The effect of the oral administration of polymeric nanoparticles on the efficacy and toxicity of tamoxifen

Jain, Amit; Swarnakar, Nitin K.; Godugu, Chandraiah; Singh, Raman P.; Jain, Sanyog

doi:10.1016/j.biomaterials.2010.09.037

Cited by 213 publications

(135 citation statements)

References 39 publications

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“…The resultant w/o/w emulsion was stirred overnight to evaporate the organic phase. The composite nanoparticles were collected by centrifugation at 30,000× g for 30 minutes (3K30; Sigma Centrifuge, UK) and washed twice with distilled water before re-suspending in 5% w/v aqueous trehalose solution and freeze-dried (Advantage, VirTis, Gardiner, NY, USA) using a protocol modified from Jain et al 29 To investigate the effect of surface modification on transfection efficiency, Tf-appended composite nanoparticles were also prepared. Transferrin was adsorbed on the surface of nanoparticles using modifications of reported methods 30,31 suspending the nanoparticles in 10 mM 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid buffer, pH 7.4, with 150 mM NaCl containing transferrin.…”

Section: Formulation Of Composite Nanoparticles By Double Emulsion Somentioning

confidence: 99%

Development of polymeric–cationic peptide composite nanoparticles, a nanoparticle-in-nanoparticle system for controlled gene delivery

Jain¹,

Massey²,

Yusuf³

et al. 2015

IJN

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We report the formulation of novel composite nanoparticles that combine the high transfection efficiency of cationic peptide-DNA nanoparticles with the biocompatibility and prolonged delivery of polylactic acid–polyethylene glycol (PLA-PEG). The cationic cell-penetrating peptide RALA was used to condense DNA into nanoparticles that were encapsulated within a range of PLA-PEG copolymers. The composite nanoparticles produced exhibited excellent physicochemical properties including size <200 nm and encapsulation efficiency >80%. Images of the composite nanoparticles obtained with a new transmission electron microscopy staining method revealed the peptide-DNA nanoparticles within the PLA-PEG matrix. Varying the copolymers modulated the DNA release rate >6 weeks in vitro. The best formulation was selected and was able to transfect cells while maintaining viability. The effect of transferrin-appended composite nanoparticles was also studied. Thus, we have demonstrated the manufacture of composite nanoparticles for the controlled delivery of DNA.

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Section: Formulation Of Composite Nanoparticles By Double Emulsion Somentioning

confidence: 99%

Development of polymeric–cationic peptide composite nanoparticles, a nanoparticle-in-nanoparticle system for controlled gene delivery

Jain¹,

Massey²,

Yusuf³

et al. 2015

IJN

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“…The toxicity of NP drug delivery systems has been a prominent concern over the past 10 years (Nahar et al, 2008;Jain et al, 2011). Related studies have shown that NPs enhance therapeutic effects but can also increase toxicity.…”

Section: Mtt Assaymentioning

confidence: 99%

Preparation and in vitro evaluation of thienorphine-loaded PLGA nanoparticles

Yang¹,

Xie

Mei³

2014

Drug Delivery

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Poly (D,L-lactic-co-glycolide) nanoparticles (PLGA-NPs) have attracted considerable interest as new delivery vehicles for small molecules, with the potential to overcome issue such as poor drug solubility and cell permeability. However, their negative surface charge decreases bioavailability under oral administration. Recently, cationically modified PLGA-NPs has been introduced as novel carriers for oral delivery. In this study, our aim was to introduce and evaluate the physiochemical characteristics and bioadhesion of positively charged chitosancoated PLGA-NPs (CS-PLGA-NPs), using thienorphine as a model drug. These results indicated that both CS-PLGA-NPs and PLGA-NPs had a narrow size distribution, averaging less than 130 nm. CS-PLGA-NPs was positively charged (+42.1 ± 0.4 mV), exhibiting the cationic nature of chitosan, whereas PLGA-NPs showed a negative surface charge (À2.01 ± 0.3 mV). CS-PLGA-NPs exhibited stronger bioadhesive potency than PLGA-NPs. Furthermore, the transport of thienorphine-CS-PLGA-NPs by Caco-2 cells was higher than thienorphine-PLGA-NPs or thienorphine solution. CS-PLGA-NPs were also found to significantly enhance cellular uptake compared with PLGA-NPs on Caco-2 cells. An evaluation of cytotoxicity showed no increase in toxicity in either kind of nanoparticles during the formulation process. The study proves that CS-PLGA-NPs can be used as a vector in oral drug delivery systems for thienorphine due to its positive surface charge and bioadhesive properties.

