The Effect of the EGFR - Targeting Compound 3-[(4-Phenylpyrimidin-2-yl) Amino] Benzene-1-Sulfonamide (13f) against Cholangiocarcinoma Cell Lines

Phyllanthus emblica: a comprehensive review of its phytochemical composition and pharmacological properties

“…These findings collectively suggest that Phyllanthus emblica demonstrates its anticancer efficacy by concurrently inhibiting AP-1 and targeting the transcription of viral oncogenes responsible for the development of cervical cancer, thereby indicating its potential utility in the treatment of HPV-induced cervical cancer cells (Mahata et al, 2013;Quranayati et al, 2022). In a separate investigation by Samatiwat et al (2021), the anti-proliferative activity of the ethanolic extract of Phyllanthus emblica bark was assessed in the context of cholangiocarcinoma. The results highlighted the extract's cytotoxic potential on the KKU-452 CCA cell line, with an IC50 value of 52.2 μg/mL, accompanied by a significant induction of apoptosis.…”

“…Furthermore, the ethanolic extract of Phyllanthus emblica bark substantially inhibited cell migration at concentrations of 25 and 50 μg/mL, with reductions of 425% and 32.9%, respectively, compared to untreated cells. These anticancer effects were attributed to the phenolic acid and flavonoid content present in the bark extract of Phyllanthus emblica (Samatiwat et al, 2021). The anticancer potential of Phyllanthus emblica is graphically illustrated in Figure 6.…”

Potential anti-cancer properties of some selected medicinal plants

“…Exploring the potential of the ethanolic extract of Phyllanthus emblica bark, researchers investigated its anti-proliferative activity in the context of cholangiocarcinoma. Phenolic acid and flavonoids in Phyllanthus emblica bark extract contribute to its anticancer effects(Samatiwat, 2021). In vitro proliferation assays, employing the 3-(4,5-Dimethylthiazol-2yl)-2,5-diphenyltetrazolium bromide procedure, revealed the anticancer potential of six phenolic compounds…”