The Effect of the Drug Estrofan on the Content of Nitric Oxide (II), Sex Hormones, Biochemical Parameters and Their Relationship in Cows

Abstract

The physiological functions of nitric oxide (II) are diverse, and its therapeutic uses continue to expand. Many methods have been found to regulate the production of this compound, both physiological, regulated by the body itself, and as a result of various, drug and non-drug, external influences, correcting the ability of cells, organs and tissues to produce nitric oxide (II). The drug estrophan (synthetic prostaglandin PGF2α) has an activating effect on the nitric oxide (II) system and on sex hormones that regulate the reproductive functions of cows. The introduction of estrophan to cows is accompanied by an increase in the synthesis of nitric oxide (II), estrogen in the body of cows, and a decrease in progesterone. A high level of interrelation of estrogen with nitric oxide (II) was shown, the value of the correlation coefficient is (r = 0.552; p < 0.05). Correlation of the level of nitric oxide (II) with estrogen allows making an assumption of its bioregulatory functions, including the sexual cycle. The introduction of estrophan had no effect on the biochemical parameters in the blood serum of cows.