2012
DOI: 10.1111/j.1365-2044.2011.07006.x
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The effect of temperature on di(2‐ethylhexyl) phthalate leaching from PVC infusion sets exposed to lipid emulsions

Abstract: SummaryPoly vinyl chloride (PVC) infusion equipment contains substantial amounts of the plasticiser di(2-ethylhexyl) phthalate (DEHP). We determined the amount of DEHP leached from Mediplus Dual TIVA Ò Infusion sets, into lipid and nonlipid infusates. Two propofol admixtures (Diprivan Ò 1%, Propoven Ò 1%), Intralipid Ò 10% and 0.9% saline were evaluated as infusates. Solutions were infused through TIVA sets at 12 ml.h )1 for 6 h at 24, 32 and 37°C. In addition, TIVA sets were filled with 2 ml infusates, sealed… Show more

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Cited by 39 publications
(27 citation statements)
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“…This heavy use is an important consideration given the extensive amounts of one-time-use materials that are consumed in hospitals. As such, Table 1 provides data on the leaching of DEHP from some commonly used hospital equipment, such as infusion sets (Bagel et al 2011;Rose et al 2012), tubings (Takehisa et al 2005), PVC storage bags (Demore et al 2002;Veiga et al 2012), and PVC blood bags (Buchta et al 2005;Inoue et al 2005;Jaeger and Rubin 1972;Peck et al 1979;Rock et al 1978). Concentrations of DEHP in leachates from such equipment are significantly greater than what has been reported in water and foods, as was discussed above.…”
Section: Hospital Equipmentmentioning
confidence: 83%
“…This heavy use is an important consideration given the extensive amounts of one-time-use materials that are consumed in hospitals. As such, Table 1 provides data on the leaching of DEHP from some commonly used hospital equipment, such as infusion sets (Bagel et al 2011;Rose et al 2012), tubings (Takehisa et al 2005), PVC storage bags (Demore et al 2002;Veiga et al 2012), and PVC blood bags (Buchta et al 2005;Inoue et al 2005;Jaeger and Rubin 1972;Peck et al 1979;Rock et al 1978). Concentrations of DEHP in leachates from such equipment are significantly greater than what has been reported in water and foods, as was discussed above.…”
Section: Hospital Equipmentmentioning
confidence: 83%
“…and predicable exposure conditions. For example, it has clearly been highlighted that DEHP's leach out from PVC tubings was increased by the incubation temperature (Loff et al, 2002;Bourdeaux et al, 2004;Rose et al, 2012). This aims to verify if the released amounts of each plasticizer would correspond to the doses to which the patients are exposed through infusion procedures, and to estimate tolerable limit doses before toxicity.…”
Section: Discussionmentioning
confidence: 96%
“…The authors confirmed that DINCH and TOTM are safe for the T-Prod disrupt. But at present, the validity of extrapolating animal data to man remains unresolved (Rose et al 2012), as well as significant differences can be observed between neonates and adults, due in particular to the enzymatic an metabolic immaturity (see for example conversion of DEHP into MEHP in neonates (Latinietal.,2004)). Moreover,allthesetoxicologicalstudies have been performed using the oral route.…”
Section: Discussionmentioning
confidence: 99%
“…We targeted our survey at the "at risk" health services (adult ICU) ( [12] [13][3]) due to the frequency and the abundance of the infusion acts, whether they are sequential or simultaneous, as well as the nature of the fluids infused. For this last point in particular, our analysis had to be expanded to the adult cancer services (extracting power of excipients from some cancer chemotherapies).…”
Section: Rd Stage: Identification Of the Exposure Conditionsmentioning
confidence: 99%