The Effect of the Phytoestrogen Genistein on Myocardial Protection, Preconditioning and Oxidative Stress

Sbarouni, Eftihia; Iliodromitis, Efstathios K.; Ζώγα, Αναστασία; Vlachou, G.; Andreadou, Ioanna; Kremastinos, Dimitrios Th.

doi:10.1007/s10557-006-8971-6

Cited by 17 publications

(17 citation statements)

References 42 publications

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“…Estrogen impact on cardioprotective effects and ovariectomized females is more susceptible to cardioprotective maneuvers [101, 367]. For this reason, male rabbits are usually taken for initial studies.…”

Section: Small Animal Hearts In Situmentioning

confidence: 99%

Practical guidelines for rigor and reproducibility in preclinical and clinical studies on cardioprotection

et al. 2018

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Section: Small Animal Hearts In Situmentioning

confidence: 99%

Practical guidelines for rigor and reproducibility in preclinical and clinical studies on cardioprotection

et al. 2018

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“…Moreover, the use of lipid-lowering therapy is strongly influenced by reimbursement criteria revision, and the female gender was identified as a patient-related predictor of low adherence [8,9,10]. The advantages of estrogen supplementation are preserved in early menopause, failing to maintain cardiovascular protection, thus further therapeutic options continue to be studied [11,12,13]. Genistein aglycone (hereinafter referred to as genistein) is a soy isoflavone, which has progressively gained clinical consideration for the management of postmenopausal symptoms.…”

Section: Introductionmentioning

confidence: 99%

“…Its molecular structure resembles that of 17β–estradiol and binds the same estrogen-receptors in a dose-dependent manner. Regular supplementation in combination with a Mediterranean-style diet, regular exercise, and medical therapy improve CV risk, endothelial function, and vascular reactivity in MetS women, although, to date, very little data are available concerning the effect of genistein on heart function [12,14,15,16,17,18]. …”

Section: Introductionmentioning

confidence: 99%

Genistein Supplementation and Cardiac Function in Postmenopausal Women with Metabolic Syndrome: Results from a Pilot Strain-Echo Study

et al. 2017

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Genistein, a soy-derived isoflavone, may improve cardiovascular risk profile in postmenopausal women with metabolic syndrome (MetS), but few literature data on its cardiac effects in humans are available. The aim of this sub-study of a randomized double-blind case-control study was to analyze the effect on cardiac function of one-year genistein dietary supplementation in 22 post-menopausal patients with MetS. Participants received 54 mg/day of genistein (n = 11) or placebo (n = 11) in combination with a Mediterranean-style diet and regular exercise. Left ventricular (LV) systolic function was assessed as the primary endpoint, according to conventional and strain-echocardiography measurements. Also, left atrial (LA) morphofunctional indices were investigated at baseline and at the final visit. Results were expressed as median with interquartile range (IQ). A significant improvement of LV ejection fraction (20.3 (IQ 12.5) vs. −1.67 (IQ 24.8); p = 0.040)), and LA area fractional change (11.1 (IQ 22.6) vs. 2.8 (9.5); p = 0.034)) were observed in genistein patients compared to the controls, following 12 months of treatment. In addition, body surface area indexed LA systolic volume and peak LA longitudinal strain significantly changed from basal to the end of the study in genistein-treated patients. One-year supplementation with 54 mg/day of pure genistein improved both LV ejection fraction and LA remodeling and function in postmenopausal women with MetS.

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“…We also showed that acute administration of vitamin E reduced infarct size and maintained the beneficial effect of ischemic preconditioning without altering plasma malondialdehyde during ischemia and reperfusion [146]. Moreover, the phytoestrogen genistein did not abolish the protection induced by preconditioning in both ovariectomized and non-ovariectomized rabbits and did not inhibit lipid peroxidation [147]. An in vivo study showed that the administration of N-2-mercapropropionyl glycine 45 min before the sustained ischemia had no effect on infarct size, prevented the protection from one cycle of ischemic preconditioning, but did not prevent the protection from four cycles of ischemic preconditioning in situ in anesthetized rabbits [148].…”

Section: Antioxidants In Preconditioning and Postconditioningmentioning

confidence: 73%

To prevent, protect and save the ischemic heart: antioxidants revisited

Andreadou

Iliodromitis

Farmakis

et al. 2009

Expert Opinion on Therapeutic Targets

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Reactive oxygen species (ROS) and reactive nitrogen species (RNS) formation increases in the post-ischemic myocardium and represents a mechanism of post ischemic injury. ROS, which are formed during reperfusion, trigger lipid peroxidation, oxidize proteins and cause DNA strand breaks, all interfering with and potentially damaging normal cellular function. Oxidative stress is associated with poor recovery of left ventricular function after a sustained period of ischemia and, according to several studies, it contributes significantly to the acceleration of necrosis and thus extension of infarction, apoptosis, arrhythmiogenesis and endothelial dysfunction. Accordingly, targeting the generation of ROS with various antioxidants has been shown to improve left ventricular function after the restoration of flow. Apart from mechanical or pharmacological interventions that open the occluded artery, the heart has endogenous mechanisms of protection, called ischemic pre-conditioning and ischemic post-conditioning. Opening of the mitochondrial ATP-sensitive potassium channels and subsequent generation of ROS is considered to be a pivotal step in the mechanisms of pre- and post-conditioning. Notably, ROS play an ambiguous role in the protection of myocardium and can be both effective and harmful. Thus, the role of antioxidants in the attenuation of the effects of pre-and post-conditioning in vivo remains controversial.

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The Effect of the Phytoestrogen Genistein on Myocardial Protection, Preconditioning and Oxidative Stress

Cited by 17 publications

References 42 publications

Practical guidelines for rigor and reproducibility in preclinical and clinical studies on cardioprotection

Practical guidelines for rigor and reproducibility in preclinical and clinical studies on cardioprotection

Genistein Supplementation and Cardiac Function in Postmenopausal Women with Metabolic Syndrome: Results from a Pilot Strain-Echo Study

To prevent, protect and save the ischemic heart: antioxidants revisited

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