The Effect of Susceptibility of Gadolinium Contrast Media on Diffusion-weighted Imaging and the Apparent Diffusion Coefficient

Ogura, Akio; Hayakawa, Katsumi; Miyati, Tosiaki; Maeda, Fumie

doi:10.1016/j.acra.2007.12.020

Cited by 25 publications

(25 citation statements)

References 16 publications

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“…DW imaging was performed approximately 10 minutes after injection of a gadolinium-based contrast agent during the dynamic contrast-enhanced MR imaging study. While several studies reported negligible effects of contrast agent on ADC measurements (14,(55)(56)(57), there have been conflicting reports on this topic (58,59), and this factor should also be considered when comparing our results with other studies.…”

Section: Intra-and Interobserver Variabilitymentioning

confidence: 47%

Nonmalignant Breast Lesions: ADCs of Benign and High-Risk Subtypes Assessed as False-Positive at Dynamic Enhanced MR Imaging

Parsian¹,

Rahbar²,

Allison³

et al. 2012

Radiology

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Purpose:To evaluate the diffusion-weighted (DW) imaging characteristics of nonmalignant lesion subtypes assessed as false-positive findings at conventional breast magnetic resonance (MR) imaging. Materials and Methods:This HIPAA-compliant retrospective study had institutional review board approval, and the need for informed patient consent was waived. Lesions assessed as Breast Imaging Reporting and Data System category 4 or 5 at clinical dynamic contrast material-enhanced MR imaging that subsequently proved nonmalignant at biopsy were retrospectively reviewed. One hundred seventy-five nonmalignant breast lesions in 165 women were evaluated. Apparent diffusion coefficients (ADCs) from DW imaging (b = 0, 600 sec/mm 2 ) were calculated for each lesion and were compared between subtypes and with an ADC threshold of 1.81 3 10 23 mm 2 /sec (determined in a prior study to achieve 100% sensitivity). Results:Eighty-one (46%) lesions exhibited ADCs greater than the predetermined threshold. /sec; n = 23) was the most common lesion subtype with ADC below the threshold. Lymph nodes exhibited the lowest mean ADC of all nonmalignant lesions ([1.28 6 0.23] 3 10 23 mm 2 /sec; n = 4). High-risk lesions (atypical ductal hyperplasia and lobular neoplasia) showed significantly lower ADCs than other benign lesions (P , .0001) and were the most common lesions with ADCs below the threshold. Conclusion:Assessing ADC along with dynamic contrast-enhanced MR imaging features may decrease the number of avoidable false-positive findings at breast MR imaging and reduce the number of preventable biopsies.

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Section: Intra-and Interobserver Variabilitymentioning

confidence: 47%

Nonmalignant Breast Lesions: ADCs of Benign and High-Risk Subtypes Assessed as False-Positive at Dynamic Enhanced MR Imaging

Parsian¹,

Rahbar²,

Allison³

et al. 2012

Radiology

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“…Most studies have shown that there was not a statistically significant effect of contrast material on the ADC values. 20,21 However, another study published by Firat et al 22 has shown that contrast medium injection had significant and time-dependent effects on ADC values. According to these findings, they have offered the use of DWI only before or late after contrast material injection for quantitative ADC studies.…”

Section: Discussionmentioning

confidence: 96%

Diffusion-Weighted Imaging of the Rectosigmoid Colon

Kılıçkesmez

Atilla²,

Soylu³

et al. 2009

Journal of Computer Assisted Tomography

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“…Detection of a malignant tumour is based on the increase in signal intensity on DWI, and discrimination between benign and malignant tumours is based on the apparent diffusion coefficient (ADC). However, several factors may alter the ADC (7)(8)(9)(10)(11). Iodinated contrast agents are predicted to affect the ADC due to their high viscosity and large molecular size.…”

Section: Introductionmentioning

confidence: 99%

Effects of Iodinated Contrast Agent on Diffusion Weighted Magnetic Resonance Imaging

et al. 2009

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Purpose: To evaluate the effects of iodine contrast agent on diffusion signal intensity and apparent diffusion coefficient (ADC) in diffusion-weighted imaging (DWI) studies in MRI examination just after computed tomography (CT) contrast imaging. Methods:On a 1.5 T MRI scanner, ADC was calculated from the signal intensity of DWI (b = 0 and 1000) using phantoms filled with contrast agent (0, 4.5, 6.0, 9.0, 30, and 60 mg I/mL). We evaluated the signal intensities of DWI and ADC in 10 patients (3 women, 7 men, 35-68 years old) examined by MRI study less than 40 minutes after injection of 100 mL of iopamidol (300 mg I/mL) for CT study. Results:The DWI signal increased until a CT value of 190 HU, but showed no changes above this value. The ADC decreased with increases in CT value. Less than 40 minutes after injection of iopamidol (300 mg I/mL) for CT scan, the signal intensity of DWI was significantly increased and ADC was significantly decreased.1 Conclusion: It is necessary to recognise the rate of decrease of ADC, because it is dependent on the density of iodine contrast agents.2

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The Effect of Susceptibility of Gadolinium Contrast Media on Diffusion-weighted Imaging and the Apparent Diffusion Coefficient

Cited by 25 publications

References 16 publications

Nonmalignant Breast Lesions: ADCs of Benign and High-Risk Subtypes Assessed as False-Positive at Dynamic Enhanced MR Imaging

Nonmalignant Breast Lesions: ADCs of Benign and High-Risk Subtypes Assessed as False-Positive at Dynamic Enhanced MR Imaging

Diffusion-Weighted Imaging of the Rectosigmoid Colon

Effects of Iodinated Contrast Agent on Diffusion Weighted Magnetic Resonance Imaging

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