists of key studies. All studies reporting pre- and post- closure incidence (or prevalence) of atrial tachyarrhythmias in the same patient groups were included. Data were independently extracted by two authors according to a pre-defined protocol. Incongruities were settled by consensus decision. Twenty six studies were identified including 1841 patients who underwent surgical closure and 945 who underwent percutaneous closure. Meta-analysis using a random effects model demonstrated a reduction in the prevalence of atrial tachyarrhythmias following atrial septal defect closure [OR = 0.66 (95% CI 0.57-0.77)]. This effect was demonstrated after both percutaneous [OR = 0.49 (95% CI 0.32-0.76)] and surgical closure [OR = 0.72 (95% CI 0.60-0.87)]. Immediate (<30 days) and mid-term (30 days - 5 years) follow-up also demonstrated a reduction in AT prevalence [ORs of 0.80 (95% CI 0.66-0.97) and 0.47 (95% CI 0.36-0.62) respectively]. Atrial septal defect closure, whether surgical or percutaneous, is associated with a reduction in the post-closure prevalence of pre-existing atrial tachyarrhythmias and atrial fibrillation in the short to medium term.

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