The effect of the addition of Bordetella parapertussis suspensions on the protective power of the pertussis component of diphtheria–tetanus–pertussis vaccines

Abstract

The addition of a parapertussis component to diphtheria–tetanus–pertussis vaccine reduces the agglutinogenic potency of the pertussis component in mice. The loss is evident when the amount of the parapertussis component added is 25% of that of the pertussis component, while the influence of relatively lower amounts of parapertussis organisms is less striking.The parapertussis component in these vaccines, amounting to 2–25% of the pertussis component, does not affect the protective power of the pertussis component in mice.