The effect of systematic pediatric care on neonatal mortality and hospitalizations of infants born with oral clefts

Wehby, George L.; Castilla, Eduardo E.; Goco, Norman; Rittler, Mónica; Cosentino, Viviana; Javois, Lorette C.; Kindem, Mark; Chakraborty, Hrishikesh; Dutra, Graca; López-Camelo, Jorge S.; Orioli, Iêda M.; Murray, Jeffrey C.

doi:10.1186/1471-2431-11-121

Cited by 13 publications

(8 citation statements)

References 34 publications

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“…The majority of those affected with these types of clefting do not have defects in other tissues or organ systems, and, thus, they are referred to as non-syndromic ( Mossey and Modell, 2012 ). While these birth defects are largely repairable through surgical means, the financial, sociological, and psychological effects have a much broader impact and represent a significant public health burden ( Boulet et al, 2009 ; Wehby and Cassell, 2010 ; Wehby et al, 2011 , 2012 ). Screening, prevention, and non-surgical therapeutic options are thus highly desirable.…”

Section: Introductionmentioning

confidence: 99%

High-Resolution Epigenomic Atlas of Human Embryonic Craniofacial Development

et al. 2018

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SUMMARYDefects in patterning during human embryonic development frequently result in craniofacial abnormalities. The gene regulatory programs that build the craniofacial complex are likely controlled by information located between genes and within intronic sequences. However, systematic identification of regulatory sequences important for forming the human face has not been performed. Here, we describe comprehensive epigenomic annotations from human embryonic craniofacial tissues and systematic comparisons with multiple tissues and cell types. We identified thousands of tissue-specific craniofacial regulatory sequences and likely causal regions for rare craniofacial abnormalities. We demonstrate significant enrichment of common variants associated with orofacial clefting in enhancers active early in embryonic development, while those associated with normal facial variation are enriched near the end of the embryonic period. These data are provided in easily accessible formats for both craniofacial researchers and clinicians to aid future experimental design and interpretation of noncoding variation in those affected by craniofacial abnormalities.

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Section: Introductionmentioning

confidence: 99%

High-Resolution Epigenomic Atlas of Human Embryonic Craniofacial Development

et al. 2018

View full text Add to dashboard Cite

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“…The majority of those affected with these types of clefting do not have defects in other tissues or organ systems, and, thus, they are referred to as non-syndromic (Mossey and Modell, 2012). While these birth defects are largely repairable through surgical means, the financial, sociological, and psychological effects have a much broader impact and represent a significant public health burden (Boulet et al, 2009;Wehby and Cassell, 2010;Wehby et al, 2011Wehby et al, , 2012. Screening, prevention, and non-surgical therapeutic options are thus highly desirable.…”

Section: Introductionmentioning

confidence: 99%

High Resolution Epigenomic Atlas of Human Embryonic Craniofacial Development

et al. 2018

View full text Add to dashboard Cite

Defects in patterning during human embryonic development frequently result in craniofacial abnormalities. The gene regulatory programs that build the craniofacial complex are likely controlled by information located between genes and within intronic sequences. However, systematic identification of regulatory sequences important for forming the human face has not been performed. Here, we describe comprehensive epigenomic annotations from human embryonic craniofacial tissues and systematic comparisons with multiple tissues and cell types. We identified thousands of tissue-specific craniofacial regulatory sequences and likely causal regions for rare craniofacial abnormalities. We demonstrate significant enrichment of common variants associated with orofacial clefting in enhancers active early in embryonic development, while those associated with normal facial variation are enriched near the end of the embryonic period. These data are provided in easily accessible formats for both craniofacial researchers and clinicians to aid future experimental design and interpretation of noncoding variation in those affected by craniofacial abnormalities.

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“…[10] CL/P also increase infant mortality risks especially in less developed countries. [11] Later in childhood and adolescence, CL/P increase speech problems and behavioral risks due to dissatisfaction with facial appearance and speech. [12, 13] During adulthood, CL/P are associated with reduced education, lower marriage rates, poorer economic performance, [14] increased inpatient mental-health admissions, [15] and higher mortality and suicide risks.…”

mentioning

confidence: 99%

Does the Relationship between Prenatal Care and Birth Weight Vary by Oral Clefts? Evidence Using South American and United States Samples

Nyarko

López-Camelo

Castilla

et al. 2013

The Journal of Pediatrics

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Objective To evaluate if the association between prenatal care use and birth weight (BW) varies for infants with cleft lip and/or cleft palate (CL/P), classified into isolated and non-isolated forms, compared with unaffected infants. Study design The study employed two datasets. The first included a multi-country sample of 2,405 infants with CL/P and 24,046 infants without CL/P born in 1996–2007 in South America. The second was a sample of 2,122 infants with CL/P and 297,415 without CL/P from the United States (U.S.) 2004 Natality dataset. Separate analyses were performed for the South American and U.S. samples. The association between prenatal care and BW was evaluated separately for isolated CL/P, non-isolated CL/P, and unaffected infants using regression models adjusting for several background characteristics. Results Prenatal care was associated with improved BW for all infant groups, with greater BW increases for infants with CL/P particularly non-isolated forms. In the South American sample, BW increased by 108, 69, and 40 grams on average per prenatal visit for infants with non-isolated CL/P, infants with isolated CL/P, and unaffected infants, respectively. In the U.S. sample, BW increased by 51, 21, and 16 grams on average per prenatal visit for these infant groups, respectively. Conclusions Prenatal care was associated with larger BW increases for pregnancies complicated with CL/P, particularly non-isolated forms, compared with unaffected pregnancies. Given that reduced BW is a well-recognized co-morbidity of CL/P, the findings highlight the importance of prenatal care for at-risk pregnancies as a tertiary-prevention intervention to reduce the health burden of CL/P.

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The effect of systematic pediatric care on neonatal mortality and hospitalizations of infants born with oral clefts

Cited by 13 publications

References 34 publications

High-Resolution Epigenomic Atlas of Human Embryonic Craniofacial Development

High-Resolution Epigenomic Atlas of Human Embryonic Craniofacial Development

High Resolution Epigenomic Atlas of Human Embryonic Craniofacial Development

Does the Relationship between Prenatal Care and Birth Weight Vary by Oral Clefts? Evidence Using South American and United States Samples

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