The effect of sympathetic blockade or hyperventilation on epinephrine-induced cardiac arrhythmias during anaesthesia with halothane and methoxyflurane

Israel, Jacob S.; Dobkin, Allen B.; Robidoux, Henry J.

doi:10.1007/bf03021254

Cited by 6 publications

(2 citation statements)

References 8 publications

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“…It may well be that the ability of the former agent to sensitize the human heart to adrenaline is less than that of halothane. It has been shown by Israel, Dobkin and Robidoux (1962) that, in the dog, adrenaline-induced arrhythmias are less severe during methoxyflurane anaesthesia than when halothane is inhaled. Such considerations are in keeping with the clinical impression that although respiratory depression is a feature of methoxyflurane anaesthesia, disorders of cardiac rhythm rarely occur.…”

Section: Discussionmentioning

confidence: 99%

Effects of Methoxyflurane (Penthrane) Anaesthesia in Children

Black¹,

Rea²

1964

British Journal of Anaesthesia

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Some circulatory and respiratory effects of methoxyflurane anaesthesia were studied in ten normal children. Arterial pressure was little altered by this anaesthetic and the changes observed resembled those produced by halothane rather than di-ethyl ether. The degree of respiratory depression during methoxyflurane anaesthesia was intensified by increasing the concentration of the inhaled vapour. There was no tendency to hyperglycaemia, either prior to or during surgery. Ventricular irregularities were not a feature of methoxyflurane anaesthesia, at either normal or elevated end tidal Pco 2 levels.

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Section: Discussionmentioning

confidence: 99%

Effects of Methoxyflurane (Penthrane) Anaesthesia in Children

Black¹,

Rea²

1964

British Journal of Anaesthesia

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“…Previous studies of the effect of methoxyflurane on sensitivity of the heart to epinephrine-induced ventricular arrhythmias have been concerned either with comparisons made between the effect of methoxyflurane and the effect of other inhalation anaesthetics, 1.4-~ or with the effect of methoxyflurane on the response to single intravenous injections of epinephrine2 , 18 The former studies give important comparative data but do not define the effect of methoxyflurane per se. The latter by relying upon the single injection of a standard amount of epinephrine make the determination of sensitivity thresholds in individual animals impossible because the amount of epinephrine injected may be in excess of the minimum amount required to produce an arrhythmic effect.…”

Section: Dlsctlsslonmentioning

confidence: 99%

Effect of methoxyflurane on epinephrine-induced ventricular arrhythmias

Burleigh¹,

Greene

1970

Can. Anaesth. Soc. J.

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THE EFFECT OF METHOXYFLURANE on the sensitivity of the heart to epinephrineinduced ventricular arrhythmias has not been clearly defined. On the one hand, animal experiments have been reported which found that methoxyflurane increases ventricular arrhythmias associated with epinephrine administration. 1,~ On the other hand, other studies have found that methoxyflurane protects against arrhythmias? ,4 Still other reports have found methoxyflurane to be less sensitizing than cyclopropane or halothane, but as sensitizing as chloroform or halothaneether azeotrope. 5,6 That epinephrine can be safely injected subcutaneously to secure haemostatis during operations performed under methoxyflurane 7-15 is a unanimous ff pragmatic observation. It is an observation, however, which neither defines the risk, ff any, involved in such a practice, nor contributes to our understanding of the pharmacological properties of methoxyflurane.The present study was undertaken to evaluate under controlled conditions in experimental animals (1) the effect of methoxyflurane on ventricular sensitivity to epinephrine-induced arrhythmias, and (2) the effect of methoxyflurane on severity of ventricular arrhythmias produced by epinephrine. The former was determined by measuring the effect of methoxyflurane on the time required for appearance of ventricular arrhythmias during the continuous infusion of a standard, dilute solution of epinephrine. The latter was measured as the effect of methoxyfiurane on duration of ventricular arrhythmias produced by epinephrine. Duration of ventrieular arrhythmias was equated with severity on the basis that one or two abnormal ventricular contractions are not of the same significance as well established, continuing abnormal contractions. M~.a~aODSNine unanaesthetized, unmedicated mongrel dogs weighing between 12.5 and 22.5 kg were paralysed with succinylcholine to permit insertion of cuffed endotracheal tubes. Respirations were controlled by a non-rebreathing constant volume respirator set to deliver 4 L/min of 100 per cent oxygen. A thin-walled 16 gauge needle was inserted into an external jugular vein of each dog and a dilute (1 mg/ml) solution of succinylcholine was infused at the rate of

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Methoxyflurane and Teflurane

Poznak¹

1972

Modern Inhalation Anesthetics

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The effect of sympathetic blockade or hyperventilation on epinephrine-induced cardiac arrhythmias during anaesthesia with halothane and methoxyflurane

Cited by 6 publications

References 8 publications

Effects of Methoxyflurane (Penthrane) Anaesthesia in Children

Effects of Methoxyflurane (Penthrane) Anaesthesia in Children

Effect of methoxyflurane on epinephrine-induced ventricular arrhythmias

Methoxyflurane and Teflurane

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