The effect of the neurolathyrogenic substance β,β′-iminodipropionitrile (IDPN) on some biological parameters in rats and mice

Schneider, Gerold; Oepen, Heinrich; Klapproth, Adolf

doi:10.1016/0306-3623(81)90108-7

Cited by 29 publications

(5 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…46 Since this study was conducted in adult rats, the increase in organ weights in 24 hours or 5 days cannot be linked to body growth but is indicative of a short-term edema after IDPN treatment that gradually recovered with time. Schneider et al 47 have shown that different organs (brain, heart, liver, spleen) weight to body weight ratios are not influenced by IDPN treatment.…”

Section: Discussionmentioning

confidence: 99%

Time-Course Evaluation of Iminodipropionitrile-Induced Liver and Kidney Toxicities in Rats: A Biochemical, Molecular and Histopathological Study

et al. 2019

View full text Add to dashboard Cite

Iminodipropionitrile (IDPN) is known to produce axonopathy and vestibular hair cell degeneration. Recent histopathological studies have shown IDPN-induced liver and kidney toxicities in rodents; however, the associated mechanisms are not clearly understood. We investigated the role of proinflammatory cytokines in IDPN-induced liver and kidney toxicities in rats. Rats were treated with saline (control) and IDPN (100 mg/kg, intraperitoneally) daily for 1, 5, and 10 days, respectively. Animals were killed 24 hours after the last dose and liver and kidneys were collected for histopathology and interleukin-1β (IL-1β), IL-6, and tumor necrosis factor-α messenger RNA expression analysis. Serum aspartate aminotransferase and alanine aminotransferase activities were significantly increased after 10 doses of IDPN. The level of serum creatinine was initially increased after the first dose of IDPN but subsided on days 5 and 10. Blood urea nitrogen levels were significantly increased on days 5 and 10 following IDPN exposure. Histopathology showed dose-dependent hepatotoxicity in IDPN-treated rats. Iminodipropionitrile-induced expression of proinflammatory cytokines peaked after day 1 in liver and after day 5 in kidneys. In conclusion, repeated exposure of IDPN for 10 days produced significant structural and functional damages in rat liver whereas kidneys showed gradual recovery with time. These findings point toward the role of inflammatory mediators in IDPN-induced toxicity in rats.

show abstract

Section: Discussionmentioning

confidence: 99%

Time-Course Evaluation of Iminodipropionitrile-Induced Liver and Kidney Toxicities in Rats: A Biochemical, Molecular and Histopathological Study

et al. 2019

View full text Add to dashboard Cite

show abstract

“…When tested in a repeated acquisition paradigm in the RAM, IDPN-treated rats showed performance deficits that included a decreased rate of within session reduction in errors. The effects of IDPN on body weight, spontaneous behavior, and swimming ability have been known for a number of years (7,29,33). The mechanisms by which IDPN reduces body weight include reduced food and water intake (29).…”

Section: Discussionmentioning

confidence: 99%

“…The effects of IDPN on body weight, spontaneous behavior, and swimming ability have been known for a number of years (7,29,33). The mechanisms by which IDPN reduces body weight include reduced food and water intake (29). The alterations in both spontaneous behavior and swimming have been recently attributed to the vestibular toxicity of IDPN (20).…”

Section: Discussionmentioning

confidence: 99%

Effects of 3,3′-iminodipropionitrile on acquisition and performance of spatial tasks in rats

Llorens

Crofton

Peele

1994

Neurotoxicology and Teratology

View full text Add to dashboard Cite

3,3'-Iminodipropionitrile (IDPN) has been reported to disrupt learning and memory in rats (24). The present work addressed the effects of IDPN on tasks requiring the use of spatial information. Separate groups of male rats were dosed with IDPN (IP, in 1 ml/kg saline) for 3 consecutive days and tested in the following procedures: (a) step-through passive avoidance conditioning (0, 100, 150, and 200 mg/kg/day); (b) Morris water maze (MWM) acquisition and retention (0, 125, 150, 175, and 200 mg/kg/day); (c) radial arm maze (RAM) acquisition (0, 100, 200, and 400 mg/kg/day); (d) RAM steady-state performance (0, 200, and 400 mg/kg/day); (e) repeated acquisition in the RAM (0, and 200 mg/kg/day). The vestibular toxicity of IDPN resulted in alterations in spontaneous behavior or swimming deficits in 5 of 8 rats treated with 175 mg/kg/day and in all the animals dosed with 200 or 400 mg/kg/day. IDPN increased step-through PA latencies at 200 mg/kg/day but not at lower doses. In the MWM, no performance deficits were observed at the dose levels preserving the swimming ability of the animals. In both the acquisition and the steady-state RAM tasks, IDPN (400 mg/kg/day) induced an increase in both choice errors and perseverative errors. In the RAM repeated acquisition paradigm, IDPN (200 mg/kg/day) induced performance deficits that included a decreased rate of within-session reduction in errors. The present data show that IDPN disrupts performance of tasks requiring spatial learning and memory and indicate that these deficits can be in part caused by an acquisition deficit.

show abstract

“…Chronic exposure to neurotoxin h,hV-iminodipropionitrile (IDPN) is known to induce permanent motor behavioral abnormalities in rats, characterized by persistent spasmodic dyskinetic head movements, circling, and increased startle responses [1,2]. This behavior syndrome is also termed as ''ECC syndrome'' (excitation, circling and choreoathetoid, neck movements) [3], the animal model for Gilles de la Tourette syndrome in humans.…”

Section: Introductionmentioning

confidence: 99%

Inhibitory effect of free radical scavenger, MCI-186, in the increase of hydroxyl radical induced by iminodipropionitrile in rats

Nomoto

2004

Journal of the Neurological Sciences

View full text Add to dashboard Cite

The effect of the neurolathyrogenic substance β,β′-iminodipropionitrile (IDPN) on some biological parameters in rats and mice

Cited by 29 publications

References 6 publications

Time-Course Evaluation of Iminodipropionitrile-Induced Liver and Kidney Toxicities in Rats: A Biochemical, Molecular and Histopathological Study

Time-Course Evaluation of Iminodipropionitrile-Induced Liver and Kidney Toxicities in Rats: A Biochemical, Molecular and Histopathological Study

Effects of 3,3′-iminodipropionitrile on acquisition and performance of spatial tasks in rats

Inhibitory effect of free radical scavenger, MCI-186, in the increase of hydroxyl radical induced by iminodipropionitrile in rats

Contact Info

Product

Resources

About