The effect of the homeopathic remedies Arnica montana and Bellis perennis on mild postpartum bleeding—A randomized, double-blind, placebo-controlled study—Preliminary results

Oberbaum, Menachem; Galoyan, Narine; Lerner‐Geva, Liat; Singer, Shepherd Roee; Grisaru, Sorina Granovsky; Shashar, David; Samueloff, Arnon

doi:10.1016/j.ctim.2005.03.006

Cited by 53 publications

(28 citation statements)

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“…Arnica (tablet and cream) was the remedy most often used at any time in pregnancy by this pregnancy sample. It is a popular first aid remedy for soft tissue bruising and trauma; its antihaemorrhagic effects have been researched in pregnancy for reducing postpartum blood loss [36] and it is recommended as a remedy following childbirth to reduce bruising, swelling and pain. [35] Aromatherapy, the fourth most used CAM within this study, is generally used for relaxation, stress and well-being.…”

Section: Discussionmentioning

confidence: 99%

The use of Complementary and Alternative Medicine in pregnancy: Data from the Avon Longitudinal Study of Parents and Children (ALSPAC)

Bishop

Northstone

Green

et al. 2011

Complementary Therapies in Medicine

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word count: 297 Main text word count: 2999Page 2 of 16 ObjectivesTo report the frequency of Complementary and Alternative Medicine (CAM) use by a population of pregnant women in the UK. DesignFour postal self-completion questionnaires completed at 8, 12, 18 and 32 weeks' gestation provided the source of CAMs used. Questions asked for written descriptions about the use of any treatments, pills, medicines, ointments, homeopathic medicines, herbal medicines, supplements, drinks and herbal teas. SettingAn observational, population-based, cohort study of parents and children of 14541 pregnant women residing within the former county of Avon in south-west England. Data was available for 14115 women. ResultsOver a quarter (26.7%; n=3774) of women had used a CAM at least once in pregnancy, the use rising from 6% in the 1 st trimester to 12.4% in the 2 nd to 26.3% in the 3 rd . Herbal teas were the most commonly reported CAM at any time in pregnancy (17.7%; n=2499) followed by homeopathic medicine (14.4%; n=2038) and then herbal medicine (5.8%; n=813). The most commonly used herbal product was chamomile used by 14.6% of women, the most commonly used homeopathic product was Arnica used by 3.1% of women. Other CAMs (osteopathy, aromatherapy, acupuncture/acupressure, Chinese herbal medicine, chiropractic, cranial sacral therapy, hypnosis, non-specific massage and reflexology) accounted for less than 1% of users. ConclusionsCAM use in pregnancy, where a wide range of CAMs has been assessed, has not been widely reported. Studies that have been conducted report varying results to this study (26.7%) by between 13.3% and 87% of pregnant women. Survey results will be affected by a number of factors namely the inclusion/exclusion of vitamins and minerals, the timing of data collection, the country of source, the number of women surveyed, and the different selection criteria of either recruiting women to the study or of categorising and identifying a CAM treatment or product.

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Section: Discussionmentioning

confidence: 99%

The use of Complementary and Alternative Medicine in pregnancy: Data from the Avon Longitudinal Study of Parents and Children (ALSPAC)

Bishop

Northstone

Green

et al. 2011

Complementary Therapies in Medicine

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“…Nine trials (22%) were rated as B (48,50,53,59,64,67,69,73,75), demonstrating average quality and medium risk of bias. A total of 22 trials (54%) reported both sample size calculations and intention to treat analyses.…”

Section: Methodological Quality Of the Rctsmentioning

confidence: 99%

“…Adverse effects were descriptively reported in five trials (49,51,60,78,79). Four trials used the term adverse drug reactions (66)(67)(68)75), two trials applied side effects (63,69), and one trial used unexpected effects (58).…”

Section: Methodological Quality Of the Rctsmentioning

confidence: 99%

Adverse effects of homeopathy, what do we know? A systematic review and meta-analysis of randomized controlled trials

Kristoffersen

Alræk

Liu

2016

Complementary Therapies in Medicine

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Highlights:• This review address the naive assumption that because of the generally diluted doses used homeopathy must be safe• This review touches the neglected issue of the distinction between homeopathic aggravation, adverse reactions and adverse effects• We found a similar risk for homeopathic treatment compared to controls such as placebo and conventional medicine. Words: 5,187 Abstract ObjectivesHomeopathy is a popular treatment modality among patient, however there is sparse research about adverse effects of homeopathy. A concept unique for homeopathy, is homeopathic aggravation that is understood as a transient worsening of the patients' symptoms before an 2 expected improvement occurs. From a risk perspective it is vital that a distinction between homeopathic aggravations and adverse effects is established. There is a lack of systematic information on how frequent adverse effects and homeopathic aggravations are reported in studies. Therefore, a systematic review and meta-analysis were performed. Design and settingSixteen electronic databases were searched for Randomized Controlled Trials (RCTs). The searches were limited from the year 1995 to January 2011. Forty-one RCTs, with a total of 6.055 participants were included. A subtotal of 39 studies was included in the additional metaanalysis. ResultsA total of 28 trials (68%) reported adverse effects and five trials (12%) reported homeopathic aggravations. The meta-analysis (including six subgroup comparisons) demonstrated that no significant difference was found between homeopathy and control with OR 0.99, 95% CI 0.86 to 1.14, I 2 = 54%. More than two third of the adverse effects were classified as grade 1 (68%) and two third were classified as grade 2 (25%) and grade 3 (6%) according to the Common Terminology Criteria for Adverse Effects. Homeopathic aggravation was classified as grade 1 (98%) and grade 3 (2%), suggesting that homeopathic aggravations were reported to be less severe than adverse effects. The methodological quality according to a method recommended in the Cochrane handbook for RCTs, was high. ConclusionAdverse effects including the concept of homeopathic aggravations are commonly reported in trials. The meta-analysis demonstrated that the proportion of patients experiencing adverse effects to be similar for patients randomized to homeopathic treatment compared to patients randomized to placebo and conventional medicine.

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“…Antibacterial (Avato et al, 1997;Kavalcioglu et al, 2010), antifungal (Desevedavy et al, 1989;Avato et al, 1997;Kavalcioglu et al, 2010), antihyperlipidemic (Morikawa et al, 2010a), antioxidant (Kavalcioglu et al, 2010), postpartum antihemorrhagic (Oberbaum et al, 2005), pancreatic lipase inhibitor (Morikawa et al, 2010b) and cytotoxic activities against HL-60 human promyelocytic leukemia cells (Li et al, 2005) of B. perennis have also been investigated.…”

Section: Pharmaceutical Biologymentioning

confidence: 99%

The evaluation of topical administration ofBellis perennisfraction on circular excision wound healing in Wistar albino rats

Karakaş¹,

Karakaş²,

Boran

et al. 2012

Pharmaceutical Biology

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The effect of the homeopathic remedies Arnica montana and Bellis perennis on mild postpartum bleeding—A randomized, double-blind, placebo-controlled study—Preliminary results

Cited by 53 publications

References 2 publications

The use of Complementary and Alternative Medicine in pregnancy: Data from the Avon Longitudinal Study of Parents and Children (ALSPAC)

The use of Complementary and Alternative Medicine in pregnancy: Data from the Avon Longitudinal Study of Parents and Children (ALSPAC)

Adverse effects of homeopathy, what do we know? A systematic review and meta-analysis of randomized controlled trials

The evaluation of topical administration ofBellis perennisfraction on circular excision wound healing in Wistar albino rats

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