The Effect of Taurine on 45Calcium Transport by Retinal Subcellular Fractions

Pasantes‐Morales, Herminia; Ademe, Rosa M.; López-Colomé, Ana Marı́a

doi:10.1007/978-94-009-8093-8_14

Cited by 6 publications

(6 citation statements)

References 48 publications

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“…More recently it was found that taurine fails to reduce lipid peroxidation, although it preserves the membrane organization of isolated rod outer segments and cultured human lymphoblastoid cells exposed to ferrous sulfate and retinoids, respectively [Pasantes-Morales and Cruz, 1984;Pasantes-Morales et al, 19841. These findings support an alternate hypothesis that the protective action of taurine might be related to its action on membrane permeability [Pasantes-Morales, 19861, as its effects on ion transport have been shown in a number of preparations [Gruener and Bryant, 1975;Pasantes-Morales et al, 1979, 1981aPasantes-Morales and Gamboa, 1980;Kruzinger and Hamprecht, 19811. It seems possible, therefore, that taurine plays a role in osmoregulation and protects photoreceptors from excessive influx of ions and water, which seems to result in the swelling of outer segments and mitochondria observed in the present study.…”

Section: Discussionsupporting

confidence: 73%

Retinal degeneration in 3‐month‐old rhesus monkey infants fed a taurine‐free human infant formula

Imaki

Moretz

Wisniewski

et al. 1987

J of Neuroscience Research

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Rhesus monkey infants were raised from birth on a taurine-free soy protein-based human infant formula or on the same formula supplemented with taurine. The monkeys were killed 3 months after birth and the retinas examined by light and electron microscopy. All of the monkeys raised on formula alone showed degenerative ultrastructural changes in photoreceptor outer segments that ranged from swelling and disorientation to fragmentation and disorganization. Cones were more severely affected than rods, and changes were most pronounced in the foveal region. Changes were also noted in the fine structure of the retinal pigment epithelium. These changes were prevented in all but one monkey fed the same formula supplemented with taurine. These results provide further support for the addition of taurine to commercial human infant formulas.

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Section: Discussionsupporting

confidence: 73%

Retinal degeneration in 3‐month‐old rhesus monkey infants fed a taurine‐free human infant formula

Imaki

Moretz

Wisniewski

et al. 1987

J of Neuroscience Research

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“…45Calcium accumulation by retinal subcellular fractions isolated from the chick retina is decreased when taurine is present in the incubation medium (34). This action of taurine is detected in a crude synaptosomal fraction containing pinched-off "conventional" nerve endings, as well as in isolated rod outer segments (34). Similar results were obtained by Huxtable et al (17) using a sarcolemma preparation.…”

Section: Taurine and Calcium Fluxessupporting

confidence: 52%

“…For this purpose, the effect of taurine on calcium transport was examined in various nervous preparations. 45Calcium accumulation by retinal subcellular fractions isolated from the chick retina is decreased when taurine is present in the incubation medium (34). This action of taurine is detected in a crude synaptosomal fraction containing pinched-off "conventional" nerve endings, as well as in isolated rod outer segments (34).…”

Section: Taurine and Calcium Fluxesmentioning

confidence: 99%

The Role of Taurine in Nervous Tissue: Its Effects on Ionic Fluxes

Pasantes‐Morales

Arzate

Cruz

1982

Advances in Experimental Medicine and Biology

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“…The modulation by taurine of calciummembrane interactions has been reported for various preparations, including rod outer segments [Pasantes-Morales et al, 1979Azari and Huxtable, 19801. Through this interaction, taurine might be contributing to membrane stabilization, and thus protect photoreceptor structure.…”

Section: Discussionmentioning

confidence: 96%

Effects of the taurine transport antagonist, guanidinoethane sulfonate, and β‐alanine on the morphology of rat retina

Pasantes‐Morales

Quesada

Cárabez

et al. 1983

J of Neuroscience Research

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Newborn rats treated for the first weeks of life with guanidinoethane sulfonate (GES), a blocker of taurine transport producing taurine depletion, showed a severe disruption of photoreceptor structure. Photoreceptor damage consisted of a marked reduction of the size of the photoreceptor layer, deformation of the outer segments, and a profound disorganization of the disc membranes. The GES-induced degeneration pattern was very similar to that observed in cats fed a taurine-deficient diet. Injection of beta-alanine, another antagonist of taurine transport, also produced a disruption of photoreceptor structure. These results confirm the requirement of taurine for maintaining photoreceptor structure in different species.

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The Effect of Taurine on 45Calcium Transport by Retinal Subcellular Fractions

Cited by 6 publications

References 48 publications

Retinal degeneration in 3‐month‐old rhesus monkey infants fed a taurine‐free human infant formula

Retinal degeneration in 3‐month‐old rhesus monkey infants fed a taurine‐free human infant formula

The Role of Taurine in Nervous Tissue: Its Effects on Ionic Fluxes

Effects of the taurine transport antagonist, guanidinoethane sulfonate, and β‐alanine on the morphology of rat retina

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