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“…PLGA nanoparticles were first prepared via a W 1 /O/W 2 synthetic process. 29 Spherical morphology and smooth surface of PLGA nanoparticles were observed by SEM and TEM images. The SEM image in Figure 1A confirmed that the bare PLGA nanoparticles were uniform.…”

Section: Resultsmentioning

confidence: 97%

Mn<sup>2+</sup>-coordinated PDA@DOX/PLGA nanoparticles as a smart theranostic agent for synergistic chemo-photothermal tumor therapy

Yang

et al. 2017

IJN

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Nanoparticle drug delivery carriers, which can implement high performances of multi-functions, are of great interest, especially for improving cancer therapy. Herein, we reported a new approach to construct Mn 2+ -coordinated doxorubicin (DOX)-loaded poly(lactic- co -glycolic acid) (PLGA) nanoparticles as a platform for synergistic chemo-photothermal tumor therapy. DOX-loaded PLGA (DOX/PLGA) nanoparticles were first synthesized through a double emulsion-solvent evaporation method, and then modified with polydopamine (PDA) through self-polymerization of dopamine, leading to the formation of PDA@DOX/PLGA nanoparticles. Mn 2+ ions were then coordinated on the surfaces of PDA@DOX/PLGA to obtain Mn 2+ -PDA@DOX/PLGA nanoparticles. In our system, Mn 2+ -PDA@DOX/PLGA nanoparticles could destroy tumors in a mouse model directly, by thermal energy deposition, and could also simulate the chemotherapy by thermal-responsive delivery of DOX to enhance tumor therapy. Furthermore, the coordination of Mn 2+ could afford the high magnetic resonance (MR) imaging capability with sensitivity to temperature and pH. The results demonstrated that Mn 2+ -PDA@ DOX/PLGA nanoparticles had a great potential as a smart theranostic agent due to their imaging and tumor-growth-inhibition properties.

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The effect of the oral administration of polymeric nanoparticles on the efficacy and toxicity of tamoxifen

Cited by 213 publications

References 39 publications

Development of polymeric–cationic peptide composite nanoparticles, a nanoparticle-in-nanoparticle system for controlled gene delivery

Development of polymeric–cationic peptide composite nanoparticles, a nanoparticle-in-nanoparticle system for controlled gene delivery

Preparation and in vitro evaluation of thienorphine-loaded PLGA nanoparticles

Mn<sup>2+</sup>-coordinated PDA@DOX/PLGA nanoparticles as a smart theranostic agent for synergistic chemo-photothermal tumor therapy

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The effect of the oral administration of polymeric nanoparticles on the efficacy and toxicity of tamoxifen

Cited by 213 publications

References 39 publications

Development of polymeric&ndash;cationic peptide composite nanoparticles, a nanoparticle-in-nanoparticle system for controlled gene delivery

Development of polymeric&ndash;cationic peptide composite nanoparticles, a nanoparticle-in-nanoparticle system for controlled gene delivery

Preparation and in vitro evaluation of thienorphine-loaded PLGA nanoparticles

Mn<sup>2+</sup>-coordinated PDA@DOX/PLGA nanoparticles as a smart theranostic agent for synergistic chemo-photothermal tumor therapy

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Development of polymeric–cationic peptide composite nanoparticles, a nanoparticle-in-nanoparticle system for controlled gene delivery

Development of polymeric–cationic peptide composite nanoparticles, a nanoparticle-in-nanoparticle system for controlled gene delivery