The effect of the herbal medicine on severity of cyclic mastalgia: a systematic review and meta-analysis

Tabrizi, Shirin; Meedya, Shahla; Ghassab-Abdollahia, Nafiseh; Ghorbani, Zahra; Jahangiry, Leila; Mirghafourvand, Mojgan

doi:10.1515/jcim-2020-0531

Cited by 2 publications

(1 citation statement)

References 40 publications

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“…За даними ВООЗ, питома вага лікарських засобів рослинного походження у терапії найближчі 10 років може сягнути 60% [1,40]. Фітопрепарати поєднують у собі м'якість терапевтичної дії, можливість тривалого вживання, безпеку, застосування як для профілактики, так і лікування з ефективністю за різної патології від 40 до 87% [22,38].…”

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Phytotherapy in the management of women of reproductive age with dyshormonal gynecological pathology and mastalgia

Pyrohova,

Shurpyak,

Prokopchuk

2024

RHW

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Almost 70% of women suffer from breast pain during their life. Mastalgia reduces the quality of life of women, increases their fear of breast cancer and causes deterioration of the psycho-emotional state of women. Different forms of mastalgia require different medical tactics. To date, there are no generally accepted schemes for the treatment of cyclic mastalgia both in benign dysplasia of the mammary glands and in combined dyshormonal gynecological diseases.The objective: to study the effect of combined herbal remedies on the severity of cyclic mastalgia (primary outcome), menstrual function and side effects (secondary outcomes) in women of reproductive age with dyshormonal combined gynecological pathology.Materials and methods. 72 women from 25 to 39 years old with mastalgia participated in the study, they were divided into groups depending on the prescribed therapy and combined dyshormonal pathology (benign mammary dysplasia (BMD), genital endometriosis). The examination included an anthropometric study, ultrasonographic examination of the pelvic organs, mammary glands, determination of the levels of LH, FSH, TSH, prolactin and ovarian steroid hormones.Results. In 95.8% of the women of the studied cohort, the prolactin level ranged from 28.3 ng/ml to 37.6 ng/ml (on average – 33.7±5.4 ng/ml). Hormonal imbalance in patients with both combined dyshormonal pathology and monotopic cyclic mastalgia was characterized by the absence of pronounced hyperestrogenia in the I phase of the menstrual cycle (MC), relative hyperestrogenia in the II phase of the MC with an increase in the E2/P ratio from 5.1±0.2 to 13.4±0.3 compared to healthy women. 26.4% of patients came to the examination when the pain according to VAS was an average of 6.2±1.5 points, 73.6% of women suffered from mastalgia from 1 to 5 years and sought medical help due to the intensity of the pain syndrome according to VAS 9.2±0.7 points.Conclusions. The results of research proved the effectiveness and safety of the use of combined herbal preparations for the treatment of mastalgia. The use of the first combined herbal preparation was effective in 95% in eliminating and reducing the severity of cyclic mastalgia (primary result), the second herbal preparation – in 100% of cases in women of reproductive age with dyshormonal pathology of reproductive organs and BMD.The high efficiency of the use of the second phytocomplex for the treatment of mastalgia in patients with BMD and genital endometriosis without the additional use of hormonal drugs can be explained by the effect of the drug on the normalization of the prolactin level and the E2/P ratio.

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Phytotherapy in the management of women of reproductive age with dyshormonal gynecological pathology and mastalgia

Pyrohova,

Shurpyak,

Prokopchuk

2024

RHW

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Mastodynia: Current data on the causes, course, diagnosis, and treatment approaches. A review

Leschenko

2023

Gynecology

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Mastodynia is a common clinical symptom in general medical and gynecological practice. The objectives of this literature review are to analyze scientific information on the epidemiology of mastodynia/mastalgia, the impact on quality of life, inconsistencies in the etiology determination, to formulate a diagnostic concept, classification, and treatment, and to assess the therapeutic effects of Vitex Agnus-Castus. Scientific publications over the past 30 years were searched in the main research databases, CochraneLibrary, PubMed, Science Direct, Google Scholar, and ELibrary, using the terms "mastalgia," "mastodynia," "Vitex Agnus-Castus," "chest pain," "chest pain, breast pain." The pathophysiology of mastodynia is multifaceted, with various etiology factors and independent ways of pain occurrence. Most studies have emphasized the importance of correctly classifying breast pain for accurate diagnosis and effective therapy to reduce the frequency and severity of pain episodes and improve quality of life while minimizing side effects. Vitex Agnus-Castus is safe and effective in the treatment of mastodynia.

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The effect of the herbal medicine on severity of cyclic mastalgia: a systematic review and meta-analysis

Cited by 2 publications

References 40 publications

Phytotherapy in the management of women of reproductive age with dyshormonal gynecological pathology and mastalgia

Phytotherapy in the management of women of reproductive age with dyshormonal gynecological pathology and mastalgia

Mastodynia: Current data on the causes, course, diagnosis, and treatment approaches. A review

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