Objective To evaluate the effect of intervention by Teach-back and Douyin platform short video health education on stigma, reproductive quality of life, family intimacy and family adaptability in women receiving infertility treatment. Methods This study is a quasi-experimental study. The intervention period is 6 weeks, and the study was implemented between January 2022 and August 2022. A total of 80 women (40 in the control group and 40 in the observation group) receiving infertility treatment were included in the study. The control group was given routine health education intervention, and the observation group was given Teach-back and Douyin platform short video health education on the basis of routine health education. The Chinese version of the Infertility Stigma Scale, the Infertility Quality of Life Questionnaire and the Family Intimacy and Adaptability Scale were used to evaluate the effects before and after the intervention. Results After the intervention, the total score of stigma in the observation group was significantly lower and lower than that of the control group ( P < 0.05) and the total score of reproductive quality of life in the observation group was significantly higher than that of the control group ( P < 0.05). The dissatisfaction score of family intimacy in the observation group was significantly lower than that of the control group ( P < 0.05), and the dissatisfaction score of family adaptability in the observation group was significantly lower than that of the control group ( P < 0.05). Conclusion Teach-back and Douyin platform short video health education can reduce the stigma in women receiving infertility treatment and improve their reproductive quality of life, family intimacy and family adaptability.