The Effect of Temperature on Microtubule-Based Transport by Cytoplasmic Dynein and Kinesin-1 Motors

Hong, Wang; Takshak, Anjneya; Osunbayo, Olaolu; Kunwar, Ambarish; Vershinin, Michael

doi:10.1016/j.bpj.2016.09.040

Cited by 5 publications

(1 citation statement)

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“…Here we considered only as examples of possible external parameter the viscosity of the surrounding medium, or the ATP concentration. But many other choices would be possible as long as both teams react in a different way to the variations of the parameter [36].…”

Section: Tug-of-warmentioning

confidence: 99%

Transport in Physical Space: The Example of Pedestrians, Cars, and Molecular Motors

Appert-Rolland

Klein

Ebbinghaus

et al. 2017

Proceedings of the Asia-Pacific Econophysics Conference 2016 — Big Data Analysis and Modeling Toward Super Smart Society — (APE

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Transport systems in physical space exhibit various phenomena which may have some counterparts in socio-or econo-systems. We review here several of them. In highway vehicular traffic, the introduction of a reaction time leads to metastability and hysteresis. Pattern formation occurs in pedestrian flows. At a microscopic scale, we can learn from molecular pedestrians that transporting an object by opposite teams can be more efficient in a crowded environment and allow for an easy control of the system. Besides, we will show that the interplay between transport and the dynamics of the underlying network can sometimes lead to positive effects in terms of efficiency of transport.

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Section: Tug-of-warmentioning

confidence: 99%

Transport in Physical Space: The Example of Pedestrians, Cars, and Molecular Motors

Appert-Rolland

Klein

Ebbinghaus

et al. 2017

Proceedings of the Asia-Pacific Econophysics Conference 2016 — Big Data Analysis and Modeling Toward Super Smart Society — (APE

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Single-molecule dynein motor mechanics in vitro

Yıldız

2018

Dyneins

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Ca_Vβ controls the endocytic turnover of Ca_V1.2 L‐type calcium channel

Conrad

Kortzak

Guzman

et al. 2021

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Membrane depolarization activates the multisubunit CaV1.2 L‐type calcium channel initiating various excitation coupling responses. Intracellular trafficking into and out of the plasma membrane regulates the channel's surface expression and stability, and thus, the strength of CaV1.2‐mediated Ca2+ signals. The mechanisms regulating the residency time of the channel at the cell membrane are unclear. Here, we coexpressed the channel core complex CaV1.2α1 pore‐forming and auxiliary CaVβ subunits and analyzed their trafficking dynamics from single‐particle‐tracking trajectories. Speed histograms obtained for each subunit were best fitted to a sum of diffusive and directed motion terms. The same mean speed for the highest‐mobility state underlying directed motion was found for all subunits. The frequency of this component increased by covalent linkage of CaVβ to CaV1.2α1 suggesting that high‐speed transport occurs in association with CaVβ. Selective tracking of CaV1.2α1 along the postendocytic pathway failed to show the highly mobile state, implying CaVβ‐independent retrograde transport. Retrograde speeds of CaV1.2α1 are compatible with myosin VI‐mediated backward transport. Moreover, residency time at the cell surface was significantly prolonged when CaV1.2α1 was covalently linked to CaVβ. Thus, CaVβ promotes fast transport speed along anterograde trafficking and acts as a molecular switch controlling the endocytic turnover of L‐type calcium channels.

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The Effect of Temperature on Microtubule-Based Transport by Cytoplasmic Dynein and Kinesin-1 Motors

Cited by 5 publications

References 0 publications

Transport in Physical Space: The Example of Pedestrians, Cars, and Molecular Motors

Transport in Physical Space: The Example of Pedestrians, Cars, and Molecular Motors

Single-molecule dynein motor mechanics in vitro

Ca_Vβ controls the endocytic turnover of Ca_V1.2 L‐type calcium channel

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The Effect of Temperature on Microtubule-Based Transport by Cytoplasmic Dynein and Kinesin-1 Motors

Cited by 5 publications

References 0 publications

Transport in Physical Space: The Example of Pedestrians, Cars, and Molecular Motors

Transport in Physical Space: The Example of Pedestrians, Cars, and Molecular Motors

Single-molecule dynein motor mechanics in vitro

CaVβ controls the endocytic turnover of CaV1.2 L‐type calcium channel

Contact Info

Product

Resources

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Ca_Vβ controls the endocytic turnover of Ca_V1.2 L‐type calcium channel