The effect of taurolidine on experimental thrombus formation

Kaptanoğlu, Levent; Küçük, Hasan Fehmi; Çolak, Elif; Kurt, Necmi; Bingul, Sadık; Akyol, Hüseyin; Torlak, Oguzhan Aziz; Yazıcı, Fatma

doi:10.1016/j.ejphar.2007.08.035

Cited by 21 publications

(14 citation statements)

References 4 publications

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“…Although taurolidine has shown to be able to decrease thrombus weight, but is not as effective as heparin in this respect [27], we observed a lowered incidence of catheter related occlusions with its use. Previous studies described a relationship between the number of CRBSI and occlusions, possibly due to infection-induced activation of the coagulation system [28].…”

Section: Discussioncontrasting

confidence: 65%

Taurolidine Lock Is Superior to Heparin Lock in the Prevention of Catheter Related Bloodstream Infections and Occlusions

et al. 2014

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Background and AimsPatients on home parenteral nutrition (HPN) are at risk for catheter-related complications; mainly infections and occlusions. We have previously shown in HPN patients presenting with catheter sepsis that catheter locking with taurolidine dramatically reduced re-infections when compared with heparin. Our HPN population therefore switched from heparin to taurolidine in 2008. The aim of the present study was to compare long-term effects of this catheter lock strategy on the occurrence of catheter-related bloodstream infections and occlusions in HPN patients.MethodsData of catheter-related complications were retrospectively collected from 212 patients who received HPN between January 2000 and November 2011, comprising 545 and 200 catheters during catheter lock therapy with heparin and taurolidine, respectively. We evaluated catheter-related bloodstream infection and occlusion incidence rates using Poisson-normal regression analysis. Incidence rate ratios were calculated by dividing incidence rates of heparin by those of taurolidine, adjusting for underlying disease, use of anticoagulants or immune suppressives, frequency of HPN/fluid administration, composition of infusion fluids, and duration of HPN/fluid use before catheter creation.ResultsBloodstream infection incidence rates were 1.1/year for heparin and 0.2/year for taurolidine locked catheters. Occlusion incidence rates were 0.2/year for heparin and 0.1/year for taurolidine locked catheters. Adjusted incidence ratios of heparin compared to taurolidine were 5.9 (95% confidence interval, 3.9–8.7) for bloodstream infections and 1.9 (95% confidence interval, 1.1–3.1) for occlusions.ConclusionsGiven that no other procedural changes than the catheter lock strategy were implemented during the observation period, these data strongly suggest that taurolidine decreases catheter-related bloodstream infections and occlusions in HPN patients compared with heparin.

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Section: Discussioncontrasting

confidence: 65%

Taurolidine Lock Is Superior to Heparin Lock in the Prevention of Catheter Related Bloodstream Infections and Occlusions

et al. 2014

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“…Furthermore, SMBE perhaps had some additional effect that prolongs occlusion time beyond what would be expected from the effect on cycloxygenase, or more generally on the synthesis of thromboxane and PGI2, especially for the lower SMBE doses. It is uncertain whether this is related to a differential effect on platelets rather than to actual thrombosis, and therefore needs to be further investigated [23,24].…”

Section: Discussionmentioning

confidence: 99%

Anti-thrombolytic effect of <i>Salvia miltiorrhiza</i> Bge extract in rats

Tian¹,

Wu²,

Zhang³

et al. 2017

Trop. J. Pharm Res

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“…Furthermore, CTL perhaps had some additional effect that prolongs occlusion time beyond what would be expected from the effect on cyclo-oxygenase, or more generally on the synthesis of thromboxane and PGI2, especially for the lower CTL doses. It is uncertain whether this is related to a differential effect on platelets rather than to actual thrombosis, and therefore needs to be further investigated [25,26].…”

Section: Discussionmentioning

confidence: 99%