The effect of TCDD on Acyl CoA: Retinol acyltransferase activity and vitamin a accumulation in the kidney of male sprague‐dawley rats

Jurek, Maria; Powers, Robert H.; Gilbert, Linda G.; Aust, Steven D.

doi:10.1002/jbt.2570050304

Cited by 22 publications

(6 citation statements)

References 19 publications

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“…The groups of animals in which hepatic EROD activity was induced were also the ones showing a depletion of hepatic andlor pulmonary vitamin A. In addition, these compounds decrease the retinoid-specific esterase and hydrolase activities in rat liver (Jensen et al 1987;Mercier et al 1990), whereas in rat kidney, retinoid-specific esterase activity increases following exposure to TCDD (Jurek et al 1990). On the other hand, TCDD and HxCB are known to enhance vitamin A catabolism by retinoidspecific cytochrome P450 and uridine diphosphoglucuronosyltransferase enzyme systems (Spear et al 1988;Bank et al 1989).…”

Section: Discussionmentioning

confidence: 99%

“…On the other hand, TCDD and HxCB are known to enhance vitamin A catabolism by retinoidspecific cytochrome P450 and uridine diphosphoglucuronosyltransferase enzyme systems (Spear et al 1988;Bank et al 1989). In addition, these compounds decrease the retinoid-specific esterase and hydrolase activities in rat liver (Jensen et al 1987;Mercier et al 1990), whereas in rat kidney, retinoid-specific esterase activity increases following exposure to TCDD (Jurek et al 1990). These data suggest that effects of "dioxin-like'' compounds on retinoid-specific enzyme activities may be important in the depletion of vitamin A.…”

Section: Livermentioning

confidence: 99%

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Effects of a Technical PCB Preparation and Fractions Thereof on Ethoxyresorufin O‐Deethylase Activity, Vitamin A Levels and Thymic Development in the Mink (Mustela vison)*

Brunström

Håkansson

Lundberg

1991

Pharmacology & Toxicology

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Clophen A50, a technical preparation of polychlorinated biphenyls (PCBs), was separated into four fractions; three containing chlorobiphenyls with 0, 1, or 2 to 4 ortho chlorines and one containing di- and tricyclic impurities such as naphthalenes and dibenzofurans. Clophen A50, the four fractions, and a synthetic mixture of the biologically most active non-ortho-chlorinated congeners (3,3',4,4'-tetra-, 3,3',4,4',5-penta-, and 3,3',4,4',5,5'-hexachlorobiphenyl), were separately mixed in the feed and given to female mink during the reproductive season. The concentration of a given compound in the feed mixture was equivalent to its concentration in the feed mixed with Clophen A50. Hepatic 7-ethoxyresorufin O-deethylase (EROD) activity in adults was enhanced 2-3 times by Clophen A50, the fractions containing non- or mono-ortho-chlorinated congeners, and the synthetic mixture. In neonatal kits delivered by females treated with non- or mono-ortho-chlorinated congeners, EROD was enhanced to about 30 times the control value. No live kits were delivered by the females treated with unfractionated Clophen A50. The fractions containing congeners with two to four ortho chlorines or di- and tricyclic compounds did not significantly induce EROD in either adults or kits. Clophen A50 reduced hepatic and pulmonary vitamin A contents in adult mink, while renal vitamin A was unaffected. Responses to the fractions containing the non- and mono-ortho-chlorinated congeners were similar to those obtained with Clophen A50. Their effects were, however, less pronounced, particularly with respect to the hepatic vitamin A reduction. The fractions containing congeners with two to four ortho chlorines and the di- and tricyclic compounds had no significant effects on tissue vitamin A contents.(ABSTRACT TRUNCATED AT 250 WORDS)

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Section: Discussionmentioning

confidence: 99%

Section: Livermentioning

confidence: 99%

Effects of a Technical PCB Preparation and Fractions Thereof on Ethoxyresorufin O‐Deethylase Activity, Vitamin A Levels and Thymic Development in the Mink (Mustela vison)*

Brunström

Håkansson

Lundberg

1991

Pharmacology & Toxicology

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“…Exposure of experimental animals, such as rats, mink and otters, to organochlorines leads to depletion of hepatic retinoid levels (Brunström et al 1991, Håkans-son et al 1992, Chu et al 1995, Murk et al 1998, Käkelä et al 1999, 2002, Kelley et al 2000, while those in the kidney generally increase (Brouwer et al 1989a, Jurek et al 1990, Nilsson et al 2000. This indicates that the pollutants mobilize retinoid storage forms, which is followed by an increase in their degradation and renal elimination through the urine (Kelley et al 1998(Kelley et al , 2000.…”

Section: Introductionmentioning

confidence: 98%

Tissue distribution of retinoids in common dolphins Delphinus delphis

Tornero

Borrell²,

Forcada³

et al. 2004

Mar. Ecol. Prog. Ser.

