This study examined whether relationship orientation was associated positively with confronting sexism and whether confronting sexism was associated positively with competence, self-esteem, and empowerment for women but not men in stereotypically masculine domains. Men and women undergraduates from a United States Midwestern university (n=165) were exposed to a sexist statement during a staged, online interaction. Relationship orientation, confronting (i.e., publically rating the sexist statement as problematic and inappropriate), competence, self-esteem, and empowerment were assessed. Consistent with hypotheses, relationship orientation was associated positively with confronting. Additionally, confronting was associated positively with competence, self-esteem, and empowerment for women but not men. Implications for interpersonal confrontation, relationship orientation, and gender differences in response to everyday sexism are discussed.