The Effect of the Concentration of D-Glucose on the Attack of Tooth Substances in the Artificial Mouth

Pigman, Ward; Hawkins, William L.; Watson, Jason; Powell, Ralph D.; Gaston, Carolyn

doi:10.1177/00220345550340040901

Cited by 13 publications

(2 citation statements)

References 5 publications

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“…Res. workers8, 9,12,26,32,34 have reported that teeth show considerable variability in their ability to withstand attack of microorganisms or acids. The use of older teeth might have greatly increased the differences in behavior of the various tooth tissues, especially the surface enamel.…”

Section: Discussionmentioning

confidence: 99%

The Action of Individual Bacterial Strains on Human Teeth Under in Vitro Conditions

et al. 1957

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Section: Discussionmentioning

confidence: 99%

The Action of Individual Bacterial Strains on Human Teeth Under in Vitro Conditions

et al. 1957

Self Cite

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“…This experimental setup focused on identifying conditions that favour cariogenesis; Pigman's model is arguably an ancestor to contemporary drip‐fed systems (discussed later in this review). From the 1950s to the 1960s, many in vitro oral studies improved Pigman's artificial mouth system by including an incubator cabinet and sterilization with ethylene oxide (Pigman et al, 1955, 1962; Pigman & Newbrun, 1962). From a fundamental perspective, these studies linked common dietary sugars, for example, glucose and sucrose, to cariogenicity.…”

Section: Past and Present: Oral In Vitro Biofilm Modelsmentioning

confidence: 99%

In vitro model systems for exploring oral biofilms: From single‐species populations to complex multi‐species communities

Luo

Vanek

González-Cabezas

et al. 2021

J of Applied Microbiology

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Numerous in vitro biofilm model systems are available to study oral biofilms. Over the past several decades, increased understanding of oral biology and advances in technology have facilitated more accurate simulation of intraoral conditions and have allowed for the increased generalizability of in vitro oral biofilm studies. The integration of contemporary systems with confocal microscopy and 16S rRNA community profiling have enhanced the capabilities of in vitro biofilm model systems to quantify biofilm architecture and analyze microbial community composition. In this review, we describe several model systems relevant to modern in vitro oral biofilm studies: the constant depth film fermenter, Sorbarod perfusion system, drip-flow reactor, modified Robbins device, flowcells, and microfluidic systems. We highlight how combining these systems with confocal microscopy and community composition analysis tools aids exploration of oral biofilm development under different conditions and in response to antimicrobial/anti-biofilm agents. The review closes with a discussion of future directions for the field of in vitro oral biofilm imaging and analysis. Introduction: Importance of in vitro model systems to the study of oral biofilmsMicroorganisms form dynamic multi-species biofilm communities on numerous surfaces in the human oral cavity (Marsh 2009). Over time, oral biofilms change in composition and architecture as component microbes interact with each other, the environment, and the host (Lamont et al. 2018). Oral biofilm communities can be extremely resilient; redeveloping rapidly after physical perturbations (e.g. brushing or flossing) and chemical treatments (e.g. application of mouthwash) (Marsh 2010). Furthermore, certain ecological and environmental conditions can alter the microbial composition and behavior of oral biofilm communities resulting in dental caries and periodontal disease (Aas et al. 2008;Peterson et al. 2013;Marsh 2018). Dental caries and periodontal disease are among the most prevalent of human diseases (Petersen et al. 2005) ranking 1 and 11 in a 2016 ranking of global health burden of 328 diseases (Vos and Collaborators 2017). In 2016, an estimated 2.44 billion people had active dental caries while

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Histologic studies of carious-like lesions produced in the artificial mouth

Pigman

Sognnaes

1955

Oral Surgery, Oral Medicine, Oral Pathology

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The Effect of the Concentration of D-Glucose on the Attack of Tooth Substances in the Artificial Mouth

Cited by 13 publications

References 5 publications

The Action of Individual Bacterial Strains on Human Teeth Under in Vitro Conditions

The Action of Individual Bacterial Strains on Human Teeth Under in Vitro Conditions

In vitro model systems for exploring oral biofilms: From single‐species populations to complex multi‐species communities

Histologic studies of carious-like lesions produced in the artificial mouth

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