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Exposure to organochlorines induces retinoid deficiency in mammals; hence, retinoids are potential biomarkers of the impact of these pollutants. Appropriate target tissues to monitor retinoids in cetaceans have not been properly identified because of a lack of information on the contribution of each tissue to total body retinoids. Therefore, we have addressed this issue by studying the contribution of the main body tissues to retinoids in 21 common dolphins obtained from incidental catches and in apparent good health and nutritive condition. Although concentrations in the liver were highest, those in blubber were also high and accounted for 43% of the total retinoid load of the compartments examined. As blubber can be obtained using non-invasive biopsy techniques, this tissue is proposed as a reliable indicator of retinoid status in cetaceans. However, blubber topographical variation in structure and composition requires standardization of sampling sites. Retinoid concentrations did not differ significantly between sexes or with body size for any of the tissues, but the lipid content of blubber strongly influenced these concentrations. Biopsies from healthy, freeranging individuals are preferred to samples from stranded animals. Further research on the influence of factors (age, sex, reproductive condition, diet) that potentially affect retinoid levels is required to implement the use of retinoids as biomarkers of pollutant exposure in cetaceans.

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“…Extrahepatic tissues are involved in VA metabolism, especially during VA deficiency. Kidney has an auxiliary role during VA deficiency (28) due to increased acyl CoA:retinol acyl transferase activity. Lung contains retinyl esters (1,8,29,30) and can metabolize retinyl palmitate from chylomicron remnants into retinoic acid (31).…”

Section: Introductionmentioning

confidence: 99%

Vitamin A Concentrations in Piglet Extrahepatic Tissues Respond Differently Ten Days after Vitamin A Treatment

Sun

Surles

Tanumihardjo

2008

The Journal of Nutrition

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Periodic supplementation to infants and young children is encouraged in developing countries by the WHO. We investigated vitamin A (VA) in extrahepatic tissues of piglets after supplementation with retinyl acetate to determine long-term storage. 3, 4-Didehydroretinyl acetate (DRA) as a tracer was used to evaluate uptake from chylomicra in 4 h. Sows were fed a VA-depleted diet throughout pregnancy and lactation. Male castrated piglets (n = 28, 11.6 +/- 0.5 d) from these sows were weaned onto a VA-free diet for 1 wk, assigned to 4 groups, and dosed orally with 0, 26.2, 52.4, or 105 micromol VA. After 10 d, 5.3 micromol DRA was administered to determine short-term uptake of 3, 4-didehydroretinol (DR). Four hours later, piglets were killed; adrenal glands, kidney, lung, and spleen were collected and analyzed for retinol and DR. Retinol concentrations of kidney and adrenal gland were higher than control, but treated groups did not differ. Retinol concentration was highest in kidney (1.70-2.52 nmol/g), followed by adrenal gland (0.30-0.48 nmol/g), lung (0.15-0.21 nmol/g), and spleen (0.11-0.15 nmol/g). Total retinol in kidney and spleen was different among the groups (P < 0.05). Unesterified retinol was the major VA form; the percent retinol of total VA was lowest in adrenal glands. DR did not differ among the groups. In 4 h, the minimum estimated chylomicron contribution to tissue DR was 63-280% higher than the maximum DR exposure from retinol-binding protein. Constant dietary intake may be important in maintaining VA concentrations in extrahepatic tissues.

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The effect of TCDD on Acyl CoA: Retinol acyltransferase activity and vitamin a accumulation in the kidney of male sprague‐dawley rats

Cited by 22 publications

References 19 publications

Effects of a Technical PCB Preparation and Fractions Thereof on Ethoxyresorufin O‐Deethylase Activity, Vitamin A Levels and Thymic Development in the Mink (Mustela vison)*

Effects of a Technical PCB Preparation and Fractions Thereof on Ethoxyresorufin O‐Deethylase Activity, Vitamin A Levels and Thymic Development in the Mink (Mustela vison)*

Tissue distribution of retinoids in common dolphins Delphinus delphis

Vitamin A Concentrations in Piglet Extrahepatic Tissues Respond Differently Ten Days after Vitamin A Treatment

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