The relationship between deformation and dehydration has been investigated in Hercynian regionally metamorphosed rocks exposed on NW Sardinia. Two episodes of prograde mineral growth (M 1 & M 2 ) involving dehydration are recognized: growth of chlorite/phengite porphyroblasts at anchizone metamorphic conditions, contemporaneous with the first phase of deformation, D 1, and growth of biotite from chlorite and phengite coincident with the second phase of deformation, D 2 . Deformation during both episodes of dehydration is characterized by penetrative axial planar foliations defined by well-developed phyllosilicate preferred orientations quantified by XRD textural goniometry, tight to isoclinal similar folds (interlimb angles <40°), and mineral-filled veins (hydrofractures) orientated parallel to axial planar foliations, that formed contemporaneously with the development of the penetrative foliations. No prograde mineral growth occurred during D 2 at chlorite-zone conditions. D 2 deformation in the absence of dehydration is characterized by non-penetrative crenulation cleavages, poorly developed phyllosilicate preferred orientations, relatively open (interlimb angles >40°), low-strain similar folds and minor brittle deformation. Systematic variations in macrofold interlimb angles, with respect to the timing of mineral growth, indicate that enhanced shortening (c. 80%) occurred during dehydration. Microfabrics show that the onset of dehydration is associated with the transition from a crenulation cleavage to a penetrative foliation. The presence of axial planar hydrofractures that formed coevally with dehydration and fabric development requires that supralithostatic fluid pressures and low differential stresses (