The effect of the biochemical marker soluble human leukocyte antigen G on pregnancy outcome in assisted reproductive technology—a multicenter study

Kotzé, Dirk; Kruger, Thinus F.; Lombard, Carl; Padayachee, Trishanta; Keskintepe, Levent; Sher, Geoffrey

doi:10.1016/j.fertnstert.2013.07.1977

Cited by 39 publications

(31 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The incidence of an ongoing pregnancy was 2.52 times greater in embryos transferred on day 3 with a positive sHLA-G test result than the incidence of an ongoing pregnancy in embryos with a negative sHLA-G test result. As a conclusion, data from this multicenter study confirm that sHLA-G expression is a valuable noninvasive embryo marker to assist in improving pregnancy outcomes (Kotze et al, 2013).…”

Section: Hla-g and Pregnancy Related Problemssupporting

confidence: 67%

HLA-E, HLA-F and HLA-G — The Non-Classical Side of the MHC Cluster

Foroni¹,

Couto²,

Bettencourt³

et al. 2014

HLA and Associated Important Diseases

View full text Add to dashboard Cite

Section: Hla-g and Pregnancy Related Problemssupporting

confidence: 67%

HLA-E, HLA-F and HLA-G — The Non-Classical Side of the MHC Cluster

Foroni¹,

Couto²,

Bettencourt³

et al. 2014

HLA and Associated Important Diseases

View full text Add to dashboard Cite

“…These may act in a similar manner to ligand binding proteins, such as follistatin and IGF binding proteins (IGFBPs) (25). HLA-G receptor in membrane-bound form has been reported in preimplantation embryos but can also be detected in spent embryo culture media as a soluble receptor (sHLA-G) (136,138,145). De los Santos et al (46) reported that although embryos expressed IL-1 receptors, a significant amount of free IL protein could be found in culture supernatants, suggesting proteolytic cleavage or other mechanisms that liberate membrane-bound receptors.…”

Section: E Critical Analysis and Knowledge Gaps In Receptor Expressimentioning

confidence: 99%

Soluble Ligands and Their Receptors in Human Embryo Development and Implantation

et al. 2015

View full text Add to dashboard Cite

Extensive evidence suggests that soluble ligands and their receptors mediate human preimplantation embryo development and implantation. Progress in this complex area has been ongoing since the 1980s, with an ever-increasing list of candidates. This article specifically reviews evidence of soluble ligands and their receptors in the human preimplantation stage embryo and female reproductive tract. The focus will be on candidates produced by the human preimplantation embryo and those eliciting developmental responses in vitro, as well as endometrial factors related to implantation and receptivity. Pathways to clinical translation, including innovative diagnostics and other technologies, are also highlighted, drawing from this collective evidence toward facilitating joint improvements in embryo quality and endometrial receptivity. This strategy could not only benefit clinical outcomes in reproductive medicine but also provide broader insights into the peri-implantation period of human development to improve fetal and neonatal health.

show abstract

“…Also, in in vitro fertilization (IVF) treatments, the measurement of sHLA-G in the embryo culture medium can be used as a marker for improving successful assisted reproductive technology, by choosing the fertilized oocytes with highest potential, as sHLA-G positive culture medium correlates with pregnancy success (10, 58, 106). …”

Section: Future Aspects and Conclusionmentioning

confidence: 99%

Controlling the Immunological Crosstalk during Conception and Pregnancy: HLA-G in Reproduction

2014

View full text Add to dashboard Cite

In several years after its discovery in the placenta, the human leukocyte antigen (HLA) class Ib protein, HLA-G, was not given much attention, nor was it assigned great importance. As time has unraveled, HLA-G has proven to have distinctive functions and an unforeseen and possibly important role in reproduction. HLA-G is characterized mainly by its low polymorphism and restricted tissue distribution in non-pathological conditions. In fact, its expression pattern is primarily limited to extravillous cytotrophoblast cells at the maternal-fetal interface during pregnancy. Due to low polymorphism, almost the same protein is expressed by virtually all individuals. It is these unique features that make HLA-G differ from its highly polymorphic HLA class Ia counterparts, the HLA-A, -B, and -C molecules. Its function, seemingly diverse, is typically receptor-mediated, and involves interactions with a wide range of immune cells. As the expression of HLA-G primarily is limited to gestation, this has given rise to the hypothesis that HLA-G plays an important role in the immunological tolerance of the fetus by the mother. In keeping with this, it might not be surprising that polymorphisms in the HLA-G gene, and levels of HLA-G expression, have been linked to reproductive failure and pre-eclampsia. Based on recent studies, we speculate that HLA-G might be involved in mechanisms in reproductive immunology even before conception because HLA-G can be detected in the genital tract and in the blood of non-pregnant women, and is present in seminal fluid from men. In addition, HLA-G expression has been found in the pre-implanted embryo. Therefore, we propose that a combined contribution from the mother, the father, and the embryo/fetus is likely to be important. Furthermore, this review presents important aspects of HLA-G in relation to reproduction: from genetics to physiological effects, from pregnancy and pregnancy complications to a short discussion on future possible means of preventative measures and therapy.

show abstract

The effect of the biochemical marker soluble human leukocyte antigen G on pregnancy outcome in assisted reproductive technology—a multicenter study

Cited by 39 publications

References 35 publications

HLA-E, HLA-F and HLA-G — The Non-Classical Side of the MHC Cluster

HLA-E, HLA-F and HLA-G — The Non-Classical Side of the MHC Cluster

Soluble Ligands and Their Receptors in Human Embryo Development and Implantation

Controlling the Immunological Crosstalk during Conception and Pregnancy: HLA-G in Reproduction

Contact Info

Product

Resources

About