The effect of the stimulus for infection on hormones in Haemonchus contortus

Rogers, W. P.; Head, Richard

doi:10.1016/0010-4035(72)90035-3

Cited by 26 publications

(4 citation statements)

References 14 publications

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“…The presence of aminergic neurosecretory cells in nematodes has been suggested by ultrastructural studies on P. decipiens and Haemonchus contorrus (Davey, 1976). Other studies have indicated a metabolic role for noradrenaline in H. contortus larvae (Rogers & Head, 1972) and a reproductive one for 5-HT in A . tetraptera (Anya, 1973~).…”

Section: Discussionmentioning

confidence: 92%

Catecholaminergic structures in the nervous system of three nematode species, with observations on related enzymes

Wright¹,

Awan²

1978

Journal of Zoology

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The formaldehyde fluorescence technique has been used to demonstrate amine‐specific fluorescence in the nervous system of three nematode species, Prionchulus punclatus Cobb, Panagrellus redivivus Goodey, and Aphelenchus avenae Bastian. Examination of some of the physical and chemical properties of this fluorescence has shown it to be due principally to the primary catecholamine dopamine. Dopamine and dopa decarboxylase were also detected biochemically in A. avenae. Dopamine has now been proposed as a putative neurotransmitter in a number of nematode species and the role of this and other biogenic amines in nematodes is discussed. Of the two principal enzymes involved in the metabolism of monoamines, catechol‐O‐methyltransferase was detected in both A. avenae and P. redivivus but monoamine oxidase could not be detected in these or other nematode species.

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Section: Discussionmentioning

confidence: 92%

Catecholaminergic structures in the nervous system of three nematode species, with observations on related enzymes

Wright¹,

Awan²

1978

Journal of Zoology

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“…While aminergic cells become depleted, peptidergic cells become more prominent, the former preceding the latter in time (Davey 1966;Goh 1975). Noradrenalin appears to be involved in the chain of events leading to exsheathment of ,the third-stage larva in Haemonchus contortus (Rogers and Head 1972;Davey et al 1982), and will cause ensheathed Phocanema to ecdyse (Goh 1975). Whether the amine acts directly on the excretory cell or acts indirectly via peptidergic cells is a problem which can be approached with the techniques outlined here.…”

Section: Discussionmentioning

confidence: 99%

Ecdysis in a parasitic nematode: direct evidence for an ecdysial factor from the head

Davey¹,

Goh²

1984

Can. J. Zool.

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Incubating intact Phocanema decipiens in 0.9% NaCl containing insect juvenile hormone 1 (JH) leads to an increase in water volume of the excretory cell as determined by exchange with 3H2O, while incubation in 0.9% NaCl without JH does not. Ligaturing the head end of the worm prevents this increase and injection of extracts of heads into worms stimulates an increase in water content. Application of extract of heads to excretory cells in vitro also leads to an increase in water content of the cells.

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“…Localization experiments using techniques such as formaldehyde-induced fluorescence, have shown catecholamines to be present in many nematode species (HORVITZ et al, 1982;MISHRA etal., 1984;LEE & Ko, 1991). Noradrenaline (NA) would appear to play a part in the ecdysis of certain nematodes; stimulation of the development of Haemonchus contortus leads to a large increase in their NA content (ROGERS & HEAD, 1972;SHISOV, 1980). DAVEY et al (1982) demonstrated that treatment of worms with exogenous NA initiated changes in the excretory cells which accompany the normal ecdysial process.…”

Section: Introductionmentioning

confidence: 99%

The effect of catecholamines and catecholamine antagonists on the third larval moult of Dirofilaria immitis in vitro

Warbrick

Ward

1992

J. Helminthol.

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Various catecholamines and catecholamine antagonists have been examined for their effects on the third larval moult of the parasitic nematode, Dirofilaria immitis, cultured in vitro. The non-selective α and β agonist, noradrenaline, and the β agonist, isoprenaline, had no effect on the timing of the third stage moult when used at a concentration of 10−5M. The α-adrenergic antagonist. phentolamine, resulted in worm mortality at 10−5M. At 10−7M, both phentolamine and the β-antagonist, propranolol caused a significant reduction in the numbers of larvae capable of completing the third stage moult. Idazoxan, an a2-antagonist, at 10−5M did not affect worm mortality but did completely prevent ecdysis. The potential of these compounds as possible filaricides is discussed.

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The effect of the stimulus for infection on hormones in Haemonchus contortus

Cited by 26 publications

References 14 publications

Catecholaminergic structures in the nervous system of three nematode species, with observations on related enzymes

Catecholaminergic structures in the nervous system of three nematode species, with observations on related enzymes

Ecdysis in a parasitic nematode: direct evidence for an ecdysial factor from the head

The effect of catecholamines and catecholamine antagonists on the third larval moult of Dirofilaria immitis in vitro

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