2016
DOI: 10.1186/s13643-016-0358-6
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The effect of the 2-week wait referral system on the detection of and mortality from colorectal cancer: protocol of a systematic review and meta-analysis

Abstract: BackgroundColorectal cancer represents the fourth most common cancer in England and Wales; survival is high for early stage disease but declines sharply with advanced stage. UK figures suggest that cancer survival rates are lower than those of other Western European countries. Current 5-year survival is around 50 %. A rapid access strategy was introduced through the Department of Health in 2000. This 2-week wait (TWW) referral pathway was devised to streamline referral for suspected cancer, allow diagnosis at … Show more

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Cited by 9 publications
(3 citation statements)
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“…The current 2-week wait (TWW) referral pathway implemented by the UK Department of Health in 2000 was meant to streamline patients suspected of having cancer, in the most effective manner. However, as this is predicated on symptoms, signs and blood tests, resulting in only 12% of all CRC detected through this pathway5 and only 9% of TWW referrals resulted in the detection and treatment of CRC 6. The NG12 guideline (2015) recommends referral via the TWW pathway if occult blood is found in faeces on testing by the guaiac method 7.…”
Section: Introductionmentioning
confidence: 99%
“…The current 2-week wait (TWW) referral pathway implemented by the UK Department of Health in 2000 was meant to streamline patients suspected of having cancer, in the most effective manner. However, as this is predicated on symptoms, signs and blood tests, resulting in only 12% of all CRC detected through this pathway5 and only 9% of TWW referrals resulted in the detection and treatment of CRC 6. The NG12 guideline (2015) recommends referral via the TWW pathway if occult blood is found in faeces on testing by the guaiac method 7.…”
Section: Introductionmentioning
confidence: 99%
“…The year 2000 saw the introduction of the two-week wait diagnostics referral processes for suspected cancer to improve cancer detection times. 33 Whilst this is likely to result in early intervention, it can cause increased patient anxiety, distress, unnecessary intervention and pressure on already stretched diagnostic services, and pressures are set to continue increasing. This route also requires GPs to have the knowledge to be able to order the correct test.…”
Section: Discussionmentioning
confidence: 99%
“…A large number of patients undergo unnecessary colonoscopies, which are invasive and carry risks such as procedural complications, overdiagnosis and overtreatment. The lack of patient awareness regarding red-flag symptoms delays the seeking of help and, along with inappropriate use of the 2-week referral system in some cases, has been associated with the unsatisfactory outcomes of the current strategy 4,5 .…”
Section: Introductionmentioning
confidence: 99%