The effect of systemic isotretinoin treatment on skin biophysicalparameters among patients with acne vulgaris*

Çölgeçen, Emine; Özyurt, Kemal; Kesikoğlu, Ayten Ferahbaş

doi:10.3906/sag-1507-31

Cited by 8 publications

(8 citation statements)

References 18 publications

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“…It is very important to know the impact of cosmetological procedures and treatment on the parameters of the skin in order to choose the periprocedural care. [11][12][13] The results of our research showed a decrease in the secretion of sebum on the face, which is confirmed by the studies of Barakat et al, which showed a 31% reduction in the surface of the sebaceous glands after the IPL treatment. No neutrophils were observed in the biopsy specimen, and total inflammation was reduced by 36%.…”

Section: Re Sultssupporting

confidence: 90%

Impact of IPL treatments on parameters of acne skin

Zdrada

Stolecka‐Warzecha

Odrzywołek

et al. 2022

J of Cosmetic Dermatology

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Background In the treatment of acne, skin parameters such as sebum secretion, hydration, and the content of hemoglobin and melanin are very important. The values of these parameters at the appropriate level show the maintenance of good functionality of the epidermal barrier and the impact of a given treatment procedure on the condition and physiology of the epidermis. Aims The aim of the study was to evaluate the effectiveness of anti‐acne therapy with IPL by volunteers, as well as to quantify parameters such as sebum secretion, hydration level, and the content of melanin and hemoglobin in the skin. Patients/Methods The study involved 27 volunteers with moderate acne. A series of 4 treatments was performed with intense pulse light at weekly intervals. The secretion of sebum, skin hydration, and the content of melanin and hemoglobin was measured. Results A decrease in sebum secretion in the forehead area after light treatments was observed, the level of hydration remained the same in all areas examined, as did the levels of melanin and hemoglobin. The volunteers were asked about the satisfaction with the effects of the treatment: 100% answered that they were satisfied with the effects of the treatment to a degree of 7.8 ± 1.5. Conclusions During anti‐acne therapy, therapists usually focus only on reducing acne lesions, forgetting that proper care has a large impact on the success of dermatological therapies. It is very important to know the influence of treatment procedures on the parameters of the skin in order to choose the right care for the best treatment effect.

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Section: Re Sultssupporting

confidence: 90%

Impact of IPL treatments on parameters of acne skin

Zdrada

Stolecka‐Warzecha

Odrzywołek

et al. 2022

J of Cosmetic Dermatology

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“…The main aim of the drugs used to treat acne, including isotretinoin, is to reduce sebum secretion [ 87 ]. This is supported by a study by Colgecen et al [ 86 ], in which it was observed that treatment with systemic isotretinoin resulted in a reduction in sebum secretion, and thus improved the biophysical properties of the skin of patients with acne vulgaris. The results of measurements of skin biophysical indices before and after isotretinoin treatment by Kmieć et al [ 26 ] also showed a reduction in the severity of sebum secretion after the intervention.…”

Section: Discussionsupporting

confidence: 55%

“…A reduction in mean TEWL values after 6 weeks of isotretinoin treatment for acne and rosacea was also observed by Kim et al [ 85 ]. On the other hand, Kmieć et al [ 26 ] observed an increase in TEWL values in acne patients receiving isotretinoin therapy, and Colgecen et al, observed no difference in TEWL values after 3 months of isotretinoin treatment [ 86 ]. Orally administered evening primrose oil improved TEWL in healthy adults [ 40 ].…”

Section: Discussionmentioning

confidence: 99%

Effect of Evening Primrose Oil Supplementation on Selected Parameters of Skin Condition in a Group of Patients Treated with Isotretinoin—A Randomized Double-Blind Trial

et al. 2022

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Background: Retinoids, which include isotretinoin, reduce sebum levels, the degree of epidermal wetness (CORN) and cause an increase in transepidermal water loss (TEWL). Weight gain has also been observed in isotretinoin-treated patients. An agent that can reduce the severity of isotretinoin side effects is evening primrose oil (Oenothera paradoxa). The purpose of this study was to evaluate the effect of evening primrose oil supplementation in patients with acne vulgaris treated with isotretinoin on skin hydration status (CORN), transepidermal water loss (TEWL), skin oiliness (sebum) and changes in body weight and BMI. Methods: Patients diagnosed with acne were assigned to the isotretinoin-treated group (n = 25) or the isotretinoin and evening primrose oil-treated group (n = 25). The intervention lasted 9 months. CORN (with a corneometer), TEWL (with a tewameter) and sebum (with a sebumeter) were assessed twice, as well as body weight and BMI (Tanita MC-780). Results: The isotretinoin-treated group showed statistically significant reductions in CORN (p = 0.015), TEWL (p = 0.004) and sebum (p < 0.001) after the intervention. In the group treated with isotretinoin and evening primrose oil, TEWL and sebum levels also decreased significantly (p < 0.05), while CORN levels increased from 42.0 ± 9.70 to 50.9 ± 10.4 (p = 0.017). A significant decrease in body weight (p < 0.001) and BMI (p < 0.001) was observed in both groups after 9 months of intervention. Conclusions: During isotretinoin treatment, supplementation with evening primrose oil increased skin hydration. However, there were no differences between groups in transepidermal water loss, skin oiliness, weight loss and BMI.

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“…Skin parameters, such as sebum production, melanin content, moisturization, TEWL, and erythema, were assessed using MPA‐5 diagnostic apparatus equipped with a sensor of external conditions consisting of Tewameter TM300, Mexameter MX 18, Corneometer CM825, and Sebumeter SM815 3 . Çölgeçen et al found a significant decrease in sebum level and stratum corneum hydration in 19 patients using 0.5–0.75 mg/kg/day isotretinoin for 3 months but found no difference in TEWL values 22 . Kmiec et al measured sebum, hydration, TEWL, erythema, and pH values before and after treatment to detect the mucocutaneous adverse effects of isotretinoin and found a significant reduction in all parameters compared to before.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of biophysical skin parameters and hair changes in patients with acne vulgaris treated with isotretinoin, and the effect of biotin use on these parameters

et al. 2021

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Aim Impairment of biotin metabolism with the use of isotretinoin and the mucocutaneous side effects observed in patients using isotretinoin suggests that they are a result of decreased enzyme activity. We aimed to determine the pattern of skin and hair changes in patients with acne receiving isotretinoin and how these changes were affected by biotin added to the treatment. Materials and methods Sixty patients were divided into two groups. Each group contained 30 patients. Groups A and B received 0.5 mg/kg/day isotretinoin, and 10 mg/day biotin supplement was added to Group B. Both groups were evaluated using a digital dermoscope for hair changes and with a DermaLab® Combo device for transepidermal water loss (TEWL), skin retraction, skin hydration, and skin sebum levels at the beginning and end of the fourth month. Results In group B, the anagen hair ratio increased (P = 0.034) and the telogen hair ratio decreased significantly (P = 0.003). Skin sebum and the skin retraction values decreased in both groups. Skin hydration decreased significantly in group A (P = 0.001), but there was no significant decrease in group B (P = 0.43). Conclusion Biotin (10 mg/day) given in addition to isotretinoin treatment decreased telogen and increased anagen hair rates and helped to maintain skin hydration. The use of 10 mg/day biotin can prevent the mucocutaneous adverse effects of isotretinoin treatment.

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The effect of systemic isotretinoin treatment on skin biophysicalparameters among patients with acne vulgaris*

Abstract: Treatment with systemic isotretinoin reduces sebum secretion and stratum corneum hydration and increases skin temperature, suggesting that isotretinoin may partially improve the biophysical characteristics of the skin among patients with acne vulgaris.

Cited by 8 publications

References 18 publications

Impact of IPL treatments on parameters of acne skin

Impact of IPL treatments on parameters of acne skin

Effect of Evening Primrose Oil Supplementation on Selected Parameters of Skin Condition in a Group of Patients Treated with Isotretinoin—A Randomized Double-Blind Trial

Evaluation of biophysical skin parameters and hair changes in patients with acne vulgaris treated with isotretinoin, and the effect of biotin use on these parameters

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