“…Metabolic effects.-Several symptoms and signs are to be ascribed to metabolic changes, which include re-mineralization of the bones (Farrow and Woodard, 1942), retention of water, electrolytes and nitrogen (Kenyon, Sandiford, Hughes, Knowlton and Koch, 1938;Abels, Nelson, Young and Taylor, 1944), and others less easy to define. The patients become alert and active, and gain strength and weight.…”