The effect of the placental DROSHA rs10719 and rs6877842 polymorphisms on PE susceptibility and mRNA expression

Rezaei, Mahnaz; Mohammadpour‐Gharehbagh, Abbas; Narooei‐Nejad, Mehrnaz; Teimoori, Batool; Mokhtari, Mojgan; Mehrabani, Mehrnaz; Yaghmaei, Minoo; Najafi, Darya; Salimi, Saeedeh

doi:10.1038/s41371-018-0156-9

Cited by 7 publications

(8 citation statements)

References 28 publications

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“…Indeed, the combination of CC/GG genotypes of DROSHA rs10719 and rs6877842 polymorphisms was associated with a higher risk of PE. The expression of DROSHA gene was downregulated in the placenta of PE women and those with rs10719CC genotype …”

Section: Discussionmentioning

confidence: 93%

“…Considering the role of them in biogenesis of miRNAs, they are known as key molecules in various processes of normal pregnancy . Several other recent studies have evaluated the levels of miRNA machinery proteins in various pregnancy complications . Since a genetic etiology of RSA has been detected, numerous studies have examined the effects of genetic polymorphisms of miRNAs and miRNA machinery biogenesis genes on the pathogenesis of RSA …”

Section: Discussionmentioning

confidence: 99%

“…13 Several other recent studies have evaluated the levels of miRNA machinery proteins in various pregnancy complications. 15 Since a genetic etiology of RSA has been detected, numerous studies have examined the effects of genetic polymorphisms of miRNAs and miRNA machinery biogenesis genes on the pathogenesis of RSA. 10,20 In the current study, we evaluated the effects of DICER1 rs3742330 and DROSHA rs6877842 polymorphisms on RSA and found a negative association between DICER1 rs3742330 polymorphism and RSA risk in dominant and allelic models.…”

Section: Discussionmentioning

confidence: 99%

“…Considering the role of genetic variants in pathogenesis of multifactorial diseases, numerous studies have evaluated the effects of miRNA and miRNA biosynthesis machinery polymorphisms on their pathogenesis . DROSHA and DICER1 genes are located on chromosomes 5 and 14, respectively .…”

Section: Introductionmentioning

confidence: 99%

“…13 Considering the role of genetic variants in pathogenesis of multifactorial diseases, numerous studies have evaluated the effects of miRNA and miRNA biosynthesis machinery polymorphisms on their pathogenesis. [14][15][16] DROSHA and DICER1 genes are located on chromosomes 5 and 14, respectively. 17,18 There are several single nucleotide polymorphisms (SNPs) in DROSHA and DICER1 genes, and their effects on various diseases have been investigated.…”

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confidence: 99%

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The effects of DICER1 and DROSHA polymorphisms on susceptibility to recurrent spontaneous abortion

Ghasemi

Rezaei

Yazdi

et al. 2019

Clinical Laboratory Analysis

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Background Recurrent spontaneous abortion (RSA) is a serious problem in pregnancy. The exact etiology of RSA is unknown in more than 50% of all the patients. However, genetic variations are known as susceptibility factors for idiopathic RSA. Considering the role of miRNA biosynthesis machinery in the miRNA production and effect of miRNAs on various diseases, this study aimed to evaluate the effects of DICER1 rs3742330 and DROSHA rs6877842 polymorphisms on RSA risk. Methods In this case‐control study, 150 RSA patients and 195 age‐matched healthy female controls were recruited. Both polymorphisms were genotyped using PCR‐RFLP method. Results The frequency of DICER1 rs3742330AG genotype was higher in the control group (P = .022). There was a statistically significant association between rs3742330 polymorphism and a reduced RSA risk in dominant and allelic models (P = .013 and P = .007, respectively). No statistically significant association was found between DROSHA rs6877842 variant and RSA risk. The combination of AG and GC genotypes and G‐G alleles of DICER1 rs3742330 and DROSHA rs6877842 polymorphisms led to a decreased RSA risk. However, the synergic effect of rs3742330A and rs6877842G alleles (A‐G) and AA‐GG genotypes was associated with an increased RSA risk. Conclusion the DICER1 rs3742330AG genotype and combination of AG and GC genotypes and G‐G alleles of DICER1 rs3742330 and DROSHA rs6877842 polymorphisms were associated with a reduced RSA risk.

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Section: Discussionmentioning

confidence: 93%

Section: Discussionmentioning

confidence: 99%