The effect of the anaesthetic agent isoflurane on the rate of neutrophil apoptosisin vitro

Tyther, Raymond; Fanning, Noel; Halligan, M.; Wang, J.; Redmond, H. P.; Shorten, George

doi:10.1007/bf03167720

Cited by 37 publications

(9 citation statements)

References 25 publications

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“…Despite these findings that isoflurane may induce neurotoxicity, there have been many reports that isoflurane may protect against neurotoxicity (de Klaver et al, 2002; Gray et al, 2005; Kawaguchi et al, 2004; Li et al, 2008; Raphael et al, 2008; Tyther et al, 2001; Wise-Faberowski et al, 2004; Wise-Faberowski et al, 2001; Xu et al, 2008; Zaugg et al, 2000). Importantly, isoflurane's protection effects have been shown to be dose- and time-dependent.…”

Section: Effects Of Anesthetics On Aβ Levelsmentioning

confidence: 99%

General anesthetics and β-amyloid protein

Xie

2013

Progress in Neuro-Psychopharmacology and Biological Psychiatry

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With roughly 234 million people undergoing surgery with anesthesia each year worldwide, it is important to determine whether commonly used anesthetics can induce any neurotoxicity. Alzheimer's disease (AD) is the most common form of age-related dementia, and a rapidly growing health problem. Several studies suggest that anesthesia could be associated with the development of AD. Moreover, studies in cultured cells and animals show that commonly used inhalation anesthetics may induce changes consistent with AD neuropathogenesis, e.g., β-amyloid protein accumulation. Therefore, in this mini review, we focus on the recent research investigating the effects of commonly used anesthetics including isoflurane, sevoflurane, desflurane, nitrous oxide, and propofol, on Aβ accumulation in vitro and in vivo. We further discuss the future direction of the research determining the effects of anesthetics on β-amyloid protein accumulation.

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Section: Effects Of Anesthetics On Aβ Levelsmentioning

confidence: 99%

General anesthetics and β-amyloid protein

Xie

2013

Progress in Neuro-Psychopharmacology and Biological Psychiatry

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“…In 1985 cases of cancer were described in nurses exposed to anaesthetics [74]. DNA single-strand breaks in peripheral lymphocytes of personnel with occupational exposure to anaesthetics has also been mentioned [75,76] as well as its effect on the rate of neutrophil apoptosis [77]. Chromosome analysis of samples from operating room personnel registered the same mutagenic changes [78].…”

Section: Air Monitoringmentioning

confidence: 99%

Air Quality in Operating Theatres: The Effect of Waste Anaesthetics on Personnel and Exposure Prevention Measures

Dobrovolsky¹

2003

Indoor and Built Environment

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The use of gaseous anaesthetics and vapours for narcosis in operating theatres means that inevitably some fraction of these is breathed by the surgical team. The amount will depend on the anaesthetic method, the duration of the operation, and the condition of the equipment used for anaesthesia and for overall ventilation. The greatest concentrations of anaesthetics are found in the working zone of the anaesthetist, then the surgeon and the scrub nurse. Until the middle of the 1960s there was little interest in air quality in operating theatres and the occupational effect of waste anaesthetic agents on the surgical team. The situation has improved considerably since then and many studies have now been carried out.

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“…TYTHER et al (2001; found isoflurane and sevoflurane to cause dose-dependent inhibition of polymorphonuclear neutrophil apoptosis in vivo and in vitro. MOUDGIL and SINGAL (1997) showed that equipotent concentrations of isoflurane, enflurane, halothane and methoxyflurane in a gas mixture with 70% nitrous oxide influenced the chemotactic activity of neutrophils and monocytes.…”

mentioning

confidence: 93%

“…Isoflurane (TYTHER et al, 2001) and sevoflurane (TYTHER et al, 2003) were found to induce dose-dependent inhibition of polymorphonuclear neutrophil apoptosis in vivo and in vitro. as reported by MORISAKI et al (1998), total lymphocyte count did not change following sevoflurane anesthesia, but neutrophil count was observed to decrease while lymphocyte count increased.…”

mentioning

confidence: 97%

The effect of repeated sevoflurane and nitrous oxide exposure on immunity in rabbits

Adam¹,

Marin²,

Popović³

et al. 2018

Vet. arhiv

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: The effect of repeated sevoflurane and nitrous oxide exposure on immunity in rabbits. Vet. arhiv 88, 37-48, 2018. ABSTrACTThe aim of this study was to investigate the effect of repeated/prolonged exposure to sevoflurane and nitrous oxide on the immune response in rabbits. Venous blood samples were obtained from twenty New Zealand rabbits, randomly allocated to four groups of five rabbits each. Group A rabbits served as controls, breathing 100% oxygen, group B rabbits inhaled a mixture of oxygen and nitrous oxide, group C inhaled a combination of oxygen and sevoflurane, and group D inhaled a combination of oxygen, nitrous oxide and sevoflurane. Flow cytometry was used to determine the proportions of CD45+ and CD21 + leukocytes subpopulations. Peripheral lymph nodes, lungs and spleen were sampled and subjected to histologic examination. the greatest changes in the proportion of CD21 + and CD45 + cell counts on day 0 and day 21 showed a 30% decrease. This study demonstrated that sevoflurane alone and in combination with nitrous oxide exerts a strong immunosuppressive effect, modifying the physiological values of the hematologic parameters, and inducing histopathological alterations in peripheral lymph node, lung and spleen tissues.

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The effect of the anaesthetic agent isoflurane on the rate of neutrophil apoptosisin vitro

Abstract: Human neutrophil apoptosis is inhibited in a concentration-dependent manner in vitro by isoflurane in clinical concentrations.

Cited by 37 publications

References 25 publications

General anesthetics and β-amyloid protein

General anesthetics and β-amyloid protein

Air Quality in Operating Theatres: The Effect of Waste Anaesthetics on Personnel and Exposure Prevention Measures

The effect of repeated sevoflurane and nitrous oxide exposure on immunity in rabbits